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Direct In Vivo Visualization of Intravascular Destruction of Microbubbles by Ultrasound and its Local Effects on Tissue
Open accessAbstract
Background—Our aim was to observe ultrasound-induced intravascular microbubble destruction in vivo and to characterize any resultant bioeffects. Methods and Results—Intravital microscopy was used to visualize the spinotrapezius muscle in 15 rats during ultrasound delivery. Microbubble destruction during ultrasound exposure caused rupture of ≤7-μm microvessels (mostly capillaries) and the production of nonviable cells in adjacent tissue. The number of microvessels ruptured and cells damaged correlated linearly (P<0.001) with the amount of ultrasound energy delivered. Conclusions—Microbubbles can be destroyed by ultrasound, resulting in a bioeffect that could be used for local drug delivery, angiogenesis, and vascular remodeling, or for tumor destruction.
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Citations
Cited by
Microbubbles in ultrasound-triggered drug and gene delivery
Hernot, S., & Klibanov, A. L. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.005 · Cited by 990
Microbubbles and ultrasound: from diagnosis to therapy
DIJKMANS, P., JUFFERMANS, L., MUSTERS, R., VANWAMEL, A., TENCATE, F., VANGILST, W., VISSER, C., DEJONG, N., & KAMP, O. (2004) · European Journal of Echocardiography · doi:10.1016/j.euje.2004.02.001 · Cited by 420
Acoustic behavior of microbubbles and implications for drug delivery
Kooiman, K., Vos, H. J., Versluis, M., & de Jong, N. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.03.003 · Cited by 401
Hynynen, K., McDannold, N., Martin, H., Jolesz, F. A., & Vykhodtseva, N. (2003) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(02)00741-x · Cited by 144
Cavitation properties of block copolymer stabilized phase-shift nanoemulsions used as drug carriers
Rapoport, N., Christensen, D. A., Kennedy, A. M., & Nam, K.-H. (2010) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2009.11.009 · Cited by 79
Metadata
- Authors
- Skyba, D. M., Price, R. J., Linka, A. Z., Skalak, T. C., & Kaul, S.
- Venue
- Circulation
- Published
- 1998-07-28
- Volume
- 98
- Issue
- 4
- Pages
- 290-293
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1976082197
- Cited by
- 474
- References
- 0
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Skyba, D. M., Price, R. J., Linka, A. Z., Skalak, T. C., & Kaul, S. (1998). Direct In Vivo Visualization of Intravascular Destruction of Microbubbles by Ultrasound and its Local Effects on Tissue. Circulation. https://doi.org/10.1161/01.cir.98.4.290
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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