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Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence.
Open accessAbstract
With regard to currently available class III agents, although their class III effect may reduce the likelihood of tachycardia initiation, their reverse use-dependent prolongation of action potential duration reduces their effectiveness during tachycardias and may even render them proarrhythmic, especially after long diastolic intervals. In contrast, agents that exhibit normal use-dependent prolongation of refractoriness hold great promise: While having relatively less effects on the normal heart beat, they could induce self-termination of a tachycardia. Prolongation of refractoriness can be achieved by lengthening of action potential duration and delaying recovery of excitability. Combination of these drug actions may yield important clinical applications.
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Cited by
Jurkiewicz, N. K., & Sanguinetti, M. C. (1993) · Circulation Research · doi:10.1161/01.res.72.1.75 · Cited by 513
Haverkamp*, W. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00119-x · Cited by 486
Evidence for Two Components of Delayed Rectifier K+Current in Human Ventricular Myocytes
Li, G.-R., Feng, J., Yue, L., Carrier, M., & Nattel, S. (1996) · Circulation Research · doi:10.1161/01.res.78.4.689 · Cited by 470
Recanatini, M., Poluzzi, E., Masetti, M., Cavalli, A., & De Ponti, F. (2005) · Medicinal Research Reviews · doi:10.1002/med.20019 · Cited by 285
Exaggerated QT prolongation after cardioversion of atrial fibrillation
Choy, A. M. J., Darbar, D., Dell’Orto, S., & Roden, D. M. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00226-0 · Cited by 89
Metadata
- Authors
- Hondeghem, L. M., & Snyders, D. J.
- Venue
- Circulation
- Published
- 1990-02
- Volume
- 81
- Issue
- 2
- Pages
- 686-690
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1967151871
- Cited by
- 603
- References
- 0
- FWCI
- 23.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence. https://app.cochat.ai/papers/10.1161/01.cir.81.2.686
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- Hondeghem, L. M., & Snyders, D. J. (1990). Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence. Circulation. https://doi.org/10.1161/01.cir.81.2.686
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
