The DOI matches its Crossref record.
Cardiac-Directed Adenylyl Cyclase Expression Improves Heart Function in Murine Cardiomyopathy
Open accessAbstract
Background —We tested the hypothesis that increased cardiac myocyte adenylyl cyclase (AC) content increases cardiac function and response to catecholamines in cardiomyopathy. Methods and Results —Transgenic mice with cardiac-directed expression of AC type VI (AC VI ) were crossbred with mice with cardiomyopathy induced by cardiac-directed G q expression. G q mice had dilated left ventricles, reduced heart function, decreased cardiac responsiveness to catecholamine stimulation, and impaired β-adrenergic receptor (βAR)–dependent and AC-dependent cAMP production. G q /AC mice showed improved basal cardiac function in vivo ( P =0.01) and ex vivo ( P <0.0005). When stimulated through the βAR, cardiac responsiveness was increased ( P =0.02), and cardiac myocytes showed increased cAMP production in response to isoproterenol ( P =0.03) and forskolin ( P <0.0001). Conclusions —Increasing myocardial AC VI content in cardiomyopathy restores cAMP-generating capacity and improves cardiac function and responsiveness to βAR stimulation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Cardiac Hypertrophy: The Good, the Bad, and the Ugly
Frey, N., & Olson, E. N. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142243 · Cited by 1,449
Seven-transmembrane-spanning receptors and heart function
Rockman, H. A., Koch, W. J., & Lefkowitz, R. J. (2002) · Nature · doi:10.1038/415206a · Cited by 938
Isoforms of Mammalian Adenylyl Cyclase: Multiplicities of Signaling
Sunahara, R. K. (2002) · Molecular Interventions · doi:10.1124/mi.2.3.168 · Cited by 406
Sadana, R., & Dessauer, C. W. (2009) · Neurosignals · doi:10.1159/000166277 · Cited by 361
Xiao, R.-P. (2001) · Science's STKE · doi:10.1126/stke.2001.104.re15 · Cited by 264
Metadata
- Authors
- Roth, D. M., Gao, M. H., Lai, N. C., Drumm, J., Dalton, N., Zhou, J. Y., Zhu, J., Entrikin, D., & Hammond, H. K.
- Venue
- Circulation
- Published
- 1999-06-22
- Volume
- 99
- Issue
- 24
- Pages
- 3099-3102
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2112079413
- Cited by
- 176
- References
- 0
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cardiac-Directed Adenylyl Cyclase Expression Improves Heart Function in Murine Cardiomyopathy. https://app.cochat.ai/papers/10.1161/01.cir.99.24.3099
- The paper
- Roth, D. M., Gao, M. H., Lai, N. C., Drumm, J., Dalton, N., Zhou, J. Y., Zhu, J., Entrikin, D., & Hammond, H. K. (1999). Cardiac-Directed Adenylyl Cyclase Expression Improves Heart Function in Murine Cardiomyopathy. Circulation. https://doi.org/10.1161/01.cir.99.24.3099
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
