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Cited by 256

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Effect of chronic hypertension and sympathetic denervation on wall/lumen ratio of cerebral vessels.

Open access
Hart, M N, Heistad, D D, Brody, M J·1980·Hypertension
DOI 10.1161/01.hyp.2.4.419
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Abstract

The purposes of this study were to determine whether 1) cerebral vessels undergo hypertrophy during chronic hypertension and 2) sympathetic nerves contribute to cerebral vascular changes in chronic hypertension. Morphometric studies were undertaken in stroke-prone spontaneously hypertensive rats (SP-SHR) and normotensive Wistar-Kyoto (WKY) rats. Unilateral superior cervical ganglionectomy was performed in the SP-SHR at 8 weeks of age. When the rats were approximately 13 months old, they were killed and the brain was fixed with formalin at a perfusion pressure of 80% of the rat's systolic pressure. Wall/lumen ratio was measured in approximately 1200 arteries and arterioles. In parenchymal, but not pial, cerebral vessels there was pronounced vascular hypertrophy in SP-SHR: wall/lumen ratio was 0.08 in WKY and 0.14 in SP-SHR (p < 0.05). Sympathetic denervation attenuated the development of vascular hypertrophy in SP-SHR: wall/lumen ratio was 0.14 in the innervated parenchymal vessels, and 0.10 in denervated vessels (p < 0.05). We conclude that cerebral vessels undergo hypertrophy in stroke-prone SHR and speculate that vascular hypertrophy may protect cerebral vessels by reducing wall stress in chronic hypertension. Sympathetic nerves appear to exert a trophic effect on cerebral vascular muscle in chronic hypertension.

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Metadata

Authors
Hart, M. N., Heistad, D. D., & Brody, M. J.
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1980-07
Volume
2
Issue
4
Pages
419-423
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.2.4.419
OpenAlex
W2156118126
Cited by
256
References
16
FWCI
6.78
Type
journal article
Language
en
Open access
bronze

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