CoChat
Sign Up
Cited by 145Inflammatory mediators and NSAID effectsBlood Pressure and Hypertension StudiesEicosanoids and Hypertension Pharmacology

Nonnarcotic Analgesic Use and the Risk of Hypertension in US Women

Open access
Dedier, Julien, Stampfer, Meir J., Hankinson, Susan E., Willett, Walter C., Speizer, Frank E., Curhan, Gary C.·2002·Hypertension
DOI 10.1161/01.hyp.0000035856.77718.da
Open this paper in CoChat — free account

Abstract

Acetaminophen, aspirin, and other nonsteroidal anti-inflammatory drugs (NSAIDs) are widely consumed. Each is theoretically capable of elevating blood pressure by altering prostaglandin homeostasis; however, there is little prospective information on the relation between these agents and physician-diagnosed hypertension. We examined the association between the use of aspirin, acetaminophen, or NSAIDs and incident hypertension in a prospective cohort study of 51 630 women 44 to 69 years of age in 1990 who had no history of hypertension or chronic renal insufficiency. Analgesic use was assessed in 1990 by a mailed questionnaire, and the women were followed for 8 years. The primary outcome was physician-diagnosed hypertension reported on a follow-up biennial questionnaire. During 381 078 person-years of follow-up, 10 579 incident cases of hypertension were identified. Compared with nonusers, women who used aspirin or acetaminophen at least 1 day per month or NSAIDs 5 or more days per month were at a significantly higher risk for development of hypertension. After adjusting for potential confounders, the odds ratios for women in the highest frequency of use category (≥22 days per month) compared with no use were as follows: aspirin, 1.21 (95% CI, 1.13 to 1.30); acetaminophen, 1.20 (1.08 to 1.33); and NSAIDs, 1.35 (1.25 to 1.46). For each analgesic type, there was a significant trend toward an increased risk of incident hypertension with increasing frequency of use ( P <0.001). Given the observed odds ratios, biologic plausibility, and the sizeable population at risk, health professionals should consider potential hypertensive effects of aspirin, acetaminophen, and NSAIDs when counseling their patients about the use of nonnarcotic analgesics.

Integrity signals

Registry

Crossref · 10.1161/01.hyp.0000035856.77718.da

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Dedier, J., Stampfer, M. J., Hankinson, S. E., Willett, W. C., Speizer, F. E., & Curhan, G. C.
Affiliations
Brigham and Women's Hospital (US)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-11
Volume
40
Issue
5
Pages
604-608
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.0000035856.77718.da
OpenAlex
W2080325388
Cited by
145
References
23
Citations by year
2025: 1 · 2024: 6 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 10 · 2014: 6 · 2013: 8 · 2012: 7
FWCI
4.44
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
  • National Institutes of Health
  • National Cancer Institute (CA-87969, P01CA087969)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK052866, DK52866)
Topics
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords
non-opioid analgesics, aspirin, paracetamol, nonsteroidal anti-inflammatory drugs, blood pressure, prostaglandins, women, drug safety, incident hypertension risk
MeSH terms
Acetaminophen, Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Blood Pressure, Female, Follow-Up Studies, Humans, Hypertension, Middle Aged, Nurses, Prospective Studies, Surveys and Questionnaires, Risk, Risk Factors, United States, Cohort Studies, Incidence, Multivariate Analysis, Odds Ratio, Analgesics, Non-Narcotic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review