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Cited by 144Cardiac Structural Anomalies and RepairCardiac Fibrosis and RemodelingCardiac Ischemia and Reperfusion

Restraining infarct expansion preserves left ventricular geometry and function after acute anteroapical infarction

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Kelley, Scott T., Malekan, Ramin, Gorman, Joseph H., Jackson, Benjamin M., Gorman, Robert C., Suzuki, Yasuyuki, Plappert, Theodore, Bogen, Daniel K. +2 more·1999·Circulation
DOI 10.1161/01.cir.99.1.135
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Abstract

Background —Expansion of an acute myocardial infarction predicts progressive left ventricular (LV) dilatation, functional deterioration, and early death. This study tests the hypothesis that restraining expansion of an acute infarction preserves LV geometry and resting function. Methods and Results —In 23 sheep, snares were placed around the distal left anterior descending and second diagonal coronary arteries. In 12 sheep, infarct deformation was prevented by Marlex mesh placed over the anticipated myocardial infarct. Snared arteries were occluded 10 to 14 days later. Serial hemodynamic measurements and transdiaphragmatic quantitative echocardiograms were obtained up to 8 weeks after anteroapical infarction of 0.23 of LV mass. In sheep with mesh, circulatory hemodynamics, stroke work, and end-systolic elastance return to preinfarction values 1 week after infarction and do not change subsequently. Ventricular volumes and ejection fraction do not change after the first week postinfarction. Control animals develop large anteroapical ventricular aneurysms, increasing LV dilatation, and progressive deterioration in circulatory hemodynamics and ventricular function. At week 8, differences in LV end-diastolic pressure, cardiac output, end-diastolic and end-systolic volumes, ejection fraction, stroke work, and end-systolic elastance are significant ( P <0.01) between groups. Conclusions —Preventing expansion of acute myocardial infarctions preserves LV geometry and function.

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  • Various disease types can be developed in sheep, including myocardial infarction, gradual aortic constriction, and tachypacing induced heart failure.

    “Various disease types can be developed in sheep, including, but not limited to myocardial infarction (Kelley, et al., 1999; Kramer, et al., 1993), gradual aortic constriction (Aoyagi, et al., 1993; Moorjani, et al., 2003), and tachypacing induced heart failure (Byrne, et al., 2002).”

    From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Kelley, et al., 1999

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Authors
Kelley, S. T., Malekan, R., Gorman, J. H., Jackson, B. M., Gorman, R. C., Suzuki, Y., Plappert, T., Bogen, D. K., Sutton, M. G. S. J., & Edmunds, L. H.
Affiliations
University of Pennsylvania (US)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1999-01-12
Volume
99
Issue
1
Pages
135-142
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.99.1.135
OpenAlex
W4244872663
Cited by
144
References
12
Citations by year
2024: 3 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 7 · 2017: 3 · 2016: 6 · 2015: 11 · 2014: 5 · 2013: 11 · 2012: 8
FWCI
4.51
Type
journal article
Language
en
Open access
Locations
Circulation (publishedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL-36308)
Topics
  • Health Sciences › Medicine › Surgery › Cardiac Structural Anomalies and Repair
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Keywords
acute myocardial infarction, infarct expansion, left ventricular geometry, left ventricular function, ventricular aneurysm, Marlex mesh, coronary artery occlusion, end-systolic elastance, ejection fraction, ventriculomegaly, sheep model

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