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Cited by 552

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Interactions between ANG II, sympathetic nervous system, and baroreceptor reflexes in regulation of blood pressure

Reid, I. A.·1992·American Journal of Physiology-Endocrinology and Metabolism

Abstract

The renin-angiotensin system plays an important role in the regulation of arterial blood pressure and in the development of some forms of clinical and experimental hypertension. It is an important blood pressure control system in its own right but also interacts extensively with other blood pressure control systems, including the sympathetic nervous system and the baroreceptor reflexes. Angiotensin (ANG) II exerts several actions on the sympathetic nervous system. These include a central action to increase sympathetic outflow, stimulatory effects on sympathetic ganglia and the adrenal medulla, and actions at sympathetic nerve endings that serve to facilitate sympathetic neurotransmission. ANG II also interacts with baroreceptor reflexes. For example, it acts centrally to modulate the baroreflex control of heart rate, and this accounts for its ability to increase blood pressure without causing a reflex bradycardia. The physiological significance of these actions of ANG II is not fully understood. Most evidence indicates that the actions of ANG to enhance sympathetic activity do not contribute significantly to the pressor response to exogenous ANG II. On the other hand, there is considerable evidence that the actions of endogenous ANG II on the sympathetic nervous system enhance the cardiovascular responses elicited by activation of the sympathetic nervous system.

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Crossref · 10.1152/ajpendo.1992.262.6.e763

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Metadata

Authors
Reid, I. A.
Venue
American Journal of Physiology-Endocrinology and Metabolism
Published
1992-06-01
Volume
262
Issue
6
Pages
E763-E778
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
OpenAlex
W143205812
Cited by
552
References
65
FWCI
10.17
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Interactions between ANG II, sympathetic nervous system, and baroreceptor reflexes in regulation of blood pressure. https://app.cochat.ai/papers/10.1152/ajpendo.1992.262.6.e763
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Reid, I. A. (1992). Interactions between ANG II, sympathetic nervous system, and baroreceptor reflexes in regulation of blood pressure. American Journal of Physiology-Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.1992.262.6.e763

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