The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension.
Open accessAbstract
Recent studies have indicated that acute inhibition of nitric oxide biosynthesis in the rat promotes arterial hypertension and renal vasoconstriction. We evaluated the renal and systemic effects of 4-6 weeks of nitric oxide blockade in Munich-Wistar rats receiving the nitric oxide inhibitor nitro-L-arginine orally. Age-matched untreated rats were used as controls. In an additional seven rats, nitric oxide blockade was carried out in conjunction with oral administration of the novel angiotensin II antagonist losartan potassium. Tail-cuff pressure rose progressively in nitro-L-arginine-treated rats, reaching 164 +/- 6 mm Hg at 4-6 weeks, compared with 108 +/- 3 mm Hg in controls. In rats concomitantly receiving losartan, tail-cuff pressure reached 125 +/- 6 mm Hg, still elevated compared with rats receiving losartan alone (98 +/- 3 mm Hg). Nitro-L-arginine-treated rats presented marked renal vasoconstriction and hypoperfusion, as well as a 30% fall in glomerular filtration rate and a 39% increase in filtration fraction. Treatment with Losartan normalized glomerular filtration rate, but not filtration fraction or renal vascular resistance. Plasma renin activity was elevated after nitro-L-arginine treatment. Renal histological examination revealed widespread arteriolar narrowing, focal arteriolar obliteration, and segmental fibrinoid necrosis in the glomeruli. In a separate group of rats, nitro-L-arginine administered for 1 week induced hypertension that was partially reversed by acute L-arginine, but not D-arginine or L-glycine, infusions. We conclude that chronic nitric oxide blockade may constitute a new model of severe arterial hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)
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Cited by
Elevated blood pressures in mice lacking endothelial nitric oxide synthase
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NITRIC OXIDE SYNTHASE: Role in the Genesis of Vascular Disease
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Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
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Metadata
- Authors
- Ribeiro, M. O., Antunes, E., de Nucci, G., Lovisolo, S. M., & Zatz, R.
- Venue
- Hypertension
- Published
- 1992-09
- Volume
- 20
- Issue
- 3
- Pages
- 298-303
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2124284996
- Cited by
- 786
- References
- 20
- FWCI
- 12.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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