The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
An Orally Active Epoxide Hydrolase Inhibitor Lowers Blood Pressure and Provides Renal Protection in Salt-Sensitive Hypertension
Open accessAbstract
The present study tested the hypothesis that increasing epoxyeicosatrienoic acids by inhibition of soluble epoxide hydrolase (sEH) would lower blood pressure and ameliorate renal damage in salt-sensitive hypertension. Rats were infused with angiotensin and fed a normal-salt diet or an 8% NaCl diet for 14 days. The sEH inhibitor, 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), was given orally to angiotensin-infused animals during the 14-day period. Plasma AUDA metabolite levels were measured, and they averaged 10±2 ng/mL in normal-salt angiotensin hypertension and 19±3 ng/mL in high-salt angiotensin hypertension on day 14 in the animals administered the sEH inhibitor. Mean arterial blood pressure averaged 161±4 mm Hg in normal-salt and 172±5 mm Hg in the high-salt angiotensin hypertension groups on day 14. EH inhibitor treatment significantly lowered blood pressure to 140±5 mm Hg in the normal-salt angiotensin hypertension group and to 151±6 mm Hg in the high-salt angiotensin hypertension group on day 14. The lower arterial blood pressures in the AUDA-treated groups were associated with increased urinary epoxide-to-diol ratios. Urinary microalbumin levels were measured, and ED-1 staining was used to determine renal damage and macrophage infiltration in the groups. Two weeks of AUDA treatment decreased urinary microalbumin excretion in the normal-salt and high-salt angiotensin hypertension groups and macrophage number in the high-salt angiotensin hypertension group. These data demonstrate that sEH inhibition lowers blood pressure and ameliorates renal damage in angiotensin-dependent, salt-sensitive hypertension.
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Cites
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Self-citationSoluble Epoxide Hydrolase Inhibition Lowers Arterial Blood Pressure in Angiotensin II Hypertension
Imig, J. D., Zhao, X., Capdevila, J. H., Morisseau, C., & Hammock, B. D. (2002) · Hypertension · doi:10.1161/hy0202.103788 · Cited by 400
Self-citationImmunosuppressive Treatment Protects Against Angiotensin II-Induced Renal Damage
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Self-citationThe Role of the Kidney in Hypertension
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Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II
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Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.
Zhao, X., Yamamoto, T., Newman, J. W. I., Kim, I.-H., Watanabe, T., Hammock, B. D., Stewart, J. P., Pollock, J. S., Pollock, D. M., & Imig, J. D. (2004) · PubMed · Cited by 222
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Cited by
The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives
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Action of epoxyeicosatrienoic acids on cellular function
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Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology
Imig, J. D. (2012) · Physiological Reviews · doi:10.1152/physrev.00021.2011 · Cited by 365
Self-citationMerabet, N., Bellien, J., Glevarec, E., Nicol, L., Lucas, D., Remy-Jouet, I., Bounoure, F., Dreano, Y., Wecker, D., Thuillez, C., et al. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.11.015 · Cited by 63
Metadata
- Authors
- Imig, J. D., Zhao, X., Zaharis, C. Z., Olearczyk, J. J., Pollock, D. M., Newman, J. W., Kim, I.-H., Watanabe, T., & Hammock, B. D.
- Venue
- Hypertension
- Published
- 2005-10
- Volume
- 46
- Issue
- 4
- Pages
- 975-981
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2170664051
- Cited by
- 257
- References
- 27
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Imig, J. D., Zhao, X., Zaharis, C. Z., Olearczyk, J. J., Pollock, D. M., Newman, J. W., Kim, I.-H., Watanabe, T., & Hammock, B. D. (2005). An Orally Active Epoxide Hydrolase Inhibitor Lowers Blood Pressure and Provides Renal Protection in Salt-Sensitive Hypertension. Hypertension. https://doi.org/10.1161/01.hyp.0000176237.74820.75
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