The DOI matches its Crossref record; 175 of the 175 references it cites were found in a registry or an index.
Review of Alterations in Endothelial Nitric Oxide Production in Diabetes: Protective Role of Arginine on Endothelial Dysfunction
Abstract
N itric oxide release from the endothelium plays an im- portant role in regulation of vascular tone, 1 inhibition of both platelet and leukocyte aggregation and adhesion, 1,2 and inhibition of cell proliferation. 3These properties suggest that the level of NO production by the endothelium may play a pivotal role in the regulation of vascular disease.Analysis using mass spectrometry has revealed that NO is produced by NOS from the terminal guanidino nitrogen of the precursor amino acid L-arginine. 4 Thus, utilization of L-arginine and conversion to NO may establish a regulatory site in the development of endothelial dysfunction.][7][8] These reviews have focused on factors that might contribute to defective relaxation, some of which will not be addressed in detail in this review.The purpose of the present review is to summarize evidence that specifically supports either decreased NO production by diabetic vascular endothelium and/or impaired NO-mediated endothelium-dependent relaxation.Second, this review provides reasonable alternatives to explain some of the controversies in this research area.Third, since there is growing evidence that arginine appears to have some benefits for diabetes-associated abnormalities, this review summarizes the current state of knowledge of effects of acute and chronic administration of L-arginine on diabetesinduced endothelial dysfunction and discusses potential NOdependent and -independent mechanisms whereby therapeutic intervention with L-arginine might benefit the diabetic endothelium.
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Cites
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Hyperglycemic Pseudohypoxia and Diabetic Complications
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Cited by
Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats
Fu, W. J., Haynes, T. E., Kohli, R., Hu, J., Shi, W., Spencer, T. E., Carroll, R. J., Meininger, C. J., & Wu, G. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.4.714 · Cited by 353
Arginine Therapy: A New Treatment for Pulmonary Hypertension in Sickle Cell Disease?
Morris, C. R., Morris, S. M., Hagar, W., van Warmerdam, J., Claster, S., Kepka-Lenhart, D., Machado, L., Kuypers, F. A., & Vichinsky, E. P. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200208-967oc · Cited by 329
Pathophysiology of the Diabetic Kidney
Vallon, V., & Komers, R. (2011) · Comprehensive Physiology · doi:10.1002/cphy.c100049 · Cited by 259
Lymphatic vascular integrity is disrupted in type 2 diabetes due to impaired nitric oxide signalling
Scallan, J. P., Hill, M. A., & Davis, M. J. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv117 · Cited by 147
Dietary nitrite improves insulin signaling through GLUT4 translocation
Jiang, H., Torregrossa, A. C., Potts, A., Pierini, D., Aranke, M., Garg, H. K., & Bryan, N. S. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.10.809 · Cited by 105
Metadata
- Authors
- Pieper, G. M.
- Venue
- Hypertension
- Published
- 1998-05
- Volume
- 31
- Issue
- 5
- Pages
- 1047-1060
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2096281503
- Cited by
- 355
- References
- 175
- FWCI
- 17.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pieper, G. M. (1998). Review of Alterations in Endothelial Nitric Oxide Production in Diabetes: Protective Role of Arginine on Endothelial Dysfunction. Hypertension. https://doi.org/10.1161/01.hyp.31.5.1047
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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