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Sarcoplasmic Reticulum Ca 2+ and Heart Failure: Roles of Diastolic Leak and Ca 2+ Transport
Open accessAbstract
eart failure (HF) is a leading cause of death and enormous effort has focused at understanding the molecular and cellular mechanisms of the decreased cardiac contractility.While changes of other components contribute, it is generally agreed that much of the contractile deficit is due to reduced myocyte Ca 2ϩ transients.1,2 Alterations in Ca 2ϩ current (I Ca ) and action potential characteristics are also seen in HF, but a central factor limiting Ca 2ϩ transient amplitude is a decrease of sarcoplasmic reticulum (SR) Ca 2ϩ content.3-6 HF is extremely complex, but it is easy to appreciate how reduced SR Ca 2ϩ content would reduce SR Ca 2ϩ release, myofilament activation, and contractility.Despite agreement that SR Ca 2ϩ content is reduced in HF, controversy exists about why SR content is low. Limitations of the RyR Hyperphosphorylation HypothesisThis is an important hypothesis but requires further testing.Some published data are inconsistent with critical aspects of
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Cited by
Calcium Cycling and Signaling in Cardiac Myocytes
Bers, D. M. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100455 · Cited by 1,302
Self-citationter Keurs, H. E. D. J., & Boyden, P. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00011.2006 · Cited by 356
Maier, L. S., & Bers, D. M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.11.005 · Cited by 330
Self-citationKrishnan, B., Massilamany, C., Basavalingappa, R. H., Gangaplara, A., Rajasekaran, R. A., Afzal, M. Z., Khalilzad-Sharghi, V., Zhou, Y., Riethoven, J.-J., Nandi, S. S., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701090 · Cited by 17
Engineering the cardiac tissue microenvironment
Ronan, G., Bahcecioglu, G., Aliyev, N., & Zorlutuna, P. (2024) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ad0ea7 · Cited by 4
Metadata
- Authors
- Bers, D. M., Eisner, D. A., & Valdivia, H. H.
- Venue
- Circulation Research
- Published
- 2003-09-19
- Volume
- 93
- Issue
- 6
- Pages
- 487-490
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2170220392
- Cited by
- 282
- References
- 0
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bers, D. M., Eisner, D. A., & Valdivia, H. H. (2003). Sarcoplasmic Reticulum Ca 2+ and Heart Failure: Roles of Diastolic Leak and Ca 2+ Transport. Circulation Research. https://doi.org/10.1161/01.res.0000091871.54907.6b
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