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Cited by 425

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Dysfunctional Voltage-Gated K + Channels in Pulmonary Artery Smooth Muscle Cells of Patients With Primary Pulmonary Hypertension

Open access
Yuan, Jason Xiao-Jian, Aldinger, Ann M., Juhaszova, Magdalena, Wang, Jian, Conte, John V., Gaine, Sean P., Orens, Jonathan B., Rubin, Lewis J.·1998·Circulation
DOI 10.1161/01.cir.98.14.1400
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Abstract

Background —Primary pulmonary hypertension (PPH) is a rare disease of unknown cause. Although PPH and secondary pulmonary hypertension (SPH) share many clinical and pathological characteristics, their origins may be disparate. In pulmonary artery smooth muscle cells (PASMCs), the activity of voltage-gated K + (K V ) channels governs membrane potential (E m ) and regulates cytosolic free Ca 2+ concentration ([Ca 2+ ] cyt ). A rise in [Ca 2+ ] cyt is a trigger of vasoconstriction and a stimulus of smooth muscle proliferation. Methods and Results —Fluorescence microscopy and patch clamp techniques were used to measure [Ca 2+ ] cyt , E m , and K V currents in PASMCs. Mean pulmonary arterial pressures were comparable (46±4 and 53±4 mm Hg; P =0.30) in SPH and PPH patients. However, PPH-PASMCs had a higher resting [Ca 2+ ] cyt than cells from patients with SPH and nonpulmonary hypertension disease. Consistently, PPH-PASMCs had a more depolarized E m than SPH-PASMCs. Furthermore, K V currents were significantly diminished in PPH-PASMCs. Because of the dysfunctional K V channels, the response of [Ca 2+ ] cyt to the K V channel blocker 4-aminopyridine was significantly attenuated in PPH-PASMCs, whereas the response to 60 mmol/L K + was comparable to that in SPH-PASMCs. Conclusions —These results indicate that K V channel function in PPH-PASMCs is inhibited compared with SPH-PASMCs. The resulting membrane depolarization and increase in [Ca 2+ ] cyt lead to pulmonary vasoconstriction and PASMC proliferation. Our data suggest that defects in PASMC K V channels in PPH patients may be a unique mechanism involved in initiating and maintaining pulmonary vasoconstriction and appear to play a role in the pathogenesis of PPH.

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Metadata

Authors
Yuan, J. X.-J., Aldinger, A. M., Juhaszova, M., Wang, J., Conte, J. V., Gaine, S. P., Orens, J. B., & Rubin, L. J.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1998-10-06
Volume
98
Issue
14
Pages
1400-1406
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.98.14.1400
OpenAlex
W2091965408
Cited by
425
References
23
FWCI
14.55
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Dysfunctional Voltage-Gated K + Channels in Pulmonary Artery Smooth Muscle Cells of Patients With Primary Pulmonary Hypertension. https://app.cochat.ai/papers/10.1161/01.cir.98.14.1400
The paper
Yuan, J. X.-J., Aldinger, A. M., Juhaszova, M., Wang, J., Conte, J. V., Gaine, S. P., Orens, J. B., & Rubin, L. J. (1998). Dysfunctional Voltage-Gated K + Channels in Pulmonary Artery Smooth Muscle Cells of Patients With Primary Pulmonary Hypertension. Circulation. https://doi.org/10.1161/01.cir.98.14.1400

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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