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Cited by 68Heart Rate Variability and Autonomic ControlBlood Pressure and Hypertension StudiesSleep and Work-Related Fatigue

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Modafinil Elicits Sympathomedullary Activation

Taneja, Indu, Diedrich, Andre, Black, Bonnie K., Byrne, Daniel W., Paranjape, Sachin Y., Robertson, David·2005·Hypertension
DOI 10.1161/01.hyp.0000158267.66763.63
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Abstract

The autonomic effects of modafinil (Provigil), a psychostimulant widely used to attenuate fatigue and promote wakefulness, are currently unexplored. We assessed the effect of modafinil on autonomic nervous system. We compared oral modafinil (400 mgx1) versus placebo in 12 healthy hospitalized normal subjects in a randomized double-blind, placebo-controlled cross-over study for 3 days each with subjects in 150 mEq sodium, 70 mEq potassium balance at the Vanderbilt General Clinical Research Center. Modafinil increased resting heart rate (9.2+/-2.0 bpm; mean [+/-SE]; 95% confidence interval [CI], 4.7 to 13.6; P=0.001), resting systolic blood pressure (7.3+/-3.2 mm Hg; 95% CI, 0.2 to 14.4; P=0.044), and resting diastolic blood pressure (5.3+/-1.7 mm Hg; 95% CI, 1.4 to 9.1 mm Hg; P<0.012). Modafinil elicited a 42% higher orthostatic increase in plasma norepinephrine (0.8+/-0.3 nmol/L; 95% CI, 0.2 to 1.3; P=0.01), and caused a 33% increase in urine norepinephrine (5.1+/-1.1 nmol/L creatinine per day; 95% CI, 2.7 to 7.4, P=0.001), and an 81% increase in urine epinephrine (1.3+/-0.2 nmol/L creatinine per day; 95% CI, 1 to 2; P<0.001). The peroneal microneurographic sympathetic activity was attenuated by modafinil during orthostatic tilt (P<0.001). alpha1-Adrenoreceptor function was maintained. Modafinil substantially perturbs autonomic cardiovascular regulation by increase in heart rate and blood pressure. Autonomic changes of this magnitude encourage caution in use of modafinil in patients with cardiovascular disease.

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Crossref · 10.1161/01.hyp.0000158267.66763.63

Cites

35 of 35 references verified0 citation errors · 0 not checkable

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  • The finding that catecholamine increases were amplified by modafinil is consistent with prior reports of increased catecholamine levels with modafinil administration.

    “consistent with prior reports of increased catecholamine levels with modafinil administration (49).”

    From Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men (2010) · cites this paper as [49]

Citations

Cites

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Research works printed but not linked: 5

  1. O’Connor A. Wakefulness finds a powerful ally. The New York Times. 2004 4 AD Jun 29; section F column 2 Health & Fitness;1:D1–D6.
  2. Makris AP, Kelly TH, Rush CR, Wilson JF, Frederich RC. The effects of modafinil on food intake, verbal reports of drug effect, performance, and cardiovascular activity in normal, healthy men and women. Obes Res. 2001; 9: 181S.
  3. Crabbe JB, Rogers NL, Szuba MP, Dinges DF. Modafinil does not affect heart rate or heart rate variability from 0800 to 1200 hours during 88 hours of simulated sustained operations. Sleep. 2003; 26: A173–A174.
  4. 10.1161/circ.105.9.1054 · DOI
  5. 10.1161/hyp.34.3.461 · DOI

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Metadata

Authors
Taneja, I., Diedrich, A., Black, B. K., Byrne, D. W., Paranjape, S. Y., & Robertson, D.
Affiliations
  • Vanderbilt University (US)
  • From the Autonomic Dysfunction Center, Division of Clinical Pharmacology, Departments of Medicine, Pharmacology, Neurology, and Biostatistics, Vanderbilt University, Nashville, Tenn.
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-04
Volume
45
Issue
4
Pages
612-618
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.0000158267.66763.63
OpenAlex
W2094275595
Cited by
68
References
35
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 6 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 2
FWCI
4.51
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Vanderbilt University
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL067232, 1PO1 HL56693, P01HL056693)
  • National Center for Research Resources (RR00095)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
modafinil, autonomic nervous system, psychostimulants, heart rate, blood pressure, norepinephrine, epinephrine, orthostatic response, sympathetic activity, cardiovascular effects, fatigue
MeSH terms
Modafinil, Adrenal Medulla, Adult, Central Nervous System Stimulants, Benzhydryl Compounds, Cardiovascular System, Catecholamines, Diuresis, Double-Blind Method, Electrolytes, Female, Humans, Male, Middle Aged, Reference Values, Sympathetic Nervous System, Muscle, Skeletal, Cross-Over Studies

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