The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Effects of Continuous Positive Airway Pressure Versus Supplemental Oxygen on 24-Hour Ambulatory Blood Pressure
Abstract
Obstructive sleep apnea (OSA) is associated with recurrent episodes of nocturnal hypoxia and increased risk for development of systemic hypertension. Prior studies have been limited, however, in their ability to show reduction in blood pressure after continuous positive airway pressure (CPAP) therapy, and the effect of supplemental oxygen alone on blood pressure in OSA has not been evaluated. We performed a randomized, double-blind, placebo-controlled study comparing the effects of 2 weeks of CPAP versus sham-CPAP versus supplemental nocturnal oxygen on 24-hour ambulatory blood pressure in 46 patients with moderate-severe OSA. We found that 2 weeks of CPAP therapy resulted in a significant reduction in daytime mean arterial and diastolic blood pressure and nighttime systolic, mean, and diastolic blood pressure (all P s <0.05). Although nocturnal supplemental oxygen therapy improved oxyhemoglobin saturation, it did not affect blood pressure. We conclude that CPAP therapy reduces both daytime and nighttime blood pressure in patients with OSA, perhaps through mechanisms other than improvement of nocturnal oxyhemoglobin saturation.
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Citations
Cites
Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension
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Resistant Hypertension, Obesity, Sleep Apnea, and Aldosterone: Theory and Therapy
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Sleep Apnea, Hypertension, and the Effects of Continuous Positive Airway Pressure
DHILLON, S., CHUNG, S., FARGHER, T., HUTERER, N., & SHAPIRO, C. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.11.031 · Cited by 74
Cited by
Pathophysiology of Sleep Apnea
Dempsey, J. A., Veasey, S. C., Morgan, B. J., & O'Donnell, C. P. (2010) · Physiological Reviews · doi:10.1152/physrev.00043.2008 · Cited by 2,243
Obstructive sleep apnoea and its cardiovascular consequences
Bradley, T. D., & Floras, J. S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61622-0 · Cited by 1,385
McNicholas, W. T., Bonsignore, M. R., & the Management Committee of EU COST ACTION B26 (2007) · European Respiratory Journal · doi:10.1183/09031936.00027406 · Cited by 911
Bazzano, L. A., Khan, Z., Reynolds, K., & He, J. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.085175 · Cited by 543
Long-term Effect of Continuous Positive Airway Pressure in Hypertensive Patients with Sleep Apnea
Barbé, F., Durán-Cantolla, J., Capote, F., de la Peña, M., Chiner, E., Masa, J. F., Gonzalez, M., Marín, J. M., Garcia-Rio, F., de Atauri, J. D., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200901-0050oc · Cited by 460
Metadata
- Authors
- Norman, D., Loredo, J. S., Nelesen, R. A., Ancoli-Israel, S., Mills, P. J., Ziegler, M. G., & Dimsdale, J. E.
- Venue
- Hypertension
- Published
- 2006-05
- Volume
- 47
- Issue
- 5
- Pages
- 840-845
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2143234810
- Cited by
- 187
- References
- 10
- FWCI
- 13.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effects of Continuous Positive Airway Pressure Versus Supplemental Oxygen on 24-Hour Ambulatory Blood Pressure. https://app.cochat.ai/papers/10.1161/01.hyp.0000217128.41284.78
- The paper
- Norman, D., Loredo, J. S., Nelesen, R. A., Ancoli-Israel, S., Mills, P. J., Ziegler, M. G., & Dimsdale, J. E. (2006). Effects of Continuous Positive Airway Pressure Versus Supplemental Oxygen on 24-Hour Ambulatory Blood Pressure. Hypertension. https://doi.org/10.1161/01.hyp.0000217128.41284.78
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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