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Cited by 196Blood Pressure and Hypertension StudiesInflammatory mediators and NSAID effectsSodium Intake and Health

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Non-Narcotic Analgesic Dose and Risk of Incident Hypertension in US Women

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Forman, John P., Stampfer, Meir J., Curhan, Gary C.·2005·Hypertension
DOI 10.1161/01.hyp.0000177437.07240.70
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Abstract

Acetaminophen, ibuprofen, and aspirin are the most commonly used drugs in the United States. Although the frequency of their use has been associated with hypertension, prospective data examining the dose of these drugs and risk of hypertension are lacking. Furthermore, whether certain indications for analgesic use, particularly headache, mediate the association is unclear. We conducted 2 prospective cohort studies among older women 51 to 77 years of age (n=1903) from the Nurses’ Health Study I and younger women 34 to 53 years of age (n=3220) from the Nurses’ Health Study II who completed detailed supplemental questionnaires pertaining to their analgesic use and who did not have hypertension at baseline. We analyzed incident hypertension according to categories of average daily dose of acetaminophen, nonsteroidal anti-inflammatory drugs, and aspirin. Information on indications for analgesic use as well as relevant confounders was also gathered prospectively. Compared with women who did not use acetaminophen, the multivariable adjusted relative risk for those who took >500 mg per day was 1.93 (1.30 to 2.88) among older women and 1.99 (1.39 to 2.85) among younger women. For nonsteroidal anti-inflammatory drugs, similar comparisons yielded multivariable relative risks of 1.78 (1.21 to 2.61) among older women and 1.60 (1.10 to 2.32) among younger women. These associations remained significant among women who did not report headache. Aspirin dose was not significantly associated with hypertension. Higher daily doses of acetaminophen and nonsteroidal anti-inflammatory drugs independently increase the risk of hypertension in women. Because acetaminophen and nonsteroidal anti-inflammatory drugs are commonly used, they may contribute to the high prevalence of hypertension in the United States.

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  1. 10.1161/circ.97.8.716 · DOI

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Metadata

Authors
Forman, J. P., Stampfer, M. J., & Curhan, G. C.
Affiliations
Brigham and Women's Hospital (US)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-09
Volume
46
Issue
3
Pages
500-507
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.0000177437.07240.70
OpenAlex
W2145707658
Cited by
196
References
33
Citations by year
2026: 1 · 2025: 6 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 12 · 2016: 9 · 2015: 11 · 2014: 3 · 2013: 15 · 2012: 16
FWCI
8.66
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords
non-opioid analgesics, paracetamol, nonsteroidal anti-inflammatory drugs, aspirin, drug dosing, older women, young women, headache, Nurses' Health Study
MeSH terms
Adult, Age Factors, Aged, Dose-Response Relationship, Drug, Female, Headache, Humans, Hypertension, Middle Aged, Nurses, Prospective Studies, Surveys and Questionnaires, Risk, Cohort Studies, Analgesics, Non-Narcotic

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