Cited by 611Cardiac Arrhythmias and TreatmentsCardiac electrophysiology and arrhythmiasAtrial Fibrillation Management and Outcomes

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Catheter Ablation of Accessory Pathways, Atrioventricular Nodal Reentrant Tachycardia, and the Atrioventricular Junction: Final Results of a Prospective, Multicenter Clinical Trial

Calkins, Hugh, Yong, Patrick, Miller, John M., Olshansky, Brian, Carlson, Mark, Saul, J. Philip, Huang, Shoei K. Stephen, Liem, L. Bing, Klein, Lawrence S., Moser, Suzan A., Bloch, Daniel A., Gillette, Paul, Prystowsky, Eric·1999·Circulation

DOI 10.1161/01.cir.99.2.262

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Abstract

BACKGROUND: The purpose of this study was to evaluate the safety and efficacy of a temperature-controlled radiofrequency catheter ablation system. METHODS AND RESULTS: The patient population included 1050 patients who had undergone ablation of atrioventricular nodal reentrant tachycardia (AVNRT), an accessory pathway (AP), or the atrioventricular junction (AVJ). Ablation was successful in 996 patients. The probability of success was highest among patients who had undergone ablation of the AVJ, lowest in patients who had undergone ablation of an AP, and in between for patients who had undergone ablation of AVNRT. A major complication occurred in 32 patients. Four variables predicted ablation success (AVJ, AVNRT, or left free wall AP ablation and an experienced center). Four factors predicted arrhythmia recurrence (right free wall, posteroseptal, septal, and multiple APs). Two variables predicted development of a complication (structural heart disease and the presence of multiple targets), and 3 variables predicted an increased risk of death (heart disease, lower ejection fraction, and AVJ ablation). CONCLUSIONS: These findings may serve as a guide to clinicians considering therapeutic options in patients who are candidates for ablation.

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Authors: Calkins, H., Yong, P., Miller, J. M., Olshansky, B., Carlson, M., Saul, J. P., Huang, S. K. S., Liem, L. B., Klein, L. S., Moser, S. A., Bloch, D. A., Gillette, P., & Prystowsky, E.
Affiliations: Johns Hopkins University (US)
ORCID: Calkins, Hugh
Miller, John M.
Olshansky, Brian
Saul, J. Philip
Bloch, Daniel A.
Prystowsky, Eric
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-01-19
Volume: 99
Issue: 2
Pages: 262-270
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.99.2.262
OpenAlex: W1976325049
Cited by: 611
References: 36
Citations by year: 2026: 2 · 2025: 7 · 2024: 10 · 2023: 10 · 2022: 8 · 2021: 22 · 2020: 21 · 2019: 19 · 2018: 12 · 2017: 27 · 2016: 19 · 2015: 32 · 2014: 14 · 2013: 37 · 2012: 35
FWCI: 22.13
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p60ar020610-19)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-20610)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Keywords: catheter ablation, accessory pathway, atrioventricular nodal reentrant tachycardia, atrioventricular junction, radiofrequency ablation, ablation success, arrhythmia recurrence, procedural complications, mortality risk factors, structural heart disease, ejection fraction
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Arrhythmias, Cardiac, Atrioventricular Node, Child, Child, Preschool, Female, Heart Conduction System, Humans, Infant, Male, Middle Aged, Prospective Studies, Recurrence, Safety, Tachycardia, Atrioventricular Nodal Reentry, Treatment Outcome, Catheter Ablation

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Catheter Ablation of Accessory Pathways, Atrioventricular Nodal Reentrant Tachycardia, and the Atrioventricular Junction: Final Results of a Prospective, Multicenter Clinical Trial

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