Cited by 276Pregnancy and preeclampsia studiesNitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

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Endothelial Dysfunction: A Link Among Preeclampsia, Recurrent Pregnancy Loss, and Future Cardiovascular Events?

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Germain, Alfredo M., Romanik, Mary Carmen, Guerra, Irene, Solari, Sandra, Reyes, María Soledad, Johnson, Richard J., Price, Karen, Karumanchi, S. Ananth, Valdés, Gloria·2007·Hypertension

DOI 10.1161/01.hyp.0000251522.18094.d4

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Abstract

We tested the hypothesis that endothelial dysfunction could cause placentation-related defects, persist after the complicated pregnancy, and probably cause cardiovascular disease later in life. Brachial arterial reactivity and factors related to endothelial dysfunction, such as circulating cholesterol, uric acid, nitrites, l -arginine, asymmetrical dimethylarginine, vascular endothelial growth factor, and soluble vascular endothelial growth factor receptor-1, in women with previous healthy pregnancies (n=22), patients with severe preeclampsia (n=25), or patients with recurrent pregnancy loss (n=29), at day 10 of the luteal phase of an ovulatory cycle an average of 11 to 27 months after pregnancy were evaluated. Both groups with placentation defects had a significant decrease in endothelium-dependent dilatation, a higher rate of endothelial dysfunction, lower serum nitrites, and higher cholesterol as compared with control subjects; subjects with previous preeclampsia additionally had higher normal blood pressures and a greater parental prevalence of cardiovascular disease. Patients with recurrent pregnancy loss also demonstrated a significantly lower endothelium-independent vasodilatation. A trend to an inverse correlation was found between serum cholesterol serum and endothelial-mediated vasodilatation in the whole study population. Uric acid, l -arginine, asymmetrical dimethylarginine, vascular endothelial growth factor, and soluble vascular endothelial growth factor receptor-1 were similar in all of the groups. We postulate that endothelial dysfunction may represent a link between preeclampsia and increased cardiovascular disease latter in life and propose that women with unexplained recurrent miscarriages are also at increased cardiovascular risk. The identification and correction of endothelial dysfunction detected during the reproductive stage on obstetric outcome and on cardiovascular diseases needs to be elucidated.

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Authors: Germain, A. M., Romanik, M. C., Guerra, I., Solari, S., Reyes, M. S., Johnson, R. J., Price, K., Karumanchi, S. A., & Valdés, G.
Affiliations: From the Departmentos de Obstetricia/Ginecología (A.M.G., M.C.R., M.S.R.), Nefrología (G.V.), and Laboratorio Clínico (I.G., S.S.), Escuela de Medicina Pontificia Universidad Católica, Santiago, Chile; the Section of Nephrology, Hypertension, and Transplantation (R.J.J., K.P.), University of Florida, Gainsville; the Departments of Medicine and Obstetrics and Gynecology (S.A.K.), and Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, Mass.
Beth Israel Deaconess Medical Center (US)
ORCID: Guerra, Irene
Solari, Sandra
Johnson, Richard J.
Price, Karen
Karumanchi, S. Ananth
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-01
Volume: 49
Issue: 1
Pages: 90-95
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/01.hyp.0000251522.18094.d4
OpenAlex: W2159442474
Cited by: 275
References: 44
Citations by year: 2026: 8 · 2025: 6 · 2024: 23 · 2023: 14 · 2022: 20 · 2021: 9 · 2020: 14 · 2019: 24 · 2018: 11 · 2017: 24 · 2016: 7 · 2015: 8 · 2014: 20 · 2013: 20 · 2012: 15
FWCI: 9.34
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Americanae (AECID Library) (submittedVersion, other-oa)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: endothelial dysfunction, preeclampsia, recurrent pregnancy loss, brachial artery reactivity, endothelium-dependent vasodilation, endothelium-independent relaxation, serum cholesterol, uric acid, nitrite, L-arginine, asymmetric dimethylarginine, vascular endothelial growth factor, soluble VEGF receptor-1, cardiovascular risk, cardiovascular disease
MeSH terms: Abortion, Habitual, Adult, Blood Pressure, Cardiovascular Diseases, Cholesterol, Diastole, Endothelium, Vascular, Female, Humans, Medical Records, Placenta Diseases, Pre-Eclampsia, Pregnancy, Risk Factors, Severity of Illness Index, Time Factors, Vasodilation

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Endothelial Dysfunction: A Link Among Preeclampsia, Recurrent Pregnancy Loss, and Future Cardiovascular Events?

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