Hypertension: Physiology and Pathophysiology
Abstract
Despite major advances in understanding the pathophysiology of hypertension and availability of effective and safe antihypertensive drugs, suboptimal blood pressure (BP) control is still the most important risk factor for cardiovascular mortality and is globally responsible for more than 7 million deaths annually. Short‐term and long‐term BP regulation involve the integrated actions of multiple cardiovascular, renal, neural, endocrine, and local tissue control systems. Clinical and experimental observations strongly support a central role for the kidneys in the long‐term regulation of BP, and abnormal renal‐pressure natriuresis is present in all forms of chronic hypertension. Impaired renal‐pressure natriuresis and chronic hypertension can be caused by intrarenal or extrarenal factors that reduce glomerular filtration rate or increase renal tubular reabsorption of salt and water; these factors include excessive activation of the renin‐angiotensin‐aldosterone and sympathetic nervous systems, increased formation of reactive oxygen species, endothelin, and inflammatory cytokines, or decreased synthesis of nitric oxide and various natriuretic factors. In human primary (essential) hypertension, the precise causes of impaired renal function are not completely understood, although excessive weight gain and dietary factors appear to play a major role since hypertension is rare in nonobese hunter‐gathers living in nonindustrialized societies. Recent advances in genetics offer opportunities to discover gene‐environment interactions that may also contribute to hypertension, although success thus far has been limited mainly to identification of rare monogenic forms of hypertension. © 2012 American Physiological Society.Compr Physiol 2:2393‐2442, 2012.
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Activation of the renin-angiotensin-aldosterone system (RAAS) is a mediator of abnormal kidney function and increased blood pressure during development of obesity hypertension.
“2) activation of the renin-angiotensin-aldosterone system (RAAS)”
From Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms (2015) · cites this paper as [39]
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Lymphocyte responses exacerbate angiotensin II-dependent hypertension
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Angiotensin II hypertension is attenuated in interleukin-6 knockout mice
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Self-citationAldosterone Antagonism Attenuates Obesity-Induced Hypertension and Glomerular Hyperfiltration
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Self-citationThe surprising kidney-fluid mechanism for pressure control--its infinite gain!
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Role of renal NO production in the regulation of medullary blood flow
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Role of oxidative stress in angiotensin-induced hypertension
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Divergent Results Using Clinic and Ambulatory Blood Pressures
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LONG‐TERM REGULATION OF ARTERIAL BLOOD PRESSURE BY HYPOTHALAMIC NUCLEI: SOME CRITICAL QUESTIONS
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Some observations on the quantitative anatomy of the kidney
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Evidence for endothelin involvement in the response to high salt
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Angiotensin II and long-term arterial pressure regulation: the overriding dominance of the kidney.
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Self-citationAntihypertensive effect of α- and β-adrenergic blockade in obese and lean hypertensive subjects
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Migration, Blood Pressure Pattern, and Hypertension: The Yi Migrant Study
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Cyclooxygenases, the Kidney, and Hypertension
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Self-citationDarusentan: An effective endothelinA receptor antagonist for treatment of hypertension
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Self-citationHypertension in Response to Chronic Reductions in Uterine Perfusion in Pregnant Rats
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Self-citationAn Overview of Pheochromocytoma
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The role of the sympathetic nervous system in obesity-related hypertension
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Self-citationFAMILIAL HYPERALDOSTERONISM TYPE II: FIVE FAMILIES WITH A NEW VARIETY OF PRIMARY ALDOSTERONISM
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Self-citationRole of renal hemodynamics and arterial pressure in aldosterone "escape".
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Self-citationInterpreting Abnormal Proteinuria in Pregnancy
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Reconsidering the Roles of the Mineralocorticoid Receptor
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Device-Based Antihypertensive Therapy
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Is There an Unrecognized Epidemic of Primary Aldosteronism? (Pro)
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Ethnic Differences in Insulinemia and Sympathetic Tone as Links Between Obesity and Blood Pressure
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Melanocortin-4 Receptor Mediates Chronic Cardiovascular and Metabolic Actions of Leptin
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Self-citationMolecular genetics of human hypertension
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Renal and vascular oxidative stress and salt‐sensitivity of arterial pressure
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Mineralocorticoid Receptors, Salt-Sensitive Hypertension, and Metabolic Syndrome
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Role of Reactive Oxygen Species in Endothelin-Induced Hypertension
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Self-citationEffects of pioglitazone on calcium channels in vascular smooth muscle.
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Salt handling and hypertension
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Prolonged Activation of the Baroreflex Abolishes Obesity-Induced Hypertension
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Self-citationRenoprotection by ACE Inhibition or Aldosterone Blockade Is Blood Pressure–Dependent
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Autoimmune Factors Associated with Infarction of the Kidney
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Inhibition of NO Synthesis Enhances Chronic Cardiovascular and Renal Actions of Leptin
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Self-citationRecent insights into the interactions between the baroreflex and the kidneys in hypertension
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ENVIRONMENTAL AND GENETIC SOURCES OF FAMILIAL AGGREGATION OF BLOOD PRESSURE IN TECUMSEH, MICHIGAN
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Overweight and Sympathetic Overactivity in Black Americans
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Self-citationBlockade of pressure natriuresis induced by inhibition of renal synthesis of nitric oxide in dogs
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Increased renal Na-K-ATPase, NCC, and β-ENaC abundance in obese Zucker rats
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Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2015) · Circulation Research · doi:10.1161/circresaha.116.305697 · Cited by 1,360 · see citing works
Self-citationHow Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases
Kopp, W. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s216791 · Cited by 674 · see citing works
Obesity, kidney dysfunction and hypertension: mechanistic links
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0145-4 · Cited by 654 · see citing works
Self-citationFish Waste: From Problem to Valuable Resource
Coppola, D., Lauritano, C., Palma Esposito, F., Riccio, G., Rizzo, C., & de Pascale, D. (2021) · Marine Drugs · doi:10.3390/md19020116 · Cited by 592 · see citing works
Obesity, Hypertension, and Cardiac Dysfunction
Mouton, A. J., Li, X., Hall, M. E., & Hall, J. E. (2020) · Circulation Research · doi:10.1161/circresaha.119.312321 · Cited by 549 · see citing works
Self-citationThe pathophysiology of hypertension in patients with obesity
DeMarco, V. G., Aroor, A. R., & Sowers, J. R. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.44 · Cited by 545 · see citing works
Role of Hyperinsulinemia and Insulin Resistance in Hypertension: Metabolic Syndrome Revisited
da Silva, A. A., do Carmo, J. M., Li, X., Wang, Z., Mouton, A. J., & Hall, J. E. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.02.066 · Cited by 381 · see citing works
Self-citationRoohinejad, S., Koubaa, M., Barba, F. J., Saljoughian, S., Amid, M., & Greiner, R. (2017) · Food Research International · doi:10.1016/j.foodres.2016.08.016 · Cited by 360 · see citing works
Obesity, kidney dysfunction, and inflammation: interactions in hypertension
Hall, J. E., Mouton, A. J., da Silva, A. A., Omoto, A. C. M., Wang, Z., Li, X., & do Carmo, J. M. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa336 · Cited by 279 · see citing works
Self-citationThe Role of the Autonomic Nervous System in the Pathophysiology of Obesity
Guarino, D., Nannipieri, M., Iervasi, G., Taddei, S., & Bruno, R. M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00665 · Cited by 244 · see citing works
Hypertension and physical exercise: The role of oxidative stress
Larsen, M. K., & Matchkov, V. V. (2016) · Medicina · doi:10.1016/j.medici.2016.01.005 · Cited by 223 · see citing works
Seaweeds as Preventive Agents for Cardiovascular Diseases: From Nutrients to Functional Foods
Cardoso, S. M., Pereira, O. R., Seca, A. M. L., Pinto, D. C. G. A., & Silva, A. M. S. (2015) · Marine Drugs · doi:10.3390/md13116838 · Cited by 206 · see citing works
Kavishe, B. B., Biraro, S., Baisley, K. J., Vanobberghen, F. M., Kapiga, S., Munderi, P., Smeeth, L. L., Peck, R. N., Mghamba, J. M., Mutungi, G. N., et al. (2015) · BMC Medicine · doi:10.1186/s12916-015-0357-9 · Cited by 200 · see citing works
Revisiting the mechanisms of ACE inhibitory peptides from food proteins
Wu, J., Liao, W., & Udenigwe, C. C. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.07.011 · Cited by 192 · see citing works
Gut microbiota in hypertension
José, P. A., & Raj, D. S. (2015) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000149 · Cited by 187 · see citing works
Majumder, K., & Wu, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms16010256 · Cited by 168 · see citing works
Renal Dysfunction, Rather Than Nonrenal Vascular Dysfunction, Mediates Salt-Induced Hypertension
Hall, J. E. (2016) · Circulation · doi:10.1161/circulationaha.115.018526 · Cited by 152 · see citing works
Self-citationWiig, H., Luft, F. C., & Titze, J. M. (2017) · Acta Physiologica · doi:10.1111/apha.13006 · Cited by 144 · see citing works
Valensi, P. E. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01356-w · Cited by 138 · see citing works
Morris, R. C., Schmidlin, O., Sebastian, A., Tanaka, M., & Kurtz, T. W. (2016) · Circulation · doi:10.1161/circulationaha.115.017923 · Cited by 123 · see citing works
Munakata, M. (2018) · Hypertension Research · doi:10.1038/s41440-018-0053-1 · Cited by 106 · see citing works
Xie, H., Li, J., Zhu, X., Li, J., Yin, J., Ma, T., Luo, Y., He, L., Bai, Y., Zhang, G., et al. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01632-3 · Cited by 105 · see citing works
Immune Mechanisms Linking Obesity and Preeclampsia
Spradley, F. T., Palei, A. C., & Granger, J. P. (2015) · Biomolecules · doi:10.3390/biom5043142 · Cited by 96 · see citing works
Self-citationMechanisms of sodium balance: total body sodium, surrogate variables, and renal sodium excretion
Bie, P. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00363.2017 · Cited by 90 · see citing works
Majumder, K., Liang, G., Chen, Y., Guan, L. L., Davidge, S. T., & Wu, J. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500050 · Cited by 89 · see citing works
Mechanisms and treatment of obesity-related hypertension—Part 1: Mechanisms
Parvanova, A. I., Reseghetti, E., Abbate, M., & Ruggenenti, P. L. (2023) · Clinical Kidney Journal · doi:10.1093/ckj/sfad282 · Cited by 97 · see citing works
Salt-Sensitive Hypertension and the Kidney
Nishimoto, M., Griffin, K. A., Wynne, B. M., & Fujita, T. (2024) · Hypertension · doi:10.1161/hypertensionaha.123.21369 · Cited by 80 · see citing works
Device-Based Neuromodulation for Resistant Hypertension Therapy
Lohmeier, T. E., & Hall, J. E. (2019) · Circulation Research · doi:10.1161/circresaha.118.313221 · Cited by 71 · see citing works
Self-citationObesity-Induced Hypertension: Brain Signaling Pathways
do Carmo, J. M., da Silva, A. A., Wang, Z., Fang, T., Aberdein, N., Rodriguez, C. E. P. D. L., & Hall, J. E. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0658-1 · Cited by 64 · see citing works
Self-citationXie, X., Shi, X., Xun, X., & Rao, L. (2017) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2016.1235177 · Cited by 65 · see citing works
Pathophysiology and treatment of obesity‐related hypertension
Chrysant, S. G. (2019) · Journal of Clinical Hypertension · doi:10.1111/jch.13518 · Cited by 60 · see citing works
Egg Protein-Derived Bioactive Peptides: Preparation, Efficacy, and Absorption
Liao, W., Jahandideh, F., Fan, H., Son, M., & Wu, J. (2018) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2018.02.001 · Cited by 57 · see citing works
Bellizzi, S., Ali, M. M., Abalos, E., Betran, A. P., Kapila, J., Pileggi-Castro, C., Vogel, J. P., & Merialdi, M. (2016) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-016-0987-8 · Cited by 54 · see citing works
Brain Under Stress and Alzheimer’s Disease
Mravec, B., Horváthová, Ľ., & Padová, A. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0521-1 · Cited by 53 · see citing works
Ribeiro, V. T., de Souza, L. C., & Silva, A. C. S. E. (2019) · Protein and Peptide Letters · doi:10.2174/0929866527666191230103739 · Cited by 50 · see citing works
Endoplasmic reticulum stress in the pathogenesis of hypertension
Young, C. N. (2017) · Experimental Physiology · doi:10.1113/ep086274 · Cited by 50 · see citing works
Nitric Oxide and the Cardiovascular System
Bohlen, H. G. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140052 · Cited by 54 · see citing works
Chronic kidney disease: targeting prostaglandin E2receptors
Nasrallah, R., Hassouneh, R., & Hébert, R. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00224.2014 · Cited by 49 · see citing works
Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension
Yang, J., Villar, V. A. M., José, P. A., & Zeng, C. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8106 · Cited by 45 · see citing works
Endothelial Gata5 transcription factor regulates blood pressure
Messaoudi, S., He, Y., Gutsol, A. A., Wight, A. E., Hébert, R., Vilmundarson, R. O., Makrigiannis, A. P., Chalmers, J. P., Hamet, P., Tremblay, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms9835 · Cited by 44 · see citing works
Evans, R. G., & Bie, P. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00254.2015 · Cited by 43 · see citing works
Mechanisms of blood pressure salt sensitivity: new insights from mathematical modeling
Clemmer, J. S., Pruett, W. A., Coleman, T. G., Hall, J. E., & Hester, R. L. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00353.2016 · Cited by 41 · see citing works
Self-citationRuggiero, M., Ward, E. G., Smith, R., Branca, J. J. V., Noakes, D., Morucci, G., Taubmann, M., Thyer, L., & Pacini, S. (2014) · PubMed · Cited by 41 · see citing works
Genomics and Pharmacogenomics of Salt-sensitive Hypertension
Armando, I., Villar, V. A. M., & José, P. A. (2015) · Current Hypertension Reviews · doi:10.2174/1573402111999150521102331 · Cited by 41 · see citing works
Paulo, M., Costa, D. E. F. D. R., Bonaventura, D., Lunardi, C. N., & Bendhack, L. M. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200519114442 · Cited by 41 · see citing works
Quantifying and Reducing Posture-Dependent Distortion in Ballistocardiogram Measurements
Javaid, A. Q., Wiens, A. D., Fesmire, N. F., Weitnauer, M. A., & Inan, O. T. (2015) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2015.2441876 · Cited by 40 · see citing works
Normotension, hypertension and body fluid regulation: brain and kidney
Bie, P., & Evans, R. G. (2016) · Acta Physiologica · doi:10.1111/apha.12718 · Cited by 40 · see citing works
Inflammation, Autoimmunity, and Hypertension: The Essential Role of Tissue Transglutaminase
Liu, C., Kellems, R. E., & Xia, Y. (2017) · American Journal of Hypertension · doi:10.1093/ajh/hpx027 · Cited by 40 · see citing works
Masodsai, K., Lin, Y.-Y., chaunchaiyakul, R. C., Su, C., Lee, S., & Yang, A. (2019) · Nutrients · doi:10.3390/nu11030699 · Cited by 40 · see citing works
Research progress of Nedd4L in cardiovascular diseases
Li, M., Sun, G., Wang, P., Wang, W., Cao, K., Song, C., Sun, Y., Zhang, Y., & Zhang, N. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01017-1 · Cited by 38 · see citing works
Wang, Z., Zeng, C., Villar, V. A. M., Chen, S., Konkalmatt, P. R., Wang, X., Asico, L. D., Jones, J. E., Yang, Y., Sanada, H., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05962 · Cited by 39 · see citing works
CCL2 mediates early renal leukocyte infiltration during salt-sensitive hypertension
Alsheikh, A. J., Dasinger, J. H., Abais-Battad, J. M., Fehrenbach, D. J., Yang, C., Cowley, A. W., & Mattson, D. L. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00521.2019 · Cited by 36 · see citing works
Kurtz, T. W., DiCarlo, S. E., Pravenec, M., Schmidlin, O., Tanaka, M., & Morris, R. C. (2016) · Kidney International · doi:10.1016/j.kint.2016.05.032 · Cited by 36 · see citing works
Elevated blood pressure: Our family's fault? The genetics of essential hypertension.
Natekar, A., Olds, R., Lau, M. W., Min, K., Imoto, K., & Slavin, T. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i5.327 · Cited by 40 · see citing works
The Role of Deubiquitinases in Vascular Diseases
Wang, B., Cai, W., Ai, D., Zhang, X., & Liu, Y. (2019) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-019-09909-x · Cited by 34 · see citing works
Li, X. C., & Zhuo, J. L. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0668-z · Cited by 33 · see citing works
Kopp, W. (2018) · Nutrition and Metabolic Insights · doi:10.1177/1178638818773072 · Cited by 35 · see citing works
Endothelin‐1 as a master regulator of whole‐body Na + homeostasis
Speed, J. S., Heimlich, J. B., Hyndman, K. A., Fox, B. M., Patel, V., Yanagisawa, M., Pollock, J. S., Titze, J. M., & Pollock, D. M. (2015) · The FASEB Journal · doi:10.1096/fj.15-276584 · Cited by 33 · see citing works
Self-citationRenal Mechanisms of Association between Fibroblast Growth Factor 1 and Blood Pressure
Tomaszewski, M., Eales, J., Denniff, M. J., Myers, S., Chew, G. S., Nelson, C. P., Christofidou, P., Desai, A., Büsst, C., Wojnar, Ł., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014121211 · Cited by 31 · see citing works
Gastrointestinal–Renal Axis: Role in the Regulation of Blood Pressure
Yang, J., José, P. A., & Zeng, C. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.005536 · Cited by 32 · see citing works
Luo, H. L., Chen, C., Guo, L., Xu, Z., Peng, X., Wang, X., Wang, J., Wang, N., Li, C., Luo, X., et al. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.10908 · Cited by 32 · see citing works
Wang, X., Luo, H., Chen, C., Chen, K., Wang, J., Cai, Y., Zheng, S., Yang, X., Zhou, L., José, P. A., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.08.010 · Cited by 31 · see citing works
Do high-salt microenvironments drive hypertensive inflammation?
Foss, J. D., Kirabo, A., & Harrison, D. G. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00414.2016 · Cited by 31 · see citing works
G Protein–Coupled Receptor Kinases: Crucial Regulators of Blood Pressure
Yang, J., Villar, V. A. M., Armando, I., José, P. A., & Zeng, C. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003519 · Cited by 31 · see citing works
Wu, J. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c05544 · Cited by 30 · see citing works
Importance of extracellular vesicles in hypertension
Liu, Z. Z., José, P. A., Yang, J., & Zeng, C. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220974600 · Cited by 30 · see citing works
Jennings, B. L., Montanez, D. E., May, M. E., Estes, A. M., Fang, X., Yaghini, F. A., Kanu, A. J., & Malik, K. U. (2014) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-014-6510-4 · Cited by 30 · see citing works
Jiang, X., Chen, W., Liu, X., Wang, Z., Liu, Y., Felder, R. A., Gildea, J. J., José, P. A., Qin, C., & Yang, Z. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146641 · Cited by 30 · see citing works
Sex-Specific Contributions of Endothelin to Hypertension
Gohar, E. Y., & Pollock, D. M. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0856-0 · Cited by 30 · see citing works
Hall, M. E., & Hall, J. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42973-3.00005-6 · Cited by 33 · see citing works
Self-citationThe importance of the gastrorenal axis in the control of body sodium homeostasis
José, P. A., Yang, Z., Zeng, C., & Felder, R. A. (2016) · Experimental Physiology · doi:10.1113/ep085286 · Cited by 28 · see citing works
Mechanisms for the cardiovascular effects of glucagon-like peptide-1
Poudyal, H. (2015) · Acta Physiologica · doi:10.1111/apha.12604 · Cited by 28 · see citing works
Genetics of Resistant Hypertension: a Novel Pharmacogenomics Phenotype
Rouby, N. M. E., & Cooper‐DeHoff, R. M. (2015) · Current Hypertension Reports · doi:10.1007/s11906-015-0583-8 · Cited by 27 · see citing works
Circadian Control of Sodium and Blood Pressure Regulation
Soliman, R. H., & Pollock, D. M. (2021) · American Journal of Hypertension · doi:10.1093/ajh/hpab100 · Cited by 26 · see citing works
Zanaty, M., Seara, F. D. A. C., Nakagawa, P., Deng, G., Mathieu, N. M., Balapattabi, K., Karnik, S. S., Grobe, J. L., & Sigmund, C. D. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.15793 · Cited by 26 · see citing works
Association Analysis ofFOXO3Longevity Variants With Blood Pressure and Essential Hypertension
Morris, B. J., Chen, R., Donlon, T. A., Evans, D. S., Tranah, G. J., Parimi, N., Ehret, G., Newton‐Cheh, C., Seto, T. B., Willcox, D. C., et al. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv171 · Cited by 25 · see citing works
Fluid-electrolyte homeostasis requires histone deacetylase function
Hyndman, K. A., Speed, J. S., Mendoza, L. D., Allan, J. M., Colson, J. C., Sedaka, R. S., Jin, C., Jung, H. J., El-Dahr, S. S., Pollock, D. M., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.137792 · Cited by 27 · see citing works
Self-citationActivation of the Central Renin-Angiotensin System Causes Local Cerebrovascular Dysfunction
Silva, T. M. D., Modrick, M. L., Grobe, J. L., & Faraci, F. M. (2021) · Stroke · doi:10.1161/strokeaha.121.034984 · Cited by 24 · see citing works
Pathophysiology of Hypertension
Hall, J. E., Omoto, A. C. M., Wang, Z., Mouton, A. J., Li, X., & Hall, M. E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-88369-6.00005-0 · Cited by 31 · see citing works
Self-citationMultilayered Interplay Between Fructose and Salt in Development of Hypertension
Eren, Ö. C., Ortíz, A., Afşar, B., Covic, A. C., Kuwabara, M., Lanaspa, M. A., Johnson, R. J., & Kanbay, M. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.12150 · Cited by 24 · see citing works
Sun, X., Wang, M., Xu, C., Wang, S., Li, L., Zou, S., Yu, J., & Wei, Y. (2022) · Nutrients · doi:10.3390/nu14194069 · Cited by 23 · see citing works
Owens, E. A., Li, J., Reyes, B. A. S., Bockstaele, E. J. V., & Osei‐Owusu, P. (2017) · Kidney International · doi:10.1016/j.kint.2017.04.044 · Cited by 23 · see citing works
Role of complement 3 in the pathogenesis of hypertension
Chen, L., Fukuda, N., Matsumoto, T., & Abe, M. (2019) · Hypertension Research · doi:10.1038/s41440-019-0371-y · Cited by 23 · see citing works
Increased renal oxidative stress in salt-sensitive human GRK4γ486V transgenic mice
Diao, Z., Asico, L. D., Villar, V. A. M., Zheng, X., Cuevas, S., Armando, I., José, P. A., & Wang, X. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.021 · Cited by 23 · see citing works
Özbek, L., Abdel‐Rahman, S. M., Unlu, S., Güldan, M., Copur, S., Burlacu, A., Covic, A. C., & Kanbay, M. (2024) · Medicina · doi:10.3390/medicina60101668 · Cited by 22 · see citing works
Li, L., Feng, D., Luo, Z., Welch, W. J., Wilcox, C. S., & Lai, E. Y. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05631 · Cited by 22 · see citing works
Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development
Mariano, V. S., Boer, P. A., & Gontijo, J. A. R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.704819 · Cited by 20 · see citing works
Liu, C., Luo, R., Wang, W., Peng, Z., Johnson, G. V. W., Kellems, R. E., & Xia, Y. (2019) · American Journal of Hypertension · doi:10.1093/ajh/hpz018 · Cited by 22 · see citing works
Development of the Deoxycorticosterone Acetate (DOCA)-salt Hypertensive Rat Model
Pestana‐Oliveira, N., Nahey, D. B., Johnson, T. J., & Collister, J. P. (2020) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3708 · Cited by 22 · see citing works
The Renin-Angiotensin and Renal Dopaminergic Systems Interact in Normotensive Humans
Natarajan, A. R., Eisner, G. M., Armando, I., Browning, S. M., Pezzullo, J. C., Rhee, L. Q., Dajani, M. I., Carey, R. M., & José, P. A. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014100958 · Cited by 23 · see citing works
Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress
Liu, J., Yan, Y., Nie, Y., & Shapiro, J. (2017) · Antioxidants · doi:10.3390/antiox6010018 · Cited by 20 · see citing works
Aryal, D., Roy, T., Chamcheu, J. C., & Jackson, K. E. (2020) · Antioxidants · doi:10.3390/antiox10010002 · Cited by 20 · see citing works
Use of Biomarkers in the Evaluation and Treatment of Hypertensive Patients
Currie, G. E., & Delles, C. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0661-6 · Cited by 19 · see citing works
Logical Issues With the Pressure Natriuresis Theory of Chronic Hypertension
Kurtz, T. W., DiCarlo, S. E., & Morris, R. C. (2016) · American Journal of Hypertension · doi:10.1093/ajh/hpw073 · Cited by 21 · see citing works
Yu, J., Sun, M., Jiang, S., Jiang, C., Mu, G., & Tuo, Y. (2024) · Foods · doi:10.3390/foods13050641 · Cited by 19 · see citing works
de Oliveira, M. R., Silva, T. J., Barros, E., Guimarães, V. M., Baracat‐Pereira, M. C., Eller, M. R., Coimbra, J. S. D. R., & de Oliveira, E. B. (2018) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-018-2692-8 · Cited by 19 · see citing works
Anti-hypertensive mechanisms of cyclic depsipeptide inhibitor ligands for Gq/11 class G proteins
Meleka, M. M., Edwards, A. J., Xia, J., Dahlen, S. A., Mohanty, I., Medcalf, M. R., Aggarwal, S., Moeller, K. D., Mortensen, O. V., & Osei‐Owusu, P. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.012 · Cited by 19 · see citing works
Chang, J. C., Fedinec, A. L., Kuntamallappanavar, G., Leffler, C. W., Bukiya, A. N., & Dopico, A. M. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.229054 · Cited by 19 · see citing works
Identification of Circulating Proteins Associated With Blood Pressure Using Mendelian Randomization
Thériault, S., Sjaarda, J., Chong, M., Hess, S., Gerstein, H. C., & Paré, G. (2020) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.119.002605 · Cited by 18 · see citing works
Jin, H., Huang, Y., & Yang, G. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27749 · Cited by 18 · see citing works
- Authors
- Hall, J. E., Granger, J. P., do Carmo, J. M., da Silva, A. A., Dubinion, J., George, E., Hamza, S., Speed, J., & Hall, M. E.
- Affiliations
- University of Mississippi Medical Center (US)
- Venue
- Comprehensive Physiology
- Publisher
- Wiley
- Published
- 2012-10
- Volume
- 2
- Issue
- 4
- Pages
- 2393-2442
- ISSN
- 2040-4603 (ISSN-L)
- OpenAlex
- W1666369702
- Cited by
- 232
- References
- 280
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 11 · 2023: 15 · 2022: 19 · 2021: 20 · 2020: 21 · 2019: 22 · 2018: 14 · 2017: 23 · 2016: 24 · 2015: 27 · 2014: 17 · 2013: 4 · 2012: 1
- Type
- other
- Language
- en
- Open access
- closed
- Locations
- Comprehensive physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL051971)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- hypertension, blood pressure regulation, chronic hypertension, renin-angiotensin-aldosterone system, sympathetic nervous system, endothelin, reactive oxygen species, nitric oxide, natriuretic factor, glomerular filtration rate, sodium reabsorption, essential hypertension, obesity, gene-environment interaction, monogenic hypertension, cardiovascular mortality
- MeSH terms
- Blood Pressure, Female, Glomerular Filtration Rate, Humans, Hypertension, Kidney, Male, Natriuresis, Obesity, Renin-Angiotensin System, Sex Characteristics, Weight Gain, Genetic Predisposition to Disease, Feedback, Physiological, Extracellular Fluid, Gene-Environment Interaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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