The DOI matches its Crossref record; 239 of the 239 references it cites were found in a registry or an index.
The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation
Open accessAbstract
Comorbidities are a hallmark of stroke that both increase the incidence of stroke and worsen outcome. Hypertension is prevalent in the stroke population and the most important modifiable risk factor for stroke. Hypertensive disorders promote stroke through increased shear stress, endothelial dysfunction, and large artery stiffness that transmits pulsatile flow to the cerebral microcirculation. Hypertension also promotes cerebral small vessel disease through several mechanisms, including hypoperfusion, diminished autoregulatory capacity and localized increase in blood–brain barrier permeability. Preeclampsia, a hypertensive disorder of pregnancy, also increases the risk of stroke 4–5-fold compared to normal pregnancy that predisposes women to early-onset cognitive impairment. In this review, we highlight how comorbidities and concomitant disorders are not only risk factors for ischemic stroke, but alter the response to acute ischemia. We focus on hypertension as a comorbidity and its effects on the cerebral circulation that alters the pathophysiology of ischemic stroke and should be considered in guiding future therapeutic strategies.
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TGF-β Signaling: A Therapeutic Target to Reinstate Regenerative Plasticity in Vascular Dementia?
Kandasamy, M., Anusuyadevi, M., Aigner, K. M., Unger, M. S., Kniewallner, K. M., Sousa, D. M. B. D., Altendorfer, B., Mrowetz, H., Bogdahn, U., & Aigner, L. (2020) · Aging and disease · doi:10.14336/ad.2020.0222 · Cited by 77
Chiu, Y.-S., Wu, K.-J., Yu, S.-J., Wu, K.-L., Hsieh, C.-Y., Chou, Y.-S., Chen, K.-Y., Wang, Y.-S., Bae, E.-K., Hung, T.-W., et al. (2024) · Cell Transplantation · doi:10.1177/09636897241296366 · Cited by 10
Metadata
- Authors
- Cipolla, M. J., Liebeskind, D. S., & Chan, S.-L.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2018-09-10
- Volume
- 38
- Issue
- 12
- Pages
- 2129-2149
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2892168042
- Cited by
- 369
- References
- 239
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cipolla, M. J., Liebeskind, D. S., & Chan, S.-L. (2018). The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1177/0271678x18800589
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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