Cavitation properties of block copolymer stabilized phase-shift nanoemulsions used as drug carriers
Open accessAbstract
Cavitation properties of block copolymer stabilized perfluoropentane nanoemulsions have been investigated. The nanoemulsions were stabilized by two biodegradable amphiphilic block copolymers differing in the structure of the hydrophobic block, poly(ethylene oxide)-co-poly(L-lactide) (PEG-PLLA) and poly(ethylene oxide)-co-polycaprolactone (PEG-PCL). Cavitation parameters were measured in liquid emulsions and gels as a function of ultrasound pressure for unfocused or focused 1-MHz ultrasound. Acoustic droplet vaporization preceded generation of acoustic cavitation in liquid matrices and gels. Both stable and inertial cavitation was observed for focused ultrasound while only stable cavitation was observed for unfocused ultrasound.
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Common emulsifiers for nanoemulsions include lecithin, sodium deoxycholate, Tween 20/40/60/80, Span 20/40/60/80, poloxamers, sodium dodecyl sulfate, casein, polysaccharides and PEG-containing block copolymers.
“Lecithin (phosphatidylcholine) [36], sodium deoxycholate (bile salt) [37], polyoxyethlene sorbitan monolaurate (Tween 20, 40, 60, 80) [38] and sorbitan monolaurate (Span 20, 40, 60, 80) [39] are commonly employed in the preparation of NEs. Other surfactants proposed are poloxamers [40], sodium dodecyl sulfate [41], amphiphilic proteins like casein [42], polysaccharides (starch derivatives, gums) [”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [44]
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- Authors
- Rapoport, N., Christensen, D. A., Kennedy, A. M., & Nam, K.-H.
- Affiliations
- University of Utah (US)
- Corresponding author
- Rapoport, Natalya
- ORCID
- Kennedy, Anne M.
- Venue
- Ultrasound in Medicine & Biology
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 36
- Issue
- 3
- Pages
- 419-429
- ISSN
- 0301-5629 (ISSN-L)
- PMC
- PMC2826577
- OpenAlex
- W2132621668
- Cited by
- 79
- References
- 41
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 1 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 2 · 2013: 9 · 2012: 4
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Ultrasound in Medicine & Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R01EB001033, R56EB001033)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Materials Chemistry › Ultrasound and Cavitation Phenomena
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- cavitation, perfluoropentane, drug carriers, PEG-PCL, acoustic droplet vaporization, inertial cavitation, stable cavitation, focused ultrasound, ultrasound pressure, emulgel
- MeSH terms
- Drug Carriers, Drug Stability, Emulsions, Lactates, Particle Size, Polyesters, Polyethylene Glycols, Drug Delivery Systems, Phase Transition, Microbubbles, Nanoparticles
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