The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Abnormalities of Retinal Microvascular Structure and Risk of Mortality From Ischemic Heart Disease and Stroke
Open accessAbstract
Abnormalities of the retinal microcirculation are found in hypertension and diabetes and predict cardiovascular mortality. This study examined the relationship between abnormalities of the retinal microvasculature and death from ischemic heart disease (IHD) and stroke. A population-based, nested case-control study was undertaken within the Beaver Dam Eye Study. Subjects (43 to 74 years) who died of IHD (n=126) or stroke (n=28) over a 10-year period were age and gender matched with controls subjects (n=528; case:control matching, ≈1:4). Retinal photographs of cases and controls were digitized and analyzed using a computer-based technique. Increased risk of IHD death was associated with a suboptimal relationship of arteriolar diameters at bifurcation ( P =0.02 unadjusted) and decreased retinal arteriolar tortuosity ( P =0.011 unadjusted). These associations remained significant after adjustment for age, sex, past history of cardiovascular disease, and other known cardiovascular risk factors. Increased arteriolar length:diameter ratio, a measure of generalized arteriolar narrowing, was associated with increased stroke mortality ( P =0.02 unadjusted). This association was independent of age and gender but was attenuated by adjustment for systolic blood pressure ( P =0.15). Other quantitative measures of the retinal microvascular network (eg, venular tortuosity and arteriolar and venular bifurcation angle) were not associated with death from IHD or stroke. Retinal microvascular abnormalities are predictive of death from IHD and stroke. A detailed assessment of the retinal microvascular network from digitized photographs may be useful in the noninvasive assessment of target organ damage and cardiovascular risk.
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Cites
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Self-citationWong, T. Y., Klein, R., Couper, D. J., Cooper, L. S., Shahar, E., Hubbard, L. D., Wofford, M. R., & Sharrett, A. R. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06253-5 · Cited by 781
Self-citationOn connecting large vessels to small. The meaning of Murray's law.
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Self-citationGirard, B. (2008) · Cited by 616
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Retinal microvascular abnormalities and 10-year cardiovascular mortality
Wong, T. Y., Klein, R., Nieto, F. J., Klein, B. E. K., Sharrett, A. R., Meuer, S. M., Hubbard, L. D., & Tielsch, J. M. (2003) · Ophthalmology · doi:10.1016/s0161-6420(03)00084-8 · Cited by 347
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Cited by
Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning
Poplin, R., Varadarajan, A. V., Blumer, K., Liu, Y., McConnell, M. V., Corrado, G. S., Peng, L., & Webster, D. R. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0195-0 · Cited by 1,865
Twisted Blood Vessels: Symptoms, Etiology and Biomechanical Mechanisms
Han, H.-C. (2012) · Journal of Vascular Research · doi:10.1159/000335123 · Cited by 489
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Self-citationQuantitative and qualitative retinal microvascular characteristics and blood pressure
Cheung, C. Y., Tay, W. T., Mitchell, P., Wang, J. J., Hsu, W., Lee, M. L., Lau, Q. P., Zhu, A. L., Klein, R., Saw, S. M., et al. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e328347266c · Cited by 255
Self-citationRetinal Vascular Changes in Pre-Diabetes and Prehypertension
Nguyen, T. T., Wang, J. J., & Wong, T. Y. (2007) · Diabetes Care · doi:10.2337/dc07-0732 · Cited by 237
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Metadata
- Authors
- Witt, N., Wong, T. Y., Hughes, A. D., Chaturvedi, N., Klein, B. E., Evans, R., McNamara, M., Thom, S. A. M., & Klein, R.
- Venue
- Hypertension
- Published
- 2006-05
- Volume
- 47
- Issue
- 5
- Pages
- 975-981
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2171857332
- Cited by
- 371
- References
- 30
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Abnormalities of Retinal Microvascular Structure and Risk of Mortality From Ischemic Heart Disease and Stroke. https://app.cochat.ai/papers/10.1161/01.hyp.0000216717.72048.6c
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- Witt, N., Wong, T. Y., Hughes, A. D., Chaturvedi, N., Klein, B. E., Evans, R., McNamara, M., Thom, S. A. M., & Klein, R. (2006). Abnormalities of Retinal Microvascular Structure and Risk of Mortality From Ischemic Heart Disease and Stroke. Hypertension. https://doi.org/10.1161/01.hyp.0000216717.72048.6c
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
