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Cited by 352

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Relationship between plasma norepinephrine and sympathetic neural activity.

Open access
Goldstein, D S, McCarty, R, Polinsky, R J, Kopin, I J·1983·Hypertension

Abstract

For circulating norepinephrine (NE) to reflect sympathetic activity validly, plasma NE should show an intensity-dependent increase during sympathetic stimulation and decrease during sympathetic inhibition, and circulating NE should correlate with more directly obtained measures of sympathetic activity. Review of published evidence indicates that NE in peripheral plasma satisfies these criteria. However, models used to explain the relationship between circulating NE and sympathetic activity must take into account processes intervening between the synaptic cleft and free NE in the circulation and, since sympathetic outflow is regionalized, the contributions of specific vascular beds to circulating NE. In this report a model is presented where removal processes for NE are viewed as acting in series to produce a gradient in NE concentrations from synapse to plasma, and where the relative contributions of specific vascular beds are calculated from the arteriovenous difference in plasma NE across those beds and the percentage of cardiac output distributed to them. In general, venous plasma NE provides a useful estimation of average sympathetic outflow.

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Crossref · 10.1161/01.hyp.5.4.552

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Metadata

Authors
Goldstein, D. S., McCarty, R., Polinsky, R. J., & Kopin, I. J.
Venue
Hypertension
Published
1983-07
Volume
5
Issue
4
Pages
552-559
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
OpenAlex
W1986873747
Cited by
352
References
66
FWCI
14.06
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Relationship between plasma norepinephrine and sympathetic neural activity. https://app.cochat.ai/papers/10.1161/01.hyp.5.4.552
The paper
Goldstein, D. S., McCarty, R., Polinsky, R. J., & Kopin, I. J. (1983). Relationship between plasma norepinephrine and sympathetic neural activity. Hypertension. https://doi.org/10.1161/01.hyp.5.4.552

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.