The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dilatation in patients with asymptomatic systolic dysfunction. SOLVD (Studies of Left Ventricular Dysfunction) Investigators.
Abstract
BACKGROUND: Patients with heart failure and reduced left ventricular (LV) ejection fraction (EF) manifest progressive LV dilatation, which is prevented by angiotensin converting enzyme (ACE) inhibitors. In patients with asymptomatic LV systolic dysfunction, in whom there is less activation of the renin-angiotensin system, ventricular remodeling might be less rapid and the benefit of ACE inhibitors less discernible. METHODS AND RESULTS: One hundred eight patients enrolled in the Studies of Left Ventricular Dysfunction (SOLVD) Prevention Trial, with left ventricular ejection fraction < or = 0.35 but without clinical heart failure, underwent radionuclide ventriculograms, and 49 underwent left heart catheterizations. Measurements were made before and after double-blinded randomization to enalapril (2.5 to 20 mg/d) or placebo. Repeated-measures analysis of all time points showed significant differences for change in end-diastolic volume (EDV) between enalapril and placebo groups. Significant difference between the enalapril and placebo groups (P < .05) was present for change in EDV at 1 year within the catheterization study and at a mean of 25 months within the radionuclide study. Radionuclide EDV increased in placebo patients (119 +/- 28 to 124 +/- 33 mL/m2, mean +/- SD) and decreased in enalapril patients (120 +/- 25 to 113 +/- 25 mL/m2). Differences between the two groups were significantly less than previously described in patients with symptomatic heart failure (P < .02), with less increase in LV volumes in the placebo group and less decrease in volumes in the enalapril group. CONCLUSIONS: Chronic ACE inhibitor treatment slows or reverses LV dilatation in patients with asymptomatic LV systolic dysfunction. Compared with symptomatic patients, asymptomatic patients manifest a slower rate of spontaneous LV dilatation and less reduction in LV volumes by enalapril.
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“Thus, when modeling the response to antihypertensive therapies, the influence of angiotensin II on cardiac muscle must be taken into account to simulate decrease in blood pressure without increasing heart rate, which, for instance, is the standard effect of such RAAS inhibitors as aliskiren, losartan, and enalapril (Konstam et al., 1993; Kamishirado et al., 1997; González-Abraldes et al., 2001;”
From Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease (2021) · cites this paper as Konstam et al., 1993
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Cites
The SOLVD Investigators* (1991) · New England Journal of Medicine · doi:10.1056/nejm199108013250501 · Cited by 8,029
Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911
(1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271003 · Cited by 3,725
Francis, G. S., Benedict, C. R., Johnstone, D. E., Kirlin, P. C., Nicklas, J. M., Liang, C., Kubo, S. H., Rudin-Toretsky, E., & Yusuf, S. (1990) · Circulation · doi:10.1161/01.cir.82.5.1724 · Cited by 1,386
Effect of Captopril on Progressive Ventricular Dilatation after Anterior Myocardial Infarction
Pfeffer, M. A., Lamas, G. A., Vaughan, D. E., Parisi, A. F., & D, E. B. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807143190204 · Cited by 1,101
Left ventricular remodeling after myocardial infarction: a corollary to infarct expansion.
McKay, R. G., Pfeffer, M. A., Pasternak, R. C., Markis, J. E., Come, P. C., Nakao, S., Alderman, J. D., Ferguson, J., Safian, R. D., & Grossman, W. (1986) · Circulation · doi:10.1161/01.cir.74.4.693 · Cited by 729
Konstam, M. A., Rousseau, M. F., Kronenberg, M. W., Udelson, J. E., Melin, J., Stewart, D., Dolan, N., Edens, T. R., Ahn, S. A., & Kinan, D. (1992) · Circulation · doi:10.1161/01.cir.86.2.431 · Cited by 605
Self-citationRegional Cardiac Dilatation after Acute Myocardial Infarction
Eaton, L. W., Weiss, J. L., Bulkley, B. H., Garrison, J. B., & Weisfeldt, M. L. (1979) · New England Journal of Medicine · doi:10.1056/nejm197901113000202 · Cited by 549
FLETCHER, P. J., Pfeffer, J. M., Pfeffer, M. A., & D, E. B. M. (1981) · Circulation Research · doi:10.1161/01.res.49.3.618 · Cited by 363
A modified method for the in vivo labeling of red blood cells with Tc-99m: concise communication.
Callahan, R. J., FROELICH, J. W., McKusick, K. A., Leppo, J. A., & Strausś, H. W. (1982) · PubMed · Cited by 324
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Cohn, J. N., Ferrari, R., & Sharpe, N. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00630-0 · Cited by 2,161
Ndumele, C. E., Neeland, I. J., Tuttle, K. R., Chow, S. L., Mathew, R. O., Khan, S. S., Coresh, J., Baker-Smith, C. M., Carnethon, M. R., Després, J.-P., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001186 · Cited by 1,405
Spinale, F. G. (2007) · Physiological Reviews · doi:10.1152/physrev.00012.2007 · Cited by 1,139
Impact of Aortic Stiffness Attenuation on Survival of Patients in End-Stage Renal Failure
Guérin, A. P., Blacher, J., Pannier, B., Marchais, S. J., Safar, M. E., & London, G. M. (2001) · Circulation · doi:10.1161/01.cir.103.7.987 · Cited by 1,038
Left Ventricular Remodeling in Heart Failure
Konstam, M. A., Kramer, D. G., Patel, A. R., Maron, M. S., & Udelson, J. E. (2011) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2010.10.008 · Cited by 808
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Metadata
- Authors
- Konstam, M. A., Kronenberg, M. W., Rousseau, M. F., Udelson, J. E., Melin, J., Stewart, D., Dolan, N., Edens, T. R., Ahn, S., & Kinan, D.
- Affiliations
- Tufts University (US)
- Venue
- Circulation
- Published
- 1993-11
- Volume
- 88
- Issue
- 5
- Pages
- 2277-2283
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1981884097
- Cited by
- 316
- References
- 22
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 11 · 2022: 2 · 2021: 7 · 2020: 9 · 2019: 10 · 2018: 7 · 2017: 17 · 2016: 5 · 2015: 3 · 2014: 9 · 2013: 6 · 2012: 10
- FWCI
- 7.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc055010-009)
- National Heart, Lung, and Blood Institute (N01-HC-55010)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- enalapril, ACE inhibitors, left ventricular dilatation, left ventricular systolic dysfunction, asymptomatic heart failure, ventricular remodeling, end-diastolic volume, left ventricular ejection fraction, renin-angiotensin system, heart failure prevention
- MeSH terms
- Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Blood Volume, Enalapril, Female, Cardiac Catheterization, Heart Diseases, Humans, Male, Middle Aged, Systole, Time Factors, Vasodilation, Radionuclide Ventriculography, Ventricular Function, Left
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