The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Development of Hypertension in a Rat Model of Diet-Induced Obesity
Abstract
Abstract —Although obesity is a risk factor for hypertension, the relationship between these 2 conditions is not well understood. Therefore, we examined some parameters of hypertension and cardiovascular disease in a dietary model of obesity. Male Sprague-Dawley rats were provided either a control diet (C) or a diet containing 32% kcal as fat (similar to a Western diet) for 1, 3, or 10 weeks. Rats in the latter group diverged based on body weight gain into obesity-prone (OP) and obesity-resistant (OR) groups. Systolic blood pressure in OP rats was significantly higher after 10 weeks of the diet (149±4.8 mm Hg) compared with both OR and C groups (131±3.7 and 129±4.5 mm Hg, respectively). The aortic wall area of OP rats was significantly increased, indicating arterial hypertrophy, and a 2-fold increase in plasma renin activity was found in OP rats compared with OR and C rats. The lipid profile showed a significant increase in plasma and VLDL triglycerides of OP versus OR and C groups as early as 3 weeks on the diet. Plasma and LDL-cholesterol levels were increased in the OP group versus the OR and C groups after 3 weeks of the diet, but the difference was blunted after 10 weeks. Lipid peroxidation (thiobarbituric acid–reactive substances) in OP rats was increased 2-fold in LDL and 1.5-fold in aortic wall compared with OR rats, suggesting an increased oxidative stress in these animals. Periodic acid–Schiff staining of the kidney showed mesangial expansion and focal sclerosis that were more prominent in OP rats than in OR rats. The results suggest that hypercholesterolemia, but not hypertriglyceridemia, is linked to the diet; that hypertension and renin-angiotensin system activation are associated with obesity; and that lipid peroxidation and renal damage are the results of both factors.
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Cites
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,297
Markwell, M. A. K., Haas, S. M., Bieber, L. L., & Tolbert, N. E. (1978) · Analytical Biochemistry · doi:10.1016/0003-2697(78)90586-9 · Cited by 6,458
Assay of proteins in the presence of interfering materials
Bensadoun, A., & Weinstein, D. (1976) · Analytical Biochemistry · doi:10.1016/s0003-2697(76)80064-4 · Cited by 3,179
Watson, A. D., Berliner, J. A., Hama, S. Y., La Du, B. N., Faull, K. F., Fogelman, A. M., & Navab, M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118359 · Cited by 1,154
Separation of plasma lipoproteins by density-gradient ultracentrifugation
Redgrave, T. G., Roberts, D. C. K., & West, C. E. (1975) · Analytical Biochemistry · doi:10.1016/0003-2697(75)90488-1 · Cited by 1,107
Superoxide production by the mitochondrial respiratory chain
Turrens, J. F. (1997) · Bioscience Reports · doi:10.1023/a:1027374931887 · Cited by 903
Health Implications of Overweight and Obesity in the United States
VAN ITALLIE, T. B. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-103-6-983 · Cited by 899
Fogelman, A. M., Shechter, I., Seager, J., Hokom, M., Child, J. S., & Edwards, P. A. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.4.2214 · Cited by 849
Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension
Laursen, J. B., Rajagopalan, S., Galis, Z., Tarpey, M., Freeman, B. A., & Harrison, D. G. (1997) · Circulation · doi:10.1161/01.cir.95.3.588 · Cited by 823
The Relation of Adiposity to Blood Pressure and Development of Hypertension: The Framingham Study
KANNEL, W. B., BRAND, N., SKINNER, J. J., DAWBER, T. R., & MCNAMARA, P. M. (1967) · Annals of Internal Medicine · doi:10.7326/0003-4819-67-1-48 · Cited by 817
Cited by
Obesity, hypertension, and chronic kidney disease
Hall, J., Juncos, L., Wang, Z., Hall, M., do Carmo, J., & da Silva, A. (2014) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s39739 · Cited by 520
Cottam, D. R., Mattar, S. G., Barinas-Mitchell, E., Eid, G., Kuller, L., Kelley, D. E., & Schauer, P. R. (2004) · Obesity Surgery · doi:10.1381/096089204323093345 · Cited by 461
Mechanisms of Obesity-Associated Cardiovascular and Renal Disease
Hall, J. E., Crook, E. D., Jones, D. W., Wofford, M. R., & Dubbert, P. M. (2002) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200209000-00003 · Cited by 373
Animal models of metabolic syndrome: a review
Wong, S. K., Chin, K.-Y., Suhaimi, F. H., Fairus, A., & Ima-Nirwana, S. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0123-9 · Cited by 371
Boustany, C. M., Bharadwaj, K., Daugherty, A., Brown, D. R., Randall, D. C., & Cassis, L. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00265.2004 · Cited by 337
Metadata
- Authors
- Dobrian, A. D., Davies, M. J., Prewitt, R. L., & Lauterio, T. J.
- Venue
- Hypertension
- Published
- 2000-04
- Volume
- 35
- Issue
- 4
- Pages
- 1009-1015
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2107272046
- Cited by
- 306
- References
- 44
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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