The DOI matches its Crossref record; 8 of the 9 references it cites were found in a registry or an index.
Relation between ventricular repolarization duration and cardiac cycle length during 24-hour Holter recordings. Findings in normal patients and patients with long QT syndrome.
Open accessAbstract
BACKGROUND: The interval from the R wave to the maximum amplitude of the T wave (RTm) contains the heart rate dependency of ventricular repolarization. METHODS AND RESULTS: A computer algorithm was developed to quantify the RTm and preceding RR intervals for each of more than 50,000 beats on 24-hour ambulatory electrocardiographic (Holter) recordings to evaluate the dynamic relation between repolarization duration and cycle length. The relation of RTm to the preceding RR interval (RTm/RR slope) was determined by the best-fit linear regression equation between these two parameters. Eleven normal subjects and 16 patients with long QT syndrome (LQTS) were investigated. Six of the normal subjects had Holter recordings obtained before and after beta-blocker therapy. beta-Blockers were associated with a significant (p = 0.005) reduction in the RTm/RR slope from 0.13 +/- 0.02 to 0.10 +/- 0.02. The mean value of the RTm/RR slope was significantly (p = 0.003) larger in the LQTS patients (0.21 +/- 0.08) than in normal subjects (0.14 +/- 0.03). CONCLUSIONS: These findings indicate that 1) quantification of the dynamic relation between ventricular repolarization and RR cycle length can be obtained on a large number of Holter-recorded heart beats; 2) beta-blockers reduce the RTm/RR slope in normal patients; and 3) LQTS patients have an exaggerated delay in repolarization at long RR cycle lengths.
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Cites
The long QT syndromes: A critical review, new clinical observations and a unifying hypothesis
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Electrocardiographic quantitation of ventricular repolarization.
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Self-citationSampling frequency of the electrocardiogram for spectral analysis of the heart rate variability
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Self-citationPermanent cardiac pacing in patients with the long QT syndrome
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Sorted by citations
Beat-to-Beat QT Interval Variability
Berger, R. D., Kasper, E. K., Baughman, K. L., Marbán, E., Calkins, H. G., & Tomaselli, G. F. (1997) · Circulation · doi:10.1161/01.cir.96.5.1557 · Cited by 613
Genetically Defined Therapy of Inherited Long-QT Syndrome
Compton, S. J., Lux, R. L., Ramsey, M. R., Strelich, K. R., Sanguinetti, M. C., Green, L. S., Keating, M. T., & Mason, J. W. (1996) · Circulation · doi:10.1161/01.cir.94.5.1018 · Cited by 313
Steinberg, J. S., Varma, N., Cygankiewicz, I., Aziz, P., Balsam, P., Baranchuk, A., Cantillon, D. J., Dilaveris, P., Dubner, S. J., El-Sherif, N., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.038 · Cited by 303
Self-citationInfluence of Pregnancy on the Risk for Cardiac Events in Patients With Hereditary Long QT Syndrome
Rashba, E. J., Zaręba, W., Moss, A. J., Hall, W. J., Robinson, J. L., Locati, E. H., Schwartz, P. J., & Andrews, M. L. (1998) · Circulation · doi:10.1161/01.cir.97.5.451 · Cited by 270
Self-citationThe Response of the QT Interval to the Brief Tachycardia Provoked by Standing
Viskin, S., Postema, P. G., Bhuiyan, Z. A., Rosso, R., Kalman, J. M., Vohra, J. K., Guevara-Valdivia, M. E., Márquez, M. F., Kogan, E., Belhassen, B., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.015 · Cited by 231
Metadata
- Authors
- Merri, M., Moss, A. J., Benhorin, J., Locati, E. H., Alberti, M., & Badilini, F.
- Affiliations
- University of Rochester (US)
- Venue
- Circulation
- Published
- 1992-05
- Volume
- 85
- Issue
- 5
- Pages
- 1816-1821
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2158611746
- Cited by
- 174
- References
- 9
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 2 · 2012: 3
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 33843, R01HL033843)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- long QT syndrome, ventricular repolarization, T wave, RR interval, beta-blockers, Holter monitoring, computational algorithms
- MeSH terms
- Adult, Diagnosis, Computer-Assisted, Electrophysiology, Female, Heart, Heart Ventricles, Humans, Long QT Syndrome, Male, Reference Values, Regression Analysis, Time Factors, Electrocardiography, Ambulatory
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