Diabetes and cardiovascular risk factors: the Framingham study
Abstract
The impact of cardiovascular disease was compared in non-diabetics and diabetics in the Framingham cohort. In the first 20 years of the study about 6% of the women and 8% of the men were diagnosed as diabetics. The incidence of cardiovascular disease among diabetic men was twice that among non-diabetic men. Among diabetic women the incidence of cardiovascular disease was three times that among non-diabetic women. Judging from a comparison of standardized coefficients for the regression of incidence of cardiovascular disease on specified risk factors, there is no indication that the relationship of risk factors to the subsequent development of cardiovascular disease is different for diabetics and non-diabetics. This study suggests that the role of diabetes as a cardiovascular risk factor does not derive from an altered ability to contend with known risk factors.
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Epidemiological evidence shows that diabetes is an independent risk factor for the development of cardiovascular disease.
“Epidemiological evidence shows that diabetes is an independent risk factor for the development of CVD [7,11,12,13,14,15,16]”
From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [14]
Cholesterol had been linked to cardiovascular disease by the early 20th century through animal and autopsy studies.
“Cholesterol had been linked to cardiovascular disease by the early 20th century through animal and autopsy studies.71,72”
From The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective (2014) · cites this paper as [71]
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- Authors
- Kannel, W. B., & McGee, D. L.
- Affiliations
- McGill University (CA)
- Venue
- Circulation
- Published
- 1979-01
- Volume
- 59
- Issue
- 1
- Pages
- 8-13
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2085087376
- Cited by
- 1,317
- References
- 12
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 24 · 2023: 26 · 2022: 24 · 2021: 23 · 2020: 25 · 2019: 24 · 2018: 44 · 2017: 33 · 2016: 54 · 2015: 40 · 2014: 34 · 2013: 53 · 2012: 45
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Circulation
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- diabetes mellitus, cardiovascular disease, cardiovascular risk factors, incidence, sex differences, Framingham Heart Study, diabetes as risk factor
- MeSH terms
- Age Factors, Aged, Cardiovascular Diseases, Cholesterol, Coronary Disease, Female, Follow-Up Studies, Humans, Hypertension, Male, Massachusetts, Middle Aged, Rheumatic Heart Disease, Risk, Sex Factors, Diabetes Complications
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