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Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle.
Open accessAbstract
A 26 amino acid synthetic peptide fragment of atrial natriuretic factor (ANF) relaxed isolated rabbit aortic segments in which the endothelium was either intact or functionally destroyed. The relaxations were temporally associated with increases in levels of cGMP with no change in the levels of cAMP. The ANF-induced increases in cGMP were also observed in aortic segments pretreated with calcium-free buffer or the cGMP phosphodiesterase inhibitor M&B 22,948. Qualitatively similar results were obtained for sodium nitroprusside. ANF selectively activated particulate guanylate cyclase, having no effect on the soluble form of the enzyme. Thus, the direct (endothelium-independent) vasodilator effect of ANF may be mediated via increased tissue levels of cGMP. ANF appears to increase vascular cGMP levels by activation of particulate guanylate cyclase.
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Citations
Cited by
A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor
Chinkers, M., Garbers, D. L., Chang, M.-S., Lowe, D. G., Chin, H., Goeddel, D. V., & Schulz, S. (1989) · Nature · doi:10.1038/338078a0 · Cited by 992
Cyclic guanosine monophosphate as a mediator of vasodilation.
Murad, F. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112536 · Cited by 799
Self-citationKim, M., Platt, M. J., Shibasaki, T., Quaggin, S. E., Backx, P. H., Seino, S., Simpson, J. A., & Drucker, D. J. (2013) · Nature Medicine · doi:10.1038/nm.3128 · Cited by 514
Effects of Cyclic GMP on Smooth Muscle Relaxation
Warner, T. D., Mitchell, J. A., Sheng, H., & Murad, F. (1994) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)60054-x · Cited by 117
Self-citationA Short History of cGMP, Guanylyl Cyclases, and cGMP-Dependent Protein Kinases
Kots, A. Y., Martin, E., Sharina, I. G., & Murad, F. (2009) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-540-68964-5_1 · Cited by 82
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Metadata
- Authors
- Winquist, R. J., Faison, E. P., Waldman, S. A., Schwartz, K., Murad, F., & Rapoport, R. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1984-12
- Volume
- 81
- Issue
- 23
- Pages
- 7661-7664
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2065265905
- Cited by
- 497
- References
- 0
- FWCI
- 63.97
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. https://app.cochat.ai/papers/10.1073/pnas.81.23.7661
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- Winquist, R. J., Faison, E. P., Waldman, S. A., Schwartz, K., Murad, F., & Rapoport, R. M. (1984). Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.81.23.7661
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
