The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Diabetes mellitus and hypertension.
Open accessAbstract
Diabetes mellitus and hypertension are common diseases that coexist at a greater frequency than chance alone would predict. Hypertension in the diabetic individual markedly increases the risk and accelerates the course of cardiac disease, peripheral vascular disease, stroke, retinopathy, and nephropathy. Our understanding of the factors that markedly increase the frequency of hypertension in the diabetic individual remains incomplete. Diabetic nephropathy is an important factor involved in the development of hypertension in diabetics, particularly type I patients. However, the etiology of hypertension in the majority of diabetic patients cannot be explained by underlying renal disease and remains "essential" in nature. The hallmark of hypertension in type I and type II diabetics appears to be increased peripheral vascular resistance. Increased exchangeable sodium may also play a role in the pathogenesis of blood pressure in diabetics. There is increasing evidence that insulin resistance/hyperinsulinemia may play a key role in the pathogenesis of hypertension in both subtle and overt abnormalities of carbohydrate metabolism. Population studies suggest that elevated insulin levels, which often occurs in type II diabetes mellitus, is an independent risk factor for cardiovascular disease. Other cardiovascular risk factors in diabetic individuals include abnormalities of lipid metabolism, platelet function, and clotting factors. The goal of antihypertensive therapy in the patient with coexistent diabetes is to reduce the inordinate cardiovascular risk as well as lowering blood pressure.
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Cites
Insulin Resistance in Essential Hypertension
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Cited by
Capes, S. E., Hunt, D., Malmberg, K., & Gerstein, H. C. (2000) · The Lancet · doi:10.1016/s0140-6736(99)08415-9 · Cited by 2,187
National High Blood Pressure Education Program Working Group report on hypertension in diabetes
(1994) · Hypertension · doi:10.1161/01.hyp.23.2.145 · Cited by 1,004
An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers
Sempionatto, J. R., Lin, M., Yin, L., De la paz, E., Pei, K., Sonsa-ard, T., de Loyola Silva, A. N., Khorshed, A. A., Zhang, F., Tostado, N., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00685-1 · Cited by 658
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Diabetes Mellitus and Associated Hypertension, Vascular Disease, and Nephropathy: An Update
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Self-citation
Metadata
- Authors
- Epstein, M., & Sowers, J. R.
- Venue
- Hypertension
- Published
- 1992-05
- Volume
- 19
- Issue
- 5
- Pages
- 403-418
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2114498807
- Cited by
- 600
- References
- 17
- FWCI
- 21.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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