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Cited by 150Fatty Acid Research and HealthCoronary Interventions and DiagnosticsAntiplatelet Therapy and Cardiovascular Diseases

Double-blind, randomized, controlled trial of fish oil supplements in prevention of recurrence of stenosis after coronary angioplasty.

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Bairati, I, Roy, L, Meyer, F·1992·Circulation
DOI 10.1161/01.cir.85.3.950
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Abstract

BACKGROUND: Previous studies suggest that recurrence of coronary stenosis after percutaneous transluminal coronary angioplasty (PTCA) might be prevented with dietary supplements rich in omega-3 fatty acids. The purpose of the present study was to evaluate this hypothesis. In addition, the relation between usual dietary consumption of omega-3 fatty acids and restenosis was assessed. METHODS AND RESULTS: A double-blind, randomized, controlled trial was conducted in which 205 patients undergoing a first PTCA received 15 capsules per day containing 1 g of either fish oil (2.7 g/day of eicosapentaenoic acid, 1.8 g/day of docosahexaenoic acid) or olive oil. The treatment was started 3 weeks before PTCA and continued for 6 months thereafter. Dietary intake was assessed by food frequency questionnaire. At 6 months after PTCA, patients underwent a control angiography. All angiographic lesions were measured by quantitative computer analysis. Four criteria were used to define restenosis. Restenosis occurred less often in the fish oil group (22.0-35.6% depending on the definition) than in the control group (40.0-53.3%). After controlling for other risk factors of restenosis, the association of fish oil supplementation with a lower frequency of restenosis was statistically significant (p = 0.03) for three of four definitions. After adjustment, a dietary intake of omega-3 fatty acids of more than 0.15 g/day was also associated with a lower frequency of restenosis (p less than or equal to 0.03). CONCLUSIONS: This trial documented the protective effect of fish oil supplements on the recurrence of coronary stenosis 6 months after PTCA. The study results suggest that a dietary intervention could be useful in preventing restenosis.

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  • In four trials, 4 g/day O3AEE produced an average 26% reduction in triglycerides, while a dietary supplement study of 3 g/day EPA+DHA produced a 35% reduction.

    “In 4 trials, 4 g/d O3AEE averaged a 26% reduction in triglycerides, whereas the reduction in a dietary supplement study of 3 g/d EPA+DHA was 35%.”

    From Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association (2019) · cites this paper as [44]

    The Baseline Characteristics section (page not supplied) reports a triglyceride decrease from 2.3 to 1.5 mmol/L at one month—approximately 35%—in the fish-oil group. But the Study Design section specifies 4.5 g/day of EPA+DHA, not 3 g/day, and this single trial does not report an average 26% reduction across four O3AEE trials. (LLM, conf=0.87)

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Authors
Bairati, I., Roy, L., & Meyer, F.
Affiliations
Université Laval (CA)
ORCID
Bairati, I
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1992-03
Volume
85
Issue
3
Pages
950-956
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.85.3.950
OpenAlex
W2058598807
Cited by
150
References
35
Citations by year
2026: 1 · 2025: 1 · 2021: 2 · 2019: 1 · 2016: 3 · 2014: 2 · 2013: 1 · 2012: 4
FWCI
21.37
Type
journal article
Language
en
Open access
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Agriculture
  • Fonds de Recherche du Québec - Santé
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
Keywords
fish oil supplementation, omega-3 fatty acids, restenosis, percutaneous transluminal coronary angioplasty, eicosapentaenoic acid, docosahexaenoic acid, olive oil, coronary artery disease
MeSH terms
Coronary Disease, Docosahexaenoic Acids, Double-Blind Method, Drug Combinations, Female, Fish Oils, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Recurrence, Risk Factors, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Angioplasty, Balloon, Coronary, Coronary Angiography

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