The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Giant Protein Titin: A Major Player in Myocardial Mechanics, Signaling, and Disease
Open accessAbstract
The sarcomere contains, in addition to thin and thick filaments, a filament composed of the giant protein titin (also known as connectin). Titin molecules anchor in the Z-disc and extend to the M-line region of the sarcomere. The majority of titin’s I-band region functions as a molecular spring. This spring maintains the precise structural arrangement of thick and thin filaments, and gives rise to passive muscle stiffness; an important determinant of diastolic filling. Earlier work on titin has been reviewed before. In this study, our main focus is on recent findings vis-à-vis titin’s molecular spring segments in cardiac titins, including the discovery of fetal cardiac isoforms with novel spring elements. We also discuss new insights regarding the role of titin as a biomechanical sensor and signaling molecule. We will end with focusing on the rapidly growing knowledge regarding titinopathies.
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Cites
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521
Knöll, R., Hoshijima, M., Hoffman, H. M., Person, V., Lorenzen-Schmidt, I., Bang, M.-L., Hayashi, T., Shiga, N., Yasukawa, H., Schaper, W., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01226-6 · Cited by 786
Differential expression of cardiac titin isoforms and modulation of cellular stiffness
Cazorla, O., Freiburg, A., Helmes, M., Centner, T., McNabb, M., Wu, Y., Trombitás, K., Labeit, S., & Granzier, H. (2000) · Circulation Research · doi:10.1161/01.res.86.1.59 · Cited by 418
Self-citationAlterations in the determinants of diastolic suction during pacing tachycardia
Bell, S. P., Nyland, L., Tischler, M. D., McNabb, M., Granzier, H., & LeWinter, M. M. (2000) · Circulation Research · doi:10.1161/01.res.87.3.235 · Cited by 190
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Cited by
Truncations of titin causing dilated cardiomyopathy
Herman, D. S., Lam, L., Taylor, M. R. G., Wang, L., Teekakirikul, P., Christodoulou, D., Conner, L., DePalma, S. R., McDonough, B., Sparks, E., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110186 · Cited by 1,485
Zile, M. R., Baicu, C. F., S. Ikonomidis, J., Stroud, R. E., Nietert, P. J., Bradshaw, A. D., Slater, R., Palmer, B. M., Van Buren, P., Meyer, M., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.013215 · Cited by 681
Nagueh, S. F., Shah, G., Wu, Y., Torre-Amione, G., King, N. M. P., Lahmers, S., Witt, C. C., Becker, K., Labeit, S., & Granzier, H. L. (2004) · Circulation · doi:10.1161/01.cir.0000135591.37759.af · Cited by 486
Self-citationPrado, L. G., Makarenko, I., Andresen, C., Krüger, M., Opitz, C. A., & Linke, W. A. (2005) · The Journal of General Physiology · doi:10.1085/jgp.200509364 · Cited by 363
Mechanisms of Altered Ca 2+ Handling in Heart Failure
Luo, M., & Anderson, M. E. (2013) · Circulation Research · doi:10.1161/circresaha.113.301651 · Cited by 357
Metadata
- Authors
- Granzier, H. L., & Labeit, S.
- Venue
- Circulation Research
- Published
- 2004-02-20
- Volume
- 94
- Issue
- 3
- Pages
- 284-295
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2141336992
- Cited by
- 649
- References
- 4
- FWCI
- 27.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
