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Cited by 532Obstructive Sleep Apnea ResearchBlood Pressure and Hypertension StudiesSleep and related disorders

The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.

Obesity, Sleep Apnea, and Hypertension

Wolk, Robert, Shamsuzzaman, Abu S.M., Somers, Virend K.·2003·Hypertension
DOI 10.1161/01.hyp.0000101686.98973.a3
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Abstract

Obesity has a high and rising prevalence and represents a major public health problem. Obstructive sleep apnea (OSA) is also common, affecting an estimated 15 million Americans, with a prevalence that is probably also rising as a consequence of increasing obesity. Epidemiologic data support a link between obesity and hypertension as well as between OSA and hypertension. For example, untreated OSA predisposes to an increased risk of new hypertension, and treatment of OSA lowers blood pressure, even during the daytime. Possible mechanisms whereby OSA may contribute to hypertension in obese individuals include sympathetic activation, hyperleptinemia, insulin resistance, elevated angiotensin II and aldosterone levels, oxidative and inflammatory stress, endothelial dysfunction, impaired baroreflex function, and perhaps by effects on renal function. The coexistence of OSA and obesity may have more widespread implications for cardiovascular control and dysfunction in obese individuals and may contribute to some of the clustering of abnormalities broadly defined as the metabolic syndrome. From the clinical and therapeutic perspectives, the presence of resistant hypertension and the absence of a nocturnal decrease in blood pressure in obese individuals should prompt the clinician to consider the diagnosis of OSA, especially if clinical symptoms suggestive of OSA (such as poor sleep quality, witnessed apnea, excessive daytime somnolence, and so forth) are also present.

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Show all 85 references

Research works printed but not linked: 16

  1. 10.1161/circ.100.7.706 · DOI
  2. 10.1161/circ.89.6.8205675 · DOI
  3. 10.1161/hyp.25.4.560 · DOI
  4. 10.1161/circ.96.10.3423 · DOI
  5. 10.1161/circ.98.8.772 · DOI
  6. 10.1161/hyp.25.4.893 · DOI
  7. 10.1161/hyp.31.1.409 · DOI
  8. 10.1161/hyp.39.2.496 · DOI
  9. 10.1161/hyp.39.2.486 · DOI
  10. 10.1161/hyp.37.2.541 · DOI
  11. 10.1161/hyp.37.2.554 · DOI
  12. 10.1161/circ.102.21.2607 · DOI
  13. 10.1161/hyp.36.4.538 · DOI
  14. 10.1161/circ.98.11.1071 · DOI
  15. 10.1161/hyp.32.6.1039 · DOI
  16. 10.1161/hyp.32.2.293 · DOI

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Metadata

Authors
Wolk, R., Shamsuzzaman, A. S. M., & Somers, V. K.
Affiliations
Mayo Clinic (US)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-12
Volume
42
Issue
6
Pages
1067-1074
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.0000101686.98973.a3
OpenAlex
W2155424615
Cited by
532
References
85
Citations by year
2026: 11 · 2025: 25 · 2024: 28 · 2023: 27 · 2022: 29 · 2021: 26 · 2020: 23 · 2019: 15 · 2018: 20 · 2017: 13 · 2016: 12 · 2015: 29 · 2014: 26 · 2013: 21 · 2012: 35
FWCI
2.53
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL65176, R01HL073211, R01HL065176, HL61560, HL73211, HL 70302, R01HL070302, R01HL061560)
  • National Center for Research Resources (M01-RR00 585, M01RR000585)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
obesity, obstructive sleep apnea, resistant hypertension, metabolic syndrome, sympathetic activation, leptin, insulin resistance, angiotensin II, aldosterone, oxidative stress, endothelial dysfunction, baroreflex dysfunction, nocturnal blood pressure dipping, cardiovascular risk
MeSH terms
Adult, Aged, Humans, Hypertension, Middle Aged, Obesity, Sleep Apnea, Obstructive

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