The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone
Abstract
Resistance arteries exist in a maintained contracted state from which they can dilate or constrict depending on need. In many cases, these arteries constrict to membrane depolarization and dilate to membrane hyperpolarization and Ca-channel blockers. We discuss recent information on the regulation of arterial smooth muscle voltage-dependent Ca channels by membrane potential and vasoconstrictors and on the regulation of membrane potential and K channels by vasodilators. We show that voltage-dependent Ca channels in the steady state can be open and very sensitive to membrane potential changes in a range that occurs in resistance arteries with tone. Many synthetic and endogenous vasodilators act, at least in part, through membrane hyperpolarization caused by opening K channels. We discuss evidence that these vasodilators act on a common target, the ATP-sensitive K (KATP) channel that is inhibited by sulfonylurea drugs. We propose the following hypotheses that presently explain these findings: 1) arterial smooth muscle tone is regulated by membrane potential primarily through the voltage dependence of Ca channels; 2) many vasoconstrictors act, in part, by opening voltage-dependent Ca channels through membrane depolarization and activation by second messengers; and 3) many vasodilators work, in part, through membrane hyperpolarization caused by KATP channel activation.
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Cites
Multiple types of neuronal calcium channels and their selective modulation
Tsien, R. W., Lipscombe, D., Madison, D. V., Bley, K. R., & Fox, A. P. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90194-4 · Cited by 1,381
Intracellular ATP directly blocks K+ channels in pancreatic B-cells
Cook, D. L., & Hales, N. (1984) · Nature · doi:10.1038/311271a0 · Cited by 1,208
Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells
Ashcroft, F. M., Harrison, D. E., & Ashcroft, S. J. H. (1984) · Nature · doi:10.1038/312446a0 · Cited by 1,113
Cited by
Signal transduction and regulation in smooth muscle
Somlyo, A. P., & Somlyo, A. V. (1994) · Nature · doi:10.1038/372231a0 · Cited by 1,902
Signaling Mechanisms Underlying the Vascular Myogenic Response
Davis, M. J., & Hill, M. A. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.387 · Cited by 992
Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow
Longden, T. A., Dabertrand, F., Koide, M., Gonzales, A. L., Tykocki, N. R., Brayden, J. E., Hill-Eubanks, D., & Nelson, M. T. (2017) · Nature Neuroscience · doi:10.1038/nn.4533 · Cited by 522
Self-citationRode, B., Shi, J., Endesh, N., Drinkhill, M. J., Webster, P. J., Lotteau, S. J., Bailey, M. A., Yuldasheva, N. Y., Ludlow, M. J., Cubbon, R. M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00429-3 · Cited by 305
JAGGAR, WELLMAN, HEPPNER, PORTER, PEREZ, GOLLASCH, KLEPPISCH, RUBART, STEVENSON, LEDERER, et al. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.00462.x · Cited by 302
Metadata
- Authors
- Nelson, M. T., Patlak, J. B., Worley, J. F., & Standen, N. B.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1990-07-01
- Volume
- 259
- Issue
- 1
- Pages
- C3-C18
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W134363133
- Cited by
- 1,096
- References
- 3
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nelson, M. T., Patlak, J. B., Worley, J. F., & Standen, N. B. (1990). Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.1990.259.1.c3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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