Cited by 475Renin-Angiotensin System StudiesAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

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Physiology and Pathophysiology of the Adipose Tissue Renin-Angiotensin System

Engeli, Stefan, Negrel, Raymond, Sharma, Arya M.·2000·Hypertension

DOI 10.1161/01.hyp.35.6.1270

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Abstract

Abstract—The renin-angiotensin system has long been recognized as an important regulator of systemic blood pressure and renal electrolyte homeostasis, and local renin-angiotensin systems have also been implicated in pathological changes of organ structure and function by modulation of gene expression, growth, fibrosis, and inflammatory response. Recently, substantial data have been accumulated in support of the notion that adipose tissue, besides other endocrine functions, also hosts a local renin-angiotensin system. In the first part of this review, we describe the components of the adipose tissue renin-angiotensin system in human and rodent animal models with respect to regulation of angiotensinogen expression and secretion, formation of angiotensin peptides, and the existence of angiotensin II receptors. In the second part, we describe the role of the adipose tissue renin-angiotensin system in the process of adipogenic differentiation and in the regulation of body weight. We also detail the differential regulation of the adipose tissue renin-angiotensin system in obesity and hypertension and thereby also speculate on its possible role in the development of obesity-associated hypertension. Although some findings on the adipose tissue renin-angiotensin system appear to be confusing, its involvement in the physiology and pathophysiology of adipose tissue has been confirmed by several functional studies. Nevertheless, future studies with more carefully described phenotypes are necessary to conclude whether obesity (by stimulation of adipogenic differentiation) and hypertension are associated with changes of renin-angiotensin system activity in adipose tissue. If so, the physiological relevance of this system in animal models and humans may warrant further interest.

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(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663
Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction: Results of the Survival and Ventricular Enlargement Trial
Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911
Understanding Adipocyte Differentiation
Gregoire, F. M., Smas, C. M., & Sul, H. S. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.3.783 · Cited by 2,406
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
Forman, B. M., Chen, J., & Evans, R. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4312 · Cited by 2,116
Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial
Hansson, L., Lindholm, L. H., NISKANEN, L. K., Lanke, J., Hedner, T., Niklason, A., LUOMANMÄKI, K., Dahlöf, B., Fairé, U. D., Mörlin, C., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05012-0 · Cited by 1,991
Molecular basis of human hypertension: Role of angiotensinogen
Jeunemaı̂tre, X., Soubrier, F., Kotelevtsev, Y. V., Lifton, R. P., Williams, C. S., Charru, A., Hunt, S. C., Hopkins, P. N., Williams, R. R., Lalouel, J.-M., et al. (1992) · Cell · doi:10.1016/0092-8674(92)90275-h · Cited by 1,850
Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660
Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE)
Pitt, B., Segal, R., Martínez, F. A., Meurers, G., Cowley, A. J., Thomas, I., DEEDWANIA, P. C., Ney, D. E., Snavely, D. B., & Chang, P. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01187-2 · Cited by 1,660
Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
Lönnqvist, F., Arner, P., Nordfors, L., & Schalling, M. (1995) · Nature Medicine · doi:10.1038/nm0995-950 · Cited by 708
The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.
Nakajima, M., Hutchinson, H. G., Fujinaga, M., Hayashida, W., Morishita, R., Zhang, L., Horiuchi, M., Pratt, R. E., & Dzau, V. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10663 · Cited by 679

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10.1161/circ.87.6.8389259 · DOI
10.1161/hyp.31.6.1324 · DOI
10.1161/res.62.6.3383369 · DOI
Turban S, Hainault I, André J, Quignard-Boulangé A, Guerre-Millo M. Differential regulation of leptin and AGT secretion in rat adipose cells. Eating Weight Disord. 1999;4:34. Abstract.
10.1161/hyp.29.6.1240 · DOI
10.1161/hyp.27.3.760 · DOI
10.1161/hyp.30.2.209 · DOI
Richelsen B. Prostaglandins in adipose tissue. Dan Med Bull. 1991;38:228–244.
Mallow H, Trindl A, Löffler G. Production of angiotensin II receptors type 1 (AT1) and type 2 (AT2) during the differentiation of 3T3–L1 preadipocytes in culture. Eating Weight Disord. 1999;4:41. Abstract.
10.1161/hyp.33.1.340 · DOI
10.1161/hyp.28.6.1123 · DOI
10.1161/hyp.27.6.1216 · DOI
10.1161/hyp.30.4.859 · DOI
10.1161/circ.92.5.1089 · DOI
10.1161/hyp.28.6.1047 · DOI
Hainault I, Oppert JM, Basdevant A, Coussieu C, Guy-Grand B, Quignard-Boulangé A. Evidence of AGT and TNF-α secretion by human adipocytes from obese patients. Eating Weight Disord. 1999;4:31. Abstract.
Tamura K, Umemura S, Yamakawa T, Nyui N, Hibi K, Watanabe Y, Ishigami T, Yabana M, Tanaka SI, Sekihara H, Murakami K, Ishii M. Modulation of tissue AGT gene expression in genetically obese hypertensive rats. Am J Physiol. 1997;272:R1704–R1711.
Massiéra F, Murakami K, Fukamizu A, Negrel R, Ailhaud G, Teboul M. Effects of high fat diet on adiposity in AGT deficient and wild type mice. Eating Weight Disord. 1999;4:41. Abstract.

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References
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References
(2005) · Wiley eBooks · doi:10.1002/9780470774663.refs
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Lefranc, C. (2020) · theses.fr (ABES) · doi:10.70675/63bffb80z502cz4bdcz9729ze61518233589
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Ribeiro, M. V. G., Ferreira, A. R. O., Barbosa, L. F., Lopes, G. K. G., Piovan, S., Saavedra, L. P. J., Raposo, S. R., Gomes, R. M., Malta, A., Almeida, D. L., et al. (2026) · Nutrition Research · doi:10.1016/j.nutres.2026.03.013
Effets bénéfiques de la finerénone, antagoniste du récepteur minéralocorticoïde, dans les conséquences cardiovasculaires d'un syndrome métabolique, chez des souris en conditions de post-ménopause ou après amaigrissement de souris mâles obèses.
Pieronne-Deperrois, M. (2022) · theses.fr (ABES) · doi:10.70675/71ef46cfz0230z4862za32aze1072fe4be66
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Authors: Engeli, S., Negrel, R., & Sharma, A. M.
Affiliations: Centre National de la Recherche Scientifique (FR)
From the Department of Internal Medicine, Division of Endocrinology and Nephrology, Benjamin Franklin Clinic, Free University of Berlin (Germany) (S.E., A.M.S.), and the Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre de Biochimie, Faculté des Sciences, Université de Nice-Sophia Antipolis, Parc Valrose, Nice Cedex, France (R.N.).
ORCID: Engeli, Stefan
Sharma, Arya M.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2000-06
Volume: 35
Issue: 6
Pages: 1270-1277
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/01.hyp.35.6.1270
OpenAlex: W2104491672
Cited by: 475
References: 117
Citations by year: 2026: 7 · 2025: 6 · 2024: 3 · 2023: 10 · 2022: 13 · 2021: 13 · 2020: 14 · 2019: 9 · 2018: 18 · 2017: 17 · 2016: 8 · 2015: 18 · 2014: 13 · 2013: 27 · 2012: 24
FWCI: 3.61
Type: journal article
Language: en
Open access: closed
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: local renin-angiotensin system, angiotensin II receptor, angiotensin peptides, adipogenesis, body weight regulation, obesity, obesity-related hypertension, adipose tissue physiology
MeSH terms: Adipose Tissue, Humans, Hypertension, Obesity, Reference Values, Renin-Angiotensin System

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Physiology and Pathophysiology of the Adipose Tissue Renin-Angiotensin System

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