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The surprising kidney-fluid mechanism for pressure control--its infinite gain!
Open accessAbstract
In this short paper, I have tried to explain the elation that we felt when we first realized that the kidney-fluid mechanism for controlling the arterial pressure has an infinite feedback gain property. Because of this, all the other pressure control mechanisms, none of which has ever been shown to have a similar infinite gain property, must themselves alter the kidney-fluid mechanism if they are to succeed in causing long-term changes in the arterial pressure. We have not been able to refute this principle despite many experiments over the last 2 decades. For this reason, our first understanding of the infinite gain property of the kidney-fluid mechanism was like a light at the end of the tunnel. I hope that I can explain to the reader the excitement of those few seconds when we first recognized the principle in 1966.
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Citations
Cited by
Jiang, S.-Z., Lu, W., Zong, X.-F., Ruan, H.-Y., & Liu, Y. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3667 · Cited by 445
Impact of Salt Intake on the Pathogenesis and Treatment of Hypertension
Rust, P., & Ekmekcioglu, C. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/5584_2016_147 · Cited by 286
Hypertension: Physiology and Pathophysiology
Hall, J. E., Granger, J. P., do Carmo, J. M., da Silva, A. A., Dubinion, J., George, E., Hamza, S., Speed, J., & Hall, M. E. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110058 · Cited by 232
Mechanisms of Hypertension and Kidney Disease in Obesity
HALL, J. E., BRANDS, M. W., & HENEGAR, J. R. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07788.x · Cited by 222
Mechanisms of Abnormal Renal Sodium Handling in Obesity Hypertension
Hall, J. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(97)00075-7 · Cited by 213
Metadata
- Authors
- Guyton, A. C.
- Venue
- Hypertension
- Published
- 1990-12
- Volume
- 16
- Issue
- 6
- Pages
- 725-730
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2126758468
- Cited by
- 205
- References
- 0
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Guyton, A. C. (1990). The surprising kidney-fluid mechanism for pressure control--its infinite gain! Hypertension. https://doi.org/10.1161/01.hyp.16.6.725
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
