The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cardiac Hypertrophy: The Good, the Bad, and the Ugly
Abstract
▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical stress. While hypertrophy can eventually normalize wall tension, it is associated with an unfavorable outcome and threatens affected patients with sudden death or progression to overt heart failure. Accumulating evidence from studies in human patients and animal models suggests that in most instances hypertrophy is not a compensatory response to the change in mechanical load, but rather is a maladaptive process. Accordingly, modulation of myocardial growth without adversely affecting contractile function is increasingly recognized as a potentially auspicious approach in the prevention and treatment of heart failure. In this review, we summarize recent insights into hypertrophic signaling and consider several novel antihypertrophic strategies. The same thing that makes you live can kill you in the end. —Neil Young
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The phosphoinositide 3-kinase pathway
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Cardiac hypertrophy is not a required compensatory response to short-term pressure overload
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Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes
Nunes, S. S., Miklas, J. W., Liu, J., Aschar-Sobbi, R., Xiao, Y., Zhang, B., Jiang, J., Massé, S., Gagliardi, M., Hsieh, A., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2524 · Cited by 952
Shiojima, I. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24682 · Cited by 939
Bernardo, B. C., Weeks, K. L., Pretorius, L., & McMullen, J. R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.04.005 · Cited by 894
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Metadata
- Authors
- Frey, N., & Olson, E. N.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2003-03
- Volume
- 65
- Issue
- 1
- Pages
- 45-79
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2129439677
- Cited by
- 1,449
- References
- 5
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Frey, N., & Olson, E. N. (2003). Cardiac Hypertrophy: The Good, the Bad, and the Ugly. Annual Review of Physiology. https://doi.org/10.1146/annurev.physiol.65.092101.142243
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
