The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Cost-Effectiveness of Radiofrequency Ablation for Supraventricular Tachycardia
Abstract
BACKGROUND: Radiofrequency ablation is an established but expensive treatment option for many forms of supraventricular tachycardia. Most cases of supraventricular tachycardia are not life-threatening; the goal of therapy is therefore to improve the patient's quality of life. OBJECTIVE: To compare the cost-effectiveness of radiofrequency ablation with that of medical management of supraventricular tachycardia. DESIGN: Markov model. DATA SOURCES: Costs were estimated from a major academic hospital and the literature, and treatment efficacy was estimated from reports from clinical studies at major medical centers. Probabilities of clinical outcomes were estimated from the literature. To account for the effect of radiofrequency ablation on quality of life, assessments by patients who had undergone the procedure were used. TARGET POPULATION: Cohort of symptomatic patients who experienced 4.6 unscheduled visits per year to an emergency department or a physician's office while receiving long-term drug therapy for supraventricular tachycardia. TIME HORIZON: Patient lifetime. PERSPECTIVE: Societal. INTERVENTIONS: Initial radiofrequency ablation, long-term antiarrhythmic drug therapy, and treatment of acute episodes of arrhythmia with antiarrhythmic drugs. OUTCOME MEASURES: Costs, quality-adjusted life-years, life-years, and marginal cost-effectiveness ratios. RESULTS OF BASE-CASE ANALYSIS: Among patients who have monthly episodes of supraventricular tachycardia, radiofrequency ablation was the most effective and least expensive therapy and therefore dominated the drug therapy options. Radiofrequency ablation improved quality-adjusted life expectancy by 3.10 quality-adjusted life-years and reduced lifetime medical expenditures by $27 900 compared with long-term drug therapy. Long-term drug therapy was more effective and had lower costs than episodic drug therapy. RESULTS OF SENSITIVITY ANALYSIS: The findings were highly robust over substantial variations in assumptions about the efficacy and complication rate of radiofrequency ablation, including analyses in which the complication rate was tripled and efficacy was decreased substantially. CONCLUSIONS: Radiofrequency ablation substantially improves quality of life and reduces costs when it is used to treat highly symptomatic patients. Although the benefit of radiofrequency ablation has not been studied in less symptomatic patients, a small improvement in quality of life is sufficient to give preference to radiofrequency ablation over drug therapy.
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In the citing paper
“As shown in Table 20, RF ablation procedures resulted in substantial improvement of QoL and cost reduction at long term, with a highly favourable ('dominant') cost-utility profile.”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [247]
In the citing paper
“Cheng et al. compared, in a Markov model, RF ablation vs. pharmacological treatment (continuous or only at the time of arrhythmia recurrence) in highly symptomatic adult patients with monthly recurrences of SVTs, excluding patients with WPW syndrome.247”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [247]
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Cited by
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Brugada, J., Katritsis, D. G., Arbelo, E., Arribas, F., Bax, J. J., Blomström‐Lundqvist, C., Calkins, H. G., Corrado, D., Deftereos, S. G., Diller, G., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz467 · Cited by 1,312
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Metadata
- Authors
- Cheng, C. H. F., Sanders, G. D., Hlatky, M. A., Heidenreich, P., McDonald, K. M., Lee, B. K., Larson, M. S., & Owens, D. K.
- Affiliations
- VA Palo Alto Health Care System (US)
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2000-12-05
- Volume
- 133
- Issue
- 11
- Pages
- 864-876
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W1972421012
- Cited by
- 87
- References
- 77
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 8 · 2013: 2 · 2012: 5
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agency for Healthcare Research and Quality (HS08362)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Keywords
- radiofrequency ablation, supraventricular tachycardia, cost-effectiveness, antiarrhythmic therapy, quality-adjusted life years, quality of life, medical management
- MeSH terms
- Adult, Aged, Anti-Arrhythmia Agents, Cost-Benefit Analysis, Decision Trees, Direct Service Costs, Heart Block, Humans, Markov Chains, Middle Aged, Sensitivity and Specificity, Tachycardia, Supraventricular, Drug Costs, Catheter Ablation, Quality-Adjusted Life Years
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- CoChat. (2026). Citation check: Cost-Effectiveness of Radiofrequency Ablation for Supraventricular Tachycardia. https://app.cochat.ai/papers/10.7326/0003-4819-133-11-200012050-00010
- The paper
- Cheng, C. H. F., Sanders, G. D., Hlatky, M. A., Heidenreich, P., McDonald, K. M., Lee, B. K., Larson, M. S., & Owens, D. K. (2000). Cost-Effectiveness of Radiofrequency Ablation for Supraventricular Tachycardia. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-133-11-200012050-00010
