The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Early Signals in Cardiac Development
Open accessAbstract
The heart is the first organ to form during embryogenesis and its circulatory function is critical from early on for the viability of the mammalian embryo. Developmental abnormalities of the heart have also been widely recognized as the underlying cause of many congenital heart malformations. Hence, the developmental mechanisms that orchestrate the formation and morphogenesis of this organ have received much attention among classical and molecular embryologists. Due to the evolutionary conservation of many of these processes, major insights have been gained from the studies of a number of vertebrate and invertebrate models, including mouse, chick, amphibians, zebrafish, and Drosophila . In all of these systems, the heart precursors are generated within bilateral fields in the lateral mesoderm and then converge toward the midline to form a beating linear heart tube. The specification of heart precursors is a result of multiple tissue and cell-cell interactions that involve temporally and spatially integrated programs of inductive signaling events. In the present review, we focus on the molecular and developmental functions of signaling processes during early cardiogenesis that have been defined in both vertebrate and invertebrate models. We discuss the current knowledge on the mechanisms through which signals induce the expression of cardiogenic transcription factors and the relationships between signaling pathways and transcriptional regulators that cooperate to control cardiac induction and the formation of a linear heart tube.
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Cites
Congenital Heart Disease Caused by Mutations in the Transcription Factor NKX2-5
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GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.
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Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice
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TBX1 Is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome
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Notch Signaling: From the Outside In
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Cited by
Gene regulatory networks for development
Levine, M., & Davidson, E. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408031102 · Cited by 796
A Transcription Factor Collective Defines Cardiac Cell Fate and Reflects Lineage History
Junion, G., Spivakov, M., Girardot, C., Braun, M., Gustafson, E. H., Birney, E., & Furlong, E. E. M. (2012) · Cell · doi:10.1016/j.cell.2012.01.030 · Cited by 257
Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails.
Fu, Y., Huang, C., Xu, X., Gu, H., Ye, Y., Jiang, C., Qiu, Z., & Xie, X. (2015) · Cell Research · doi:10.1038/cr.2015.99 · Cited by 248
Metadata
- Authors
- Zaffran, S., & Frasch, M.
- Venue
- Circulation Research
- Published
- 2002-09-20
- Volume
- 91
- Issue
- 6
- Pages
- 457-469
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2154070829
- Cited by
- 306
- References
- 126
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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