Soluble epoxide hydrolase inhibition improves myocardial perfusion and function in experimental heart failure
Abstract
The study addressed the hypothesis that soluble epoxide hydrolase (sEH) inhibition, which increases cardiovascular protective epoxyeicosatrienoic acids (EETs), exerts beneficial effects in an established chronic heart failure (CHF) model. In CHF rats, left ventricular (LV) function, perfusion and remodeling were assessed using MRI and invasive hemodynamics after 42-day (starting 8 days after coronary ligation) and delayed 3-day (starting 47 days after coronary ligation) treatments with the sEH inhibitor AUDA (twice 0.25 mg/day). Delayed 3-day and 42-day AUDA increased plasma EETs demonstrating the effective inhibition of sEH. Delayed 3-day and 42-day AUDA enhanced cardiac output without change in arterial pressure, thus reducing total peripheral resistance. Both treatment periods increased the slope of the LV end-systolic pressure-volume relation, but only 42-day AUDA decreased LV end-diastolic pressure, relaxation constant Tau and the slope of the LV end-diastolic pressure-volume relation, associated with a reduced LV diastolic volume and collagen density. Delayed 3-day and, to a larger extent, 42-day AUDA increased LV perfusion associated with a decreased LV hypoxia-inducible factor-1alpha. Both treatment periods decreased reactive oxygen species level and increased reduced-oxidized glutathione ratio. Finally, MSPPOH, an inhibitor of the EET-synthesizing enzyme cytochrome epoxygenases, abolished the beneficial effects of 3-day AUDA on LV function and perfusion. Augmentation of EET availability by pharmacological inhibition of sEH increases LV diastolic and systolic functions in established CHF. This notably results from short-term processes, i.e. increased LV perfusion, reduced LV oxidative stress and peripheral vasodilatation, but also from long-term effects, i.e. reduced LV remodeling.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Various signs of increased oxidative stress have been reported in heart failure, ventricular hypertrophy, myocardial infarction, diabetes, and other conditions.
“Various signs of increased oxidative stress have been reported in various cardiovascular-related diagnoses such as heart failure (Dai et al. 2012), ventricular hypertrophy (Dai et al. 2011), myocardial infarction (Merabet et al. 2012), diabetes (Anderson et al. 2009) and other conditions.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Merabet et al. 2012
Cites
Eplerenone in patients with systolic heart failure and mild symptoms
Zannad, F., McMurray, J. J. V., Krum, H., van Veldhuisen, D. J., Swedberg, K., Shi, H., Vincent, J., Pocock, S. J., & Pitt, B. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1009492 · Cited by 3,111 · see citing works
Pfeffer, M. A., & D, E. B. M. (1990) · Circulation · doi:10.1161/01.cir.81.4.1161 · Cited by 2,873 · see citing works
Long-term trends in the incidence of and survival with heart failure
Levy, D., Kenchaiah, S., Larson, M. G., Benjamin, E. J., Kupka, M. J., Ho, K. K. L., Murabito, J. M., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020265 · Cited by 2,152 · see citing works
Ventricular Remodeling after Myocardial Infarction
Mitchell, G. F., Lamas, G. A., & Pfeffer, M. A. (1993) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2946-0_25 · Cited by 756 · see citing works
Pfeffer, M. A., Pfeffer, J. M., Steinberg, C., & Finn, P. V. (1985) · Circulation · doi:10.1161/01.cir.72.2.406 · Cited by 717 · see citing works
Heart Failure Incidence and Survival (from the Atherosclerosis Risk in Communities Study)
Loehr, L. R., Rosamond, W. D., Chang, P. P., Folsom, A. R., & Chambless, L. E. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.11.061 · Cited by 712 · see citing works
Litwin, S. E., Katz, S. E., Morgan, J. P., & Douglas, P. S. (1994) · Circulation · doi:10.1161/01.cir.89.1.345 · Cited by 420 · see citing works
Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix
Kandasamy, A. D., Chow, A. K., Ali, M. A., & Schulz, R. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp268 · Cited by 289 · see citing works
Imig, J. D., Zhao, X., Zaharis, C. Z., Olearczyk, J. J., Pollock, D. M., Newman, J. W. I., Kim, I.-H., Watanabe, T., & Hammock, B. D. (2005) · Hypertension · doi:10.1161/01.hyp.0000176237.74820.75 · Cited by 260 · see citing works
Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors
Xu, D., Li, N., He, Y., Timofeyev, V., Lü, L., Tsai, H.-J., Kim, I.-H., Tuteja, D., Mateo, R. K. P., Singapuri, A., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609158103 · Cited by 235 · see citing works
Measurement of circulating nitrite and S-nitrosothiols by reductive chemiluminescence
MacArthur, P. H., Shiva, S., & Gladwin, M. T. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.12.012 · Cited by 229 · see citing works
Orally Bioavailable Potent Soluble Epoxide Hydrolase Inhibitors
Hwang, S. H., Tsai, H.-J., Liu, J., Morisseau, C. H. P., & Hammock, B. D. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070270t · Cited by 225 · see citing works
Monti, J., Fischer, J., Paskaš, S., Heinig, M., Schulz, H., Gösele, C., Heuser, A., Fischer, R., Schmidt, C., Schirdewan, A., et al. (2008) · Nature Genetics · doi:10.1038/ng.129 · Cited by 176 · see citing works
Dhanasekaran, A., Gruenloh, S. K., Buonaccorsi, J. N., Zhang, R., Gross, G. J., Falck, J. R., Patel, P. K., Jacobs, E. R., & Medhora, M. M. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00979.2007 · Cited by 164 · see citing works
Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy
Ai, D., Pang, W., Li, N., Xu, M., Jones, P. D., Yang, J., Zhang, Y., Chiamvimonvat, N., Shyy, J. Y.-J., Hammock, B. D., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811022106 · Cited by 155 · see citing works
Epoxyeicosatrienoic acids, cell signaling and angiogenesis
Fleming, I. (2006) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2006.05.003 · Cited by 132 · see citing works
Mulder, P. G. H., Mellin, V., Favre, J., Vercauteren, M., Rémy‐Jouet, I., Monteil, C., Richard, V. J., Renet, S., Henry, J. P., Jeng, A. Y., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn277 · Cited by 126 · see citing works
Self-citationFraccarollo, D., Widder, J. D., Galuppo, P., Thum, T., Tsikas, D., Hoffmann, M., Ruetten, H., Ertl, G., & Bauersachs, J. K. (2008) · Circulation · doi:10.1161/circulationaha.107.717702 · Cited by 120 · see citing works
Liu, Y.-H., Carretero, O. A., Cingolani, O. H., Liao, T., Sun, Y., Xu, J., Li, L. Y., Pagano, P. J., Yang, J. J., & Yang, X.-P. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00546.2005 · Cited by 118 · see citing works
Vascular Cytochrome P450 Enzymes: Physiology and Pathophysiology
Fleming, I. (2008) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2007.11.002 · Cited by 103 · see citing works
Kober, F., Iltis, I., Izquierdo, M., Desrois, M., Ibarrola, D., Cozzone, P. J., & Bernard, M. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10676 · Cited by 95 · see citing works
Mellin, V., Isabelle, M., Oudot, A., Vergely, C., Monteil, C., Meglio, B. D., Henry, J., Dautréaux, B., Rochette, L., Thuillez, C., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi305 · Cited by 90 · see citing works
Self-citationLi, N., Liu, J., Timofeyev, V., Qiu, H., Hwang, S. H., Tuteja, D., Lü, L., Yang, J., Mochida, H., Low, R., et al. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.08.017 · Cited by 87 · see citing works
Banquet, S., Gomez, É., Nicol, L., Edwards‐Lévy, F., Henry, J., Cao, R., Schapman, D., Dautréaux, B., Lallemand, F., Bauer, F., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.010264 · Cited by 84 · see citing works
Self-citationBauer, W. R., Hiller, K., Roder, F., Rommel, E., Ertl, G., & Haase, A. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350107 · Cited by 79 · see citing works
Vercauteren, M., Rémy, E., Devaux, C., Dautréaux, B., Henry, J., Bauer, F., Mulder, P. G. H., van Huijsduijnen, R. H., Bombrun, A., Thuillez, C., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.630129 · Cited by 72 · see citing works
Self-citationSoluble Epoxide Hydrolase in Atherosclerosis
Wang, Y.-X. J., Ulu, A., Zhang, L.-N., & Hammock, B. D. (2010) · Current Atherosclerosis Reports · doi:10.1007/s11883-010-0108-5 · Cited by 70 · see citing works
Fang, X., Hu, S., Watanabe, T., Weintraub, N. L., Snyder, G. D., Yao, J., Liu, Y., Shyy, J. Y.-J., Hammock, B. D., & Spector, A. A. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.085605 · Cited by 70 · see citing works
Saito, T., Hu, F., Tayara, L., Fahas, L., Shennib, H., & Giaid, A. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00596.2001 · Cited by 56 · see citing works
Bellien, J., Joannidès, R., Richard, V. J., & Thuillez, C. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.03.015 · Cited by 54 · see citing works
Self-citationEpoxyeicosatrienoic Acids and/or Their Metabolites Promote Hypoxic Response of Cells
Suzuki, S., Oguro, A., Osada‐Oka, M., Funae, Y., & Imaoka, S. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08122fp · Cited by 47 · see citing works
Jiang, J. G., Chen, R. J., Xiao, B., Yang, S., Wang, J. N., Wang, Y., Cowart, L. A., Xiao, X., Wang, D. W., & Xia, Y. (2006) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2006.08.005 · Cited by 44 · see citing works
Improvement of left ventricular diastolic function induced by β-blockade
Fang, Y., Nicol, L., Harouki, N., Monteil, C., Wecker, D., Debunne, M., Bauer, F., Lallemand, F., Richard, V. J., Thuillez, C., et al. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.05.012 · Cited by 28 · see citing works
Self-citationGao, J., Bellien, J., Gomez, É., Henry, J., Dautréaux, B., Bounoure, F., Skiba, M., Thuillez, C., & Richard, V. J. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e328345ef7b · Cited by 25 · see citing works
Self-citationGoulitquer, S., Dréano, Y., Berthou, F., Corcos, L., & Lucas, D. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.10.035 · Cited by 23 · see citing works
Self-citationLiclican, E. L., Doumad, A. B., Wang, J., Li, J., Falck, J. R., Stier, C. T., & Carroll, M. A. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.123570 · Cited by 19 · see citing works
Fang, Y., Favre, J., Vercauteren, M., Laillet, B., Rémy‐Jouet, I., Skiba, M., Lallemand, F., Dehaudt, C., Monteil, C., Thuillez, C., et al. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2010.00839.x · Cited by 17 · see citing works
Self-citationYan, L., Lu, L., Wang, H., Zeng, X., & Zhang, L.-K. (2005) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
Wang, B., Wu, L., Chen, J., Dong, L., Chen, C., Zheng, W., Hu, J., Fleming, I., & Wang, D. W. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00443-w · Cited by 1,467 · see citing works
Oxidative Stress in Cardiovascular Diseases
Dubois‐Deruy, E., Peugnet, V., Turkieh, A., & Pinet, F. (2020) · Antioxidants · doi:10.3390/antiox9090864 · Cited by 667 · see citing works
Soluble epoxide hydrolase: Gene structure, expression and deletion
Harris, T. R., & Hammock, B. D. (2013) · Gene · doi:10.1016/j.gene.2013.05.008 · Cited by 235 · see citing works
Cytochrome P450-derived eicosanoids and heart function
Jamieson, K. L., Endo, T. H., Darwesh, A. M., Samokhvalov, V., & Seubert, J. M. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.05.005 · Cited by 119 · see citing works
Epoxyeicosatrienoic Acid Pathway in Human Health and Diseases
Bellien, J., & Joannidés, R. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318273b007 · Cited by 92 · see citing works
Self-citationProspective for cytochrome P450 epoxygenase cardiovascular and renal therapeutics
Imig, J. D. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.06.015 · Cited by 89 · see citing works
Inside epoxyeicosatrienoic acids and cardiovascular disease
Tacconelli, S., & Patrignani, P. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00239 · Cited by 70 · see citing works
Epoxyeicosatrienoic acids and cardioprotection: The road to translation
Oni‐Orisan, A., Alsaleh, N. B., Lee, C. R., & Seubert, J. M. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.05.016 · Cited by 65 · see citing works
Cao, J. J., Singh, S. P., McClung, J. A., Joseph, G. U., Vanella, L., Barbagallo, I. A., Jiang, H., Falck, J. R., Arad, M., Shapiro, J. I., et al. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00093.2017 · Cited by 65 · see citing works
Cai, Z., Zhao, G., Yan, J., Liu, W., Feng, W., Ma, B., Yang, L., Wang, J.-A., Tu, L., & Wang, D. W. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m036533 · Cited by 62 · see citing works
The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling
Lai, J.-S., & Chen, C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.642470 · Cited by 53 · see citing works
Gupta, N. C., Davis, C. M., Nelson, J. W., Young, J. M., & Alkayed, N. J. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.251520 · Cited by 59 · see citing works
Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS
Lee, Y., & Im, E. (2021) · Antioxidants · doi:10.3390/antiox10030377 · Cited by 59 · see citing works
Besnier, M., Galaup, A., Nicol, L., Henry, J., Coquerel, D., Gueret, A., Mulder, P. G. H., Bråkenhielm, E., Thuillez, C., Germain, S., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-245753 · Cited by 56 · see citing works
Self-citationRoche, C., Besnier, M., Cassel, R., Harouki, N., Coquerel, D., Guerrot, D., Nicol, L., Loizon, E., Rémy‐Jouet, I., Morisseau, C. H. P., et al. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00465.2014 · Cited by 56 · see citing works
Self-citationMyocardial arterial spin labeling
Kober, F., Jao, T. R., Troalen, T., & Nayak, K. S. (2016) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-016-0235-4 · Cited by 53 · see citing works
Acun, A., Nguyen, T. D., & Zorlutuna, P. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.064 · Cited by 50 · see citing works
Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria
Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T.-L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., et al. (2017) · Cell chemical biology · doi:10.1016/j.chembiol.2017.08.009 · Cited by 51 · see citing works
Epoxyeicosatrienoic Acid as Therapy for Diabetic and Ischemic Cardiomyopathy
Romashko, M. D., Schragenheim, J., Abraham, N. G., & McClung, J. A. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.08.001 · Cited by 50 · see citing works
Moon, S. H., Liu, X., Cedars, A. M., Yang, K., Kiebish, M. A., Joseph, S. M., Kelley, J., Jenkins, C. M., & Gross, R. W. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000405 · Cited by 49 · see citing works
Mitochondrial Dysfunction and Inflammaging in Heart Failure: Novel Roles of CYP-Derived Epoxylipids
Keshavarz-Bahaghighat, H., Darwesh, A. M., Sosnowski, D. K., & Seubert, J. M. (2020) · Cells · doi:10.3390/cells9071565 · Cited by 49 · see citing works
McClung, J. A., Levy, L., Garcia, V. G., Stec, D. E., Peterson, S. J., & Abraham, N. G. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107975 · Cited by 47 · see citing works
Duflot, T., Roche, C., Lamoureux, F., Guerrot, D., & Bellien, J. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.881354 · Cited by 42 · see citing works
Self-citationYang, L., Ni, L., Duan, Q., Wang, X., Chen, C., Chen, S., Chaugai, S., Zeldin, D. C., Tang, J. R., & Wang, D. W. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.01.004 · Cited by 39 · see citing works
Liang, Y., Jing, Z., Deng, H., Li, Z., Zhuang, Z., Wang, S., & Wang, Y. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.05.020 · Cited by 39 · see citing works
Dewey, S., Lai, X., Witzmann, F. A., Sohal, M., & Gomes, A. V. (2013) · Journal of Proteome Research · doi:10.1021/pr4004739 · Cited by 35 · see citing works
Akhnokh, M. K., Yang, F. H., Samokhvalov, V., Jamieson, K. L., Cho, W. J., Wagg, C. S., Takawale, A. R., Wang, X., Lopaschuk, G. D., Hammock, B. D., et al. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00133 · Cited by 35 · see citing works
Elkhatib, M. A. W., Isse, F. A., & El‐Kadi, A. O. S. (2022) · Drug Metabolism Reviews · doi:10.1080/03602532.2022.2162075 · Cited by 33 · see citing works
Červenka, L., Melenovský, V., Husková, Z., Sporková, A., Bürgelová, M., Škaroupková, P., HWANG, S. H., Hammock, B. D., Imig, J. D., & Sadowski, J. (2015) · Physiological Research · doi:10.33549/physiolres.932977 · Cited by 31 · see citing works
Roche, C., Guerrot, D., Harouki, N., Duflot, T., Besnier, M., Rémy‐Jouet, I., Renet, S., Dumesnil, A., Lejeune, A., Morisseau, C. H. P., et al. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.04.011 · Cited by 29 · see citing works
Self-citationShim, C. Y., Kim, S., Chadderdon, S. M., Wu, M. D., Qi, Y., Xie, A., Alkayed, N. J., Davidson, B. P., & Lindner, J. R. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00216.2014 · Cited by 28 · see citing works
Peugnet, V., Chwastyniak, M., Mulder, P. G. H., Lancel, S., Bultot, L., Fourny, N., Renguet, E., Bugger, H., Beseme, O., Loyens, A., et al. (2022) · Antioxidants · doi:10.3390/antiox11040723 · Cited by 26 · see citing works
Self-citationJamieson, K. L., Samokhvalov, V., Akhnokh, M. K., Lee, K., Cho, W. J., Takawale, A. R., Wang, X., Kassiri, Z., & Seubert, J. M. (2017) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2017.01.001 · Cited by 26 · see citing works
Neckář, J., Khan, A. H., Gross, G. J., Cyprová, M., Hrdlička, J., Kvasilová, A., Falck, J. R., Campbell, W. B., Sedláková, L., Škutová, Š., et al. (2019) · Clinical Science · doi:10.1042/cs20180728 · Cited by 26 · see citing works
Morgan, L. A., Olzinski, A. R., Upson, J. J., Zhao, S., Wang, T., Eisennagel, S., Hoang, B. Q., Tunstead, J. R., Marino, J. P., Willette, R. N., et al. (2012) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31827fe59c · Cited by 25 · see citing works
The apoptosis-resistance in t-AUCB-treated glioblastoma cells depends on activation of Hsp27
Li, J., Hu, W., & Lan, Q. (2012) · Journal of Neuro-Oncology · doi:10.1007/s11060-012-0963-8 · Cited by 25 · see citing works
Liu, W., Wang, T., He, X., Liu, X., Wang, B., Liu, Y., Li, Z., Tan, R., Ding, C., Wang, H., et al. (2016) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000371 · Cited by 25 · see citing works
Vanella, L., Canestraro, M., Lee, C. R., Cao, J. J., Zeldin, D. C., Schwartzman, M. L., & Abraham, N. G. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.04.004 · Cited by 22 · see citing works
Peng, L., Song, Z., Zhao, C., Abuduwufuer, K., Wang, Y., Zheng, W., Ni, L., Li, C., Yu, Y., Zhu, Y., et al. (2022) · Phenomics · doi:10.1007/s43657-022-00069-8 · Cited by 21 · see citing works
Hrdlička, J., Neckář, J., Papoušek, F., Husková, Z., Kikerlová, S., Vaňourková, Z., Vernerová, Z., Akat, F., Vašinová, J., Hammock, B. D., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00159 · Cited by 19 · see citing works
Liu, X., Qin, Z., Liu, C., Song, M., Luo, X., Zhao, H., Qian, D., Chen, J., & Huang, L. J. (2019) · Vascular Pharmacology · doi:10.1016/j.vph.2019.01.001 · Cited by 18 · see citing works
Role of epoxyeicosatrienoic acids in cardiovascular diseases and cardiotoxicity of drugs
Zhang, Y., Gao, L., Yao, B., Huang, S., Zhang, Y., Liu, J., Liu, Z., & Wang, X. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121122 · Cited by 17 · see citing works
Takai, K., Chiyo, N., Nakajima, T., Nariai, T., Ishikawa, C., Nakatani, S., Ikeno, A., Yamamoto, S., & Sone, T. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.02.076 · Cited by 17 · see citing works
Bukhari, I. A., Almotrefi, A. A., Mohamed, O., Al‐Masri, A. A., & Sheikh, S. A. (2017) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12342 · Cited by 18 · see citing works
le Besnerais, M., Favre, J., Denis, C. V., Mulder, P. G. H., Martinet, J., Nicol, L., Levesque, H., Veyradier, A., Kopić, A., Motto, D. G., et al. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13439 · Cited by 14 · see citing works
Self-citationLeow, J. W. H., & Chan, E. C. Y. (2024) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2024.108637 · Cited by 12 · see citing works
Zhang, K., Wang, J., Zhang, H., Chen, J., Zuo, Z., Wang, J., & Huang, H. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.12.025 · Cited by 11 · see citing works
Messaoudi, H., Lévesque, T., Perzo, N., Berg, E., Feugray, G., Dumesnil, A., Brunel, V., Guerrot, D., Eltchaninoff, H., Richard, V. J., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041539 · Cited by 9 · see citing works
Self-citationSoluble Epoxide Hydrolase Inhibition Prevents Experimental Type 4 Cardiorenal Syndrome
Hamzaoui, M., Roche, C., Coquerel, D., Duflot, T., Brunel, V., Mulder, P. G. H., Richard, V. J., Bellien, J., & Guerrot, D. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.604042 · Cited by 9 · see citing works
Self-citationYousef, A., Fang, L., Heidari, M., Kranrod, J. W., & Seubert, J. M. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1486717 · Cited by 7 · see citing works
Duflot, T., Tu, L., Leuillier, M., Messaoudi, H., Groussard, D., Feugray, G., Azhar, S., Thuillet, R., Bauer, F., Humbert, M. J. C., et al. (2021) · Metabolites · doi:10.3390/metabo11110784 · Cited by 6 · see citing works
Self-citationEETs mediate cardioprotection of salvianolic acids through MAPK signaling pathway
Wang, S., Zhang, W., Pang, X., Li, L., He, G., Yang, X., Fang, L., Zhang, J., & Du, G. (2013) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2012.12.006 · Cited by 5 · see citing works
Hamzaoui, M., Guerrot, D., Djerada, Z., Duflot, T., Richard, V. J., & Bellien, J. (2018) · Annales de Cardiologie et d Angéiologie · doi:10.1016/j.ancard.2018.04.018 · Cited by 3 · see citing works
Self-citationRecent Developments in Small Animal Cardiovascular MRI
Kober, F., Troalen, T., & Bernard, M. (2014) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-013-9249-6 · Cited by 2 · see citing works
Chen, S., Zhang, C., & Yu, Y. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1625064 · Cited by 1 · see citing works
Oni‐Orisan, A. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/w552-8s55
Restore mitophagy is essential to prevent cardiac oxidative stress during hypertrophyPreprint
Peugnet, V., Chwastyniak, M., Lancel, S., Bultot, L., Fourny, N., Beseme, O., Loyens, A., Heyse, W., Amouyel, P., Bertrand, L., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.12.426366
The apoptosis-resistance in t-AUCB-treated glioblastoma cells depends on activation of Hsp27
LiWeixing, J., & Lan, H. (2012)
Cardioprotective Effects of Soluble Epoxide Hydrolase Inhibition Following Myocardial Infarction
Jamieson, K. L. (2020) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-ha5a-nh95
(2013) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328360f5be
Lee, P. H. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.05.011
Perfusion MRI in the heart: Arterial spin labeling
Aramendía‐Vidaurreta, V., & Kober, F. (2023) · Advances in magnetic resonance technology and applications · doi:10.1016/b978-0-323-95209-5.00008-8
- Authors
- Merabet, N., Bellien, J., Glevarec, E., Nicol, L., Lucas, D., Remy-Jouet, I., Bounoure, F., Dreano, Y., Wecker, D., Thuillez, C., & Mulder, P.
- Affiliations
- Inserm (FR)
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 52
- Issue
- 3
- Pages
- 660-666
- ISSN
- 0022-2828 (ISSN-L)
- OpenAlex
- W1977307022
- Cited by
- 63
- References
- 38
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 6 · 2012: 5
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular and Cellular Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- auDA Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- soluble epoxide hydrolase inhibition, epoxyeicosatrienoic acids, chronic heart failure, myocardial perfusion, left ventricular function, left ventricular remodeling, AUDA, cytochrome P450 epoxygenase, reactive oxygen species, oxidative stress, hypoxia-inducible factor-1α, peripheral vasodilation, cardiac output, collagen density
- MeSH terms
- Adamantane, Animals, Coronary Circulation, Disease Models, Animal, Enzyme Inhibitors, Epoxide Hydrolases, Heart Failure, Hemodynamics, Lauric Acids, Male, Myocardial Infarction, Myocardium, Nitric Oxide, Signal Transduction, Ventricular Function, Left, Rats, Wistar, Oxidative Stress, Phosphatidylinositol 3-Kinases, Ventricular Remodeling, Proto-Oncogene Proteins c-akt, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review