The DOI matches its Crossref record; 52 of the 54 references it cites were found in a registry or an index.
Estrogen Regulation of Angiotensin-Converting Enzyme mRNA
Abstract
Abstract—Estrogen replacement therapy is cardioprotective in postmenopausal women; however, the precise molecular mechanisms for this modulation are not fully elucidated. We previously showed that chronic estrogen replacement therapy reduced angiotensin-converting enzyme (ACE) activity in tissue extracts and serum with an associated reduction in plasma angiotensin II. A reverse transcriptase–polymerase chain reaction assay was developed to determine whether estrogen treatment regulates tissue ACE mRNA concentration. Total RNA was isolated from kidney cortex, kidney medulla, lung, and aorta of ovariectomized Sprague-Dawley rats after 21 days of chronic 17β-estradiol replacement therapy (5 mg pellet per rat SC) or placebo. A marked decrease in densitometric intensity ratios of amplified ACE cDNA to elongation factor-1α control cDNA was observed in all tissues from placebo-treated rats compared with the estradiol-treated rats (renal cortex: 0.29±0.04 versus 0.14±0.02; renal medulla: 0.37±0.04 versus 0.24±0.03; lung: 4.49±0.37 versus 2.49±0.59; and aorta: 0.41±0.04 versus 0.29±0.02; all P<0.05). A comparable reduction in ACE activity was detected in tissue extracts from kidney cortex, kidney medulla, and lung of hormone-treated animals. Incubation of purified rat lung ACE with 1 or 10 μmol/L 17β-estradiol had no effect on enzyme activity. These results suggest that estrogen treatment regulates tissue ACE activity by reducing ACE mRNA concentrations. Thus, the beneficial cardiovascular effects of estrogen may be mediated in part by downregulation of ACE with a consequent reduction in the circulating levels of the vasoconstrictor angiotensin II, a decrease in the metabolism of the vasodilator bradykinin, and an increase in the production of the vasorelaxant angiotensin-(1–7).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Researchers have reported that both ACE expression and activity are inhibited by estrogen in rodent models [26-29].”
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Plasma APP activity has been shown to form a continuous distribution in the general population (Cyr et al. 2001), suggesting that plasma APP activity is a complex quantitative trait likely influenced by multiple genetic loci and nongenetic factors (e.g., smoking and hormone replacement therapy [Gallagher et al. 1999]).”
From A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. (2005) · cites this paper as Gallagher et al. 1999
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Valery (1995) · doi:10.1001/jama.1995.03520270033028 · Cited by 2,320
Hypertension : pathophysiology, diagnosis, and management
Laragh, J. H., & Brenner, B. M. (1995) · Raven Press eBooks · Cited by 1,932
Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites
Paech, K., Webb, P., Kuiper, G. G. J. M., Nilsson, S., Gustafsson, J.-Å., Kushner, P. J., & Scanlan, T. S. (1997) · Science · doi:10.1126/science.277.5331.1508 · Cited by 1,861
Stampfer, M. J., & Colditz, G. A. (1991) · Preventive Medicine · doi:10.1016/0091-7435(91)90006-p · Cited by 1,611
Butcher, R. L., COLLINS, W. E., & FUGO, N. W. (1974) · Endocrinology · doi:10.1210/endo-94-6-1704 · Cited by 1,313
Estrogen and coronary heart disease in women
Barrett-Connor, E. (1991) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1991.03460140089033 · Cited by 1,241
Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex
Gaub, M., Gross-Bellard, M., Scheuer, I., Chambon, P., & Sassone‐Corsi, P. (1990) · Cell · doi:10.1016/0092-8674(90)90422-b · Cited by 467
Esther, C. R., Howard, T. E., Marino, E. M., Goddard, J. M., Capecchi, M. R., & Bernstein, K. E. (1996) · PubMed · Cited by 440
Effects of Estrogen Replacement Therapy on the Renin-Angiotensin System in Postmenopausal Women
Schunkert, H., Danser, A. H. J., Hense, H.-W., Derkx, F. H. M., Ku¨rzinger, S., & Riegger, G. A. J. (1997) · Circulation · doi:10.1161/01.cir.95.1.39 · Cited by 438
Flagged first, then by citations
2 of the 54 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–290 of 290
Yang, C., Liu, X., & Li, S. (2010) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-119 · Cited by 11
Arzneimittelassoziierte Angioödeme
Sachs, B., Meier, T., Nöthen, M. M., Stieber, C., & Stingl, J. (2018) · Der Hautarzt · doi:10.1007/s00105-017-4119-9 · Cited by 11
The heart as a target for oestrogens
Brown, L., Hoong, I., & Doggrell, S. A. (2000) · Heart Lung and Circulation · doi:10.1046/j.1444-2892.2000.009003113.x · Cited by 11
Estradiol Attenuates Angiotensin-Induced Aldosterone Secretion in Ovariectomized Rats
Roesch, D. M. (2000) · Endocrinology · doi:10.1210/en.141.12.4629 · Cited by 11
Huang, Z., Jansson, L. E., & Sjöholm, Å. (2008) · Clinical Science · doi:10.1042/cs20070386 · Cited by 10
Thirst perception, drinking, arginine vasopressin activity and associated neurohumoral factors
Aloamaka, O. E. O., Obika, L. F. O., Ozoene, J. O., & Amabebe, E. (2018) · Journal of African Association of Physiological Sciences · doi:10.13140/rg.2.2.14974.23367 · Cited by 10
Publisher, B. S. P. B. S. (2006) · Current Vascular Pharmacology · doi:10.2174/157016106778521599 · Cited by 9
Katsumata, Y., Nomura, S., Ino, K., Iwanaga, K., Kurosawa, N., Ito, T., Okada, M., Tsujimoto, M., Kikkawa, F., & Mizutani, S. (2001) · Placenta · doi:10.1053/plac.2001.0741 · Cited by 10
Varney, V., Warner, A., Ghosh, A., Nicholas, A., & Sumar, N. (2012) · Journal of Allergy · doi:10.1155/2012/258145 · Cited by 9
Huber, D. A., Bazilio, D. S., Lorenzon, F., Sehnem, S., Pacheco, L. A., Anselmo-Franci, J. A., & Lima, F. B. (2017) · Reproductive Sciences · doi:10.1177/1933719117734318 · Cited by 9
Mechanism of antihypertensive effect of Mucuna pruriens L. seed extract and its isolated compounds
Khan, M. Y., & Kumar, V. (2017) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2017-0014 · Cited by 9
Chaves, F. J., Corella, D., Sorlí, J. V., Marín-García, P., Guillén, M., & Redón, J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031058 · Cited by 9
Nielsen, A., Schauser, K., Svenstrup, B., & Poulsen, K. (2002) · Reproduction in Domestic Animals · doi:10.1046/j.1439-0531.2002.00335.x · Cited by 9
Nadalin, S., Ristič, S., Rebić, J., Jengić, V. Š., Kapović, M., & Buretić‐Tomljanović, A. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1670-y · Cited by 8
Hereditary Angioedema with and Without C1-Inhibitor Deficiency in Postmenopausal Women
Billebeau, A., Fain, O., Launay, D., Boccon‐Gibod, I., Bouillet, L., Gobert, D., Plu‐Bureau, G., & Gompel, A. (2020) · Journal of Clinical Immunology · doi:10.1007/s10875-020-00902-7 · Cited by 8
Chambers, P. W. (2022) · OALib · doi:10.4236/oalib.1108736 · Cited by 8
Dutra, S. G. V., Felix, A. C. S., Gastaldi, A. C., Facioli, T. D. P., Vieira, S., & de Souza, H. C. D. (2017) · Autonomic Neuroscience · doi:10.1016/j.autneu.2017.07.001 · Cited by 8
Nadalin, S., Flego, V., Pavlić, S. D., Volarić, D., Badovinac, A. R., Kapović, M., & Ristič, S. (2020) · Biomedical Reports · doi:10.3892/br.2020.1365 · Cited by 8
Schereider, I. R. G., Vassallo, D., & Simões, M. (2021) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13655 · Cited by 8
Renin-angiotensin-aldosterone system genes and nonarteritic anterior ischemic optic neuropathy.
Markoula, S., Giannopoulos, S., Asproudis, I., Kostoulas, C., Nikas, A., Bagli, E., Kyritsis, A. P., & Georgiou, I. A. (2011) · Europe PMC (PubMed Central) · Cited by 7
Wanda, G. J. M. K., Kretzschmar, G., Njamen, D., Fotsing, M. T., Yankep, E., & Vollmer, G. (2010) · Fitoterapia · doi:10.1016/j.fitote.2010.08.009 · Cited by 7
Caballero, T., Cabañas, R., Campos, A., Cimbollek, S., Gómez‐Traseira, C., Gonzalez‐Quevedo, T., Guilarte, M., Palomo, J. J., Larco, J., López‐Trascasa, M., et al. (2011) · Cited by 7
A clinical prescription for heart health in midlife women
SHUFELT, C. L., Dutra, E., Torbati, T., & Ramineni, T. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.11.004 · Cited by 9
Mikołajczyk-Stecyna, J., Korcz, A., Gabriel, M., Pawlaczyk, K., Oszkinis, G., & Słomski, R. (2013) · Scientific Reports · doi:10.1038/srep03771 · Cited by 6
Dubrall, D., Branding, N. L., Mathey, C. M., Weber, A., Steffens, M., Below, M., Schmid, M. C., Wedi, B., Wieczorek, D., Amann, P. M., et al. (2025) · Clinical and Translational Allergy · doi:10.1002/clt2.70058 · Cited by 6
da Silva, G. A., Atum, A. L. B., de Matos, L. P., Nasuk, G. R., de Jesus, B. C., Gouveia, T. L. F., Baltatu, O. C., Zamunér, S. R., & Silva, J. A. (2023) · Antioxidants · doi:10.3390/antiox12030541 · Cited by 5
Ahn, H. J., Moon, D. S., Kang, D. Y., Lee, J. I., Kim, D. Y., Kim, J. H., Kim, S. Y., & Bae, H. Y. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.4.537 · Cited by 5
Regulation of blood pressure is influenced by gender: A study in obese Zucker rats
Moulana, M., & Maranon, R. O. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.08.020 · Cited by 5
Estrogen and vascular resistance
Barton, M., & Lüscher, T. F. (1999) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-199906000-00009 · Cited by 5
Mohsen, M. A., Abdel-Ghany, R. H., El-Gharbawy, A., Faisal, M. M., & Zakaria, E. M. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177951 · Cited by 4
COVID-19: From Cough to Coffin
Chambers, P. W. (2022) · OALib · doi:10.4236/oalib.1108300 · Cited by 3
Ding, L., Hou, X., Ma, X., Zong, W., Lu, H., Xiang, K., & Jia, W. (2011) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31821f5eff · Cited by 4
Lorenzon, F., Simas, B. B., Gregorio, T., Anselmo-Franci, J. A., de Oliveira, C. L., Huber, D. A., & Lima, F. B. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.04.007 · Cited by 4
Flores‐Monroy, J., Lezama‐Martínez, D., Fonseca-Coronado, S., & Martínez-Aguilar, L. (2020) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320319900038 · Cited by 4
Borborema, M. E. D. A., de Lucena, T. M. C., & Silva, J. D. A. (2023) · Genetics and Molecular Biology · doi:10.1590/1415-4757-gmb-2022-0158 · Cited by 4
Sex and Gender Differences in Nephrology
Gallieni, M. A., Mezzina, N., Pinerolo, C., & Granata, A. R. M. (2011) · Springer eBooks · doi:10.1007/978-0-85729-832-4_7 · Cited by 4
Gao, H., Tanchico, D., Yallampalli, U., & Yallampalli, C. (2016) · Journal of Pregnancy · doi:10.1155/2016/4293431 · Cited by 4
Dexamethasone and cardiac potassium currents in the diabetic rat
Shimoni, Y. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706314 · Cited by 4
Choopani, S., & Nematbakhsh, M. (2025) · Hypertension Research · doi:10.1038/s41440-025-02400-y · Cited by 3
Li, C., Salisbury, R., & Ely, D. (2011) · ISRN Pathology · doi:10.5402/2011/367280 · Cited by 3
Silveira, L. C., da Silva, E. G., Azevedo, R. M., dos Anjos, L. R. B., Chagas, R. F., Alcântara, É. C., Santos, R. S., & Reis, Â. A. D. S. (2019) · Genetics and Molecular Research · doi:10.4238/gmr18378 · Cited by 3
Pre-natal programming of blood pressure and hypertension
Ojeda, N. B., Grigore, D., Hennington, B. S., & Alexander, B. T. (2008) · Cited by 3
Cocci, P., Mosconi, G., & Palermo, F. A. (2021) · Environments · doi:10.3390/environments8060058 · Cited by 3
Long Covid and Neurodegenerative DiseasePreprint
Chambers, P. W. (2023) · Preprints.org · doi:10.20944/preprints202302.0027.v2 · Cited by 2
Karjalainen, A. H. (2003) · Cited by 2
Singh, A. P., Singh, M., Kaur, T., Buttar, H. S., Ghuman, S. S., & Pathak, D. (2020) · Springer eBooks · doi:10.1007/978-3-030-47336-5_19 · Cited by 2
Non-Reproductive Effects of Estradiol: Hydromineral Homeostasis Control
Almeida‐Pereira, G., Elias, L. L. K., & Antunes‐Rodrigues, J. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.95348 · Cited by 2
Gangnus, T., Bartel, A., & Burckhardt, B. B. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03332-8 · Cited by 2
Gaspar, A. R., Andrade, B., Mosca, S. M. F. S., Ferreira‐Duarte, M., Teixeira, A., Cosme, D., Albino‐Teixeira, A., Ronchi, F. A., Leite, A. P. D. O., Casarini, D. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003345 · Cited by 2
O sistema renina-angiotensina em ovário
Costa, A. P. R., & Reis, A. M. (2000) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302000000400006 · Cited by 2
Characteristics of the Endothelium in Both Sexes
Costa, T. J. D., Echem, C., Colli, L. G., Akamine, E. H., Dantas, A. P., & de Carvalho, M. H. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812348-5.00006-4 · Cited by 2
Sex Differences in Vascular Function
Costa, T. J. D., & Tostes, R. C. (2023) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-39995-4_4 · Cited by 2
ROLE OF ANGIOTENSIN CONVERTING ENZYME 2 (ACE2) IN OBESITY-ASSOCIATED HYPERTENSION
Gupte, M. (2011) · UKnowledge (University of Kentucky) · Cited by 2
Schreuder, M. M., Colafella, K. M. M., Boersma, E. H., Brugts, J. J., van Lennep, J. E. R., & Versmissen, J. (2021) · Clinical and Translational Science · doi:10.1111/cts.13076 · Cited by 2
Estrogen and apoptosis in atherosclerosis
Barton, M., & Kockx, M. M. (2002) · International Congress Series · doi:10.1016/s0531-5131(01)00466-6 · Cited by 2
Ljungberg, L. U. (2009) · DiVA (Linkoping University) · Cited by 2
Angiotensin II type 1 receptors and oestrogen status: interaction or dissociation?
Zhuo, J. L. (2002) · Journal of Hypertension · doi:10.1097/00004872-200207000-00006 · Cited by 2
Modulation of blood pressure by estrogen: A modeling analysis
Layton, A. T. (2026) · Mathematical Biosciences · doi:10.1016/j.mbs.2025.109610 · Cited by 1
A 30-Year Journey Through Integrative Physiology Research and Education, Courtesy of Angiotensin II
Curtis, K. S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.785878 · Cited by 1
Dalpiaz, P. L. M., Lamas, A. Z., Caliman, I. F., Medeiros, A. R., Abreu, G. R., Moysés, M. R., Andrade, T., Alves, M. F. V., Carmona, A. K., & Bissoli, N. S. (2013) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2013005002472 · Cited by 1
Hypertension therapy with Equator according to the genotype of the estrogen receptor gene
Khabibulina, М., & Shamilov, М. (2023) · Vrach · doi:10.29296/25877305-2023-08-13 · Cited by 1
Hornung, E., Achanta, S., Moss, A., Schwaber, J. S., & Vadigepalli, R. (2024) · PLoS ONE · doi:10.1371/journal.pone.0313252 · Cited by 1
Dadam, F., Silva, G. V., Porcari, C. Y., Godino, A., Vivas, L., & Caeiro, X. E. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149740 · Cited by 1
Tian, L., Han, Z., Li, Y., & Jia, C. (2020) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001718 · Cited by 1
Androgen Excess in Women and the Respiratory System
Cardozo, L. L. Y., Rezq, S., Pruett, J. E., Garla, V. V., & Romero, D. G. (2021) · Physiology in health and disease · doi:10.1007/978-3-030-63549-7_14 · Cited by 1
Angiotensin-converting enzyme in cardiovascular function and dysfunction
Ljungberg, L. U. (2011) · DiVA (Linkoping University) · Cited by 1
Long Covid and Neurodegenerative DiseasePreprint
Chambers, P. W. (2023) · Preprints.org · doi:10.20944/preprints202302.0027.v1
Stadt, M. M., & Layton, A. T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.01.651663
“Researchers have reported that both ACE expression and activity are inhibited by estrogen in rodent models [26–29].”
Neidhardt, A. (2009) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-8097
Studies of pancreatic islet microcirculation and insulin secretion in normal and diabetic rats
Zhen, H. (2007) · Figshare
Arterial Tone in Chronic Renal Insufficiency
Kööbi, P. (2005) · Tampere University Institutional Repository (Tampere University)
Wang, Y. (2016) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2016.037
Rouleau, J. L., Adam, A. A., Lepage, Y., Gervais, N., Cugno, M., Ji, R., Woolf, C. J., Wang, H., Kohno, T., Brenner, G. J., et al. (2011)
Role of Sex Steroids in Hypertension
Reckelhoff, J. F., Yanes, L. L., Iliescu, R., Fortepiani, L. A., & Sartori‐Valinotti, J. C. (2007) · Elsevier eBooks · doi:10.1016/b978-0-323-03961-1.50037-4
Machado, C. D. S. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2017.tde-04012017-094931
The Skeletal Muscle RAS in Health and Disease
Woods, D. R. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6372-5_11
Khaksari, M., Hajmohammadi, M., & Sepehri, G. (2018) · Archives of Trauma Research · doi:10.4103/atr.atr_51_17
Asai, K., Murai, K., Shirakabe, A., Kamiya, M., Noma, S., Sato, N., Mizuno, K., & Shimizu, W. (2020) · Journal of Nippon Medical School · doi:10.1272/jnms.jnms.2021_88-303
Duprez, D. A. (2002) · Journal of Hypertension · doi:10.1097/00004872-200205000-00016
Dadam, F., Godino, A., Vivas, L., & Caeiro, X. E. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.15.464458
敏明, 中., 陽子, 飯., Oonuma, H., Kishida, S., 高野治人, 岩沢邦明, & 良三, 永. (2006) · 心臓 · doi:10.11281/shinzo1969.38.5_542
Monitoring and Assessment of Environmental Quality in Coastal Ecosystems
Gonçalves, S. C. (2021) · MDPI eBooks · doi:10.3390/books978-3-0365-2236-4
Charakterisierung östrogener Effekte von Genistein im Modell der langzeitovarektomierten Maus
Niepelt, A. (2014) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4724
Candesartan treatment preserves learning and working memory in female TgF344-AD ratsPreprint
Sinon, C. G., Carter, K., Ma, J., Bagchi, P., Zhang, X., Williams, P.-J. C., Dammer, E. B., Seyfried, N. T., García, P. S., Sutliff, R. L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.14.496112
Aissa, A. F. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2014.tde-02072024-102344
Roy, A.-S., Jolicoeur, M. E., Bérubé, L., Forcillo, J., Pacheco, C., Potter, B. J., Pelletier‐Galarneau, M., & Bouabdallaoui, N. (2026) · Heart Failure Reviews · doi:10.1007/s10741-026-10661-z · Cited by 1
Metadata
- Authors
- Gallagher, P. E., Li, P., Lenhart, J. R., Chappell, M. C., & Brosnihan, K. B.
- Affiliations
- Wake Forest University Health Sciences (US)
- Venue
- Hypertension
- Published
- 1999-01
- Volume
- 33
- Issue
- 1
- Pages
- 323-328
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2167128829
- Cited by
- 290
- References
- 54
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 9 · 2022: 8 · 2021: 14 · 2020: 12 · 2019: 14 · 2018: 11 · 2017: 9 · 2016: 7 · 2015: 4 · 2014: 9 · 2013: 9 · 2012: 7
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association (HL-56973)
- National Institutes of Health (HL‐56973)
- National Heart, Lung, and Blood Institute (R29HL056973, HL56973)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- estrogen, angiotensin-converting enzyme, estradiol, estrogen replacement therapy, angiotensin II, postmenopausal women, cardioprotection, renal cortex, renal medulla, lung, aorta, angiotensin-(1-7), bradykinin, ovariectomy
- MeSH terms
- Animals, Aorta, Estradiol, Female, Gene Expression Regulation, Humans, Kidney Cortex, Kidney Medulla, Peptidyl-Dipeptidase A, Lung, Muscle, Smooth, Vascular, Ovariectomy, RNA, Messenger, Transcription, Genetic, Estrogen Replacement Therapy, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
