Cited by 475Renin-Angiotensin System StudiesAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

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Physiology and Pathophysiology of the Adipose Tissue Renin-Angiotensin System

Engeli, Stefan, Negrel, Raymond, Sharma, Arya M.·2000·Hypertension

DOI 10.1161/01.hyp.35.6.1270

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Abstract

Abstract—The renin-angiotensin system has long been recognized as an important regulator of systemic blood pressure and renal electrolyte homeostasis, and local renin-angiotensin systems have also been implicated in pathological changes of organ structure and function by modulation of gene expression, growth, fibrosis, and inflammatory response. Recently, substantial data have been accumulated in support of the notion that adipose tissue, besides other endocrine functions, also hosts a local renin-angiotensin system. In the first part of this review, we describe the components of the adipose tissue renin-angiotensin system in human and rodent animal models with respect to regulation of angiotensinogen expression and secretion, formation of angiotensin peptides, and the existence of angiotensin II receptors. In the second part, we describe the role of the adipose tissue renin-angiotensin system in the process of adipogenic differentiation and in the regulation of body weight. We also detail the differential regulation of the adipose tissue renin-angiotensin system in obesity and hypertension and thereby also speculate on its possible role in the development of obesity-associated hypertension. Although some findings on the adipose tissue renin-angiotensin system appear to be confusing, its involvement in the physiology and pathophysiology of adipose tissue has been confirmed by several functional studies. Nevertheless, future studies with more carefully described phenotypes are necessary to conclude whether obesity (by stimulation of adipogenic differentiation) and hypertension are associated with changes of renin-angiotensin system activity in adipose tissue. If so, the physiological relevance of this system in animal models and humans may warrant further interest.

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Authors: Engeli, S., Negrel, R., & Sharma, A. M.
Affiliations: Centre National de la Recherche Scientifique (FR)
From the Department of Internal Medicine, Division of Endocrinology and Nephrology, Benjamin Franklin Clinic, Free University of Berlin (Germany) (S.E., A.M.S.), and the Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre de Biochimie, Faculté des Sciences, Université de Nice-Sophia Antipolis, Parc Valrose, Nice Cedex, France (R.N.).
ORCID: Engeli, Stefan
Sharma, Arya M.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2000-06
Volume: 35
Issue: 6
Pages: 1270-1277
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/01.hyp.35.6.1270
OpenAlex: W2104491672
Cited by: 475
References: 117
Citations by year: 2026: 7 · 2025: 6 · 2024: 3 · 2023: 10 · 2022: 13 · 2021: 13 · 2020: 14 · 2019: 9 · 2018: 18 · 2017: 17 · 2016: 8 · 2015: 18 · 2014: 13 · 2013: 27 · 2012: 24
FWCI: 3.61
Type: journal article
Language: en
Open access: closed
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: local renin-angiotensin system, angiotensin II receptor, angiotensin peptides, adipogenesis, body weight regulation, obesity, obesity-related hypertension, adipose tissue physiology
MeSH terms: Adipose Tissue, Humans, Hypertension, Obesity, Reference Values, Renin-Angiotensin System

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Physiology and Pathophysiology of the Adipose Tissue Renin-Angiotensin System

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