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Cited by 337

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension

Boustany, Carine M., Bharadwaj, Kalyani, Daugherty, Alan, Brown, David R., Randall, David C., Cassis, Lisa A.·2004·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.00265.2004
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Abstract

In obesity-related hypertension, activation of the renin-angiotensin system (RAS) has been reported despite marked fluid volume expansion. Adipose tissue expresses components of the RAS and is markedly expanded in obesity. This study evaluated changes in components of the adipose and systemic RAS in diet-induced obese hypertensive rats. RAS was quantified in adipose tissue and compared with primary sources for the circulating RAS. Male Sprague-Dawley rats were fed either a low-fat (LF; 11% kcal as fat) or moderately high-fat (32% kcal as fat) diet for 11 wk. After 8 wk, rats fed the moderately high-fat diet segregated into obesity-prone (OP) and obesity-resistant (OR) groups based on their body weight gain (body weight: OR, 566 ± 10; OP, 702 ± 20 g; P < 0.05). Mean arterial blood pressure was increased in OP rats (LF: 97 ± 2; OR: 97 ± 2; OP: 105 ± 1 mmHg; P < 0.05). Quantification of mRNA expression by real-time PCR demonstrated a selective increase (2-fold) in angiotensinogen gene expression in retroperitoneal adipose tissue from OP vs. OR and LF rats. Similarly, plasma angiotensinogen concentration was increased in OP rats (LF: 390 ± 48; OR: 355 ± 24; OP: 530 ± 22 ng/ml; P < 0.05). In contrast, other components of the RAS were not altered in OP rats. Marked increases in the plasma concentrations of angiotensin peptides were observed in OP rats (angiotensin II: LF: 95 ± 31; OR: 59 ± 20; OP: 295 ± 118 pg/ml; P < 0.05). These results demonstrate increased activity of the adipose and systemic RAS in obesity-related hypertension.

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Metadata

Authors
Boustany, C. M., Bharadwaj, K., Daugherty, A., Brown, D. R., Randall, D. C., & Cassis, L. A.
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2004-10
Volume
287
Issue
4
Pages
R943-R949
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.00265.2004
OpenAlex
W2091296420
Cited by
337
References
43
FWCI
8.47
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension. https://app.cochat.ai/papers/10.1152/ajpregu.00265.2004
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Boustany, C. M., Bharadwaj, K., Daugherty, A., Brown, D. R., Randall, D. C., & Cassis, L. A. (2004). Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.00265.2004

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.