The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Angiotensin-Converting Enzyme in the Human Heart: Effect of the Deletion/Insertion Polymorphism
Abstract
Background An insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been associated with differences in the plasma levels of ACE as well as with myocardial infarction, cardiomyopathy, left ventricular hypertrophy, and coronary artery disease. Methods and Results We determined the cardiac ACE activity and the ACE genotype in 71 subjects who died of noncardiac disorders. Cardiac ACE activity was significantly higher ( P <.01) in subjects with the ACE DD genotype (12.7±1.9 mU/g wet wt) compared with subjects with the ID (8.7±0.8 mU/g) and the II (9.1±1.0 mU/g) genotypes. This difference was independent of sex, age, and the time required for tissue collection. Conclusions Cardiac ACE activity is highest in subjects with the DD genotype. Elevated cardiac ACE activity in these subjects may result in increased cardiac angiotensin II levels, and this may be a mechanism underlying the reported association between the ACE deletion polymorphism and the increased risk for several cardiovascular disorders.
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Cites
Rigat, B., Hubert, C., Alhenc-Gelas, F., Cambien, F., Corvol, P., & Soubrier, F. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114844 · Cited by 3,767
Cited by
Montgomery, H. E., Clarkson, P., Dollery, C. M., Prasad, K., Losi, M.-A., Hemingway, H., Statters, D., Jubb, M., Girvain, M., Varnava, A., et al. (1997) · Circulation · doi:10.1161/01.cir.96.3.741 · Cited by 362
Type 1 diabetes and coronary artery disease
Orchard, T. J., Costacou, T., Kretowski, A., & Nesto, R. W. (2006) · Diabetes Care · doi:10.2337/dc06-1161 · Cited by 305
[18] Peptidyl dipeptidase A: Angiotensin I-converting enzyme
Corvol, P., Williams, T. A., & Soubrier, F. (1995) · Methods in Enzymology · doi:10.1016/0076-6879(95)48020-x · Cited by 277
Genes and human elite athletic performance
MacArthur, D. G., & North, K. N. (2005) · Human Genetics · doi:10.1007/s00439-005-1261-8 · Cited by 229
The ACE Gene and Human Performance: 12 Years On
Puthucheary, Z., Skipworth, J. R. A., Rawal, J., Loosemore, M., Van Someren, K., & Montgomery, H. E. (2011) · Sports Medicine · doi:10.2165/11588720-000000000-00000 · Cited by 220
Metadata
- Authors
- Danser, A. H. J., Schalekamp, M. A. D. H., Bax, W. A., van den Brink, A. M., Saxena, P. R., Riegger, G. A. J., & Schunkert, H.
- Venue
- Circulation
- Published
- 1995-09-15
- Volume
- 92
- Issue
- 6
- Pages
- 1387-1388
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2068359901
- Cited by
- 761
- References
- 1
- FWCI
- 21.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Angiotensin-Converting Enzyme in the Human Heart: Effect of the Deletion/Insertion Polymorphism. https://app.cochat.ai/papers/10.1161/01.cir.92.6.1387
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- Danser, A. H. J., Schalekamp, M. A. D. H., Bax, W. A., van den Brink, A. M., Saxena, P. R., Riegger, G. A. J., & Schunkert, H. (1995). Angiotensin-Converting Enzyme in the Human Heart: Effect of the Deletion/Insertion Polymorphism. Circulation. https://doi.org/10.1161/01.cir.92.6.1387
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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