The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Angiogenesis Inhibitor, TNP-470, Prevents Diet-Induced and Genetic Obesity in Mice
Open accessAbstract
Adipose tissue growth has been proposed to involve recruitment of new blood vessels. Here, we test the hypothesis that delivery of an angiogenesis inhibitor in mice may prevent diet-induced obesity, the most common type of obesity in humans. We show that systemic administration of a selective angiogenesis inhibitor, TNP-470 (AGM-1470), prevents obesity in high caloric diet-fed wt mice as well as in genetically leptin-deficient ob/ob mice. Inhibition of obesity in mice by TNP-470 involves a reduction of vascularity in the adipose tissue. This therapeutic strategy appears to selectively affect the growth of adipose tissue as measured by the ratio between total fat and lean body mass. Interestingly, the treatment with TNP-470 results in decreased serum levels of low-density lipoprotein cholesterol. Furthermore, insulin levels are reduced, which indicates increased insulin sensitivity, suggesting that angiogenesis inhibitors may prevent the development of type II diabetes. Our findings suggest that similarly to growth and organogenesis in other tissues, adipose tissue growth is dependent on angiogenesis. Our observations may have conceptual implications for the prevention of obesity and related disorders.
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“Chemical angiogenic inhibitors such as angiostatin, endostatin, and thalidomide as well as the VEGFR2-blocking antibody TNP-470, have been tested in diet-induced obese mice or genetically obese ob/ob mice and shown to significantly reduce body weight and fat pad mass (88,89).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [89]
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Cites
Snedecor, G. W., Cochran, W. G., & STOUT, B. B. (1939) · Soil Science · doi:10.1097/00010694-193902000-00006 · Cited by 19,423
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Towards a molecular understanding of adaptive thermogenesis
Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630
Biological Action of Leptin as an Angiogenic Factor
Sierra-Honigmann, M. R., Nath, A. K., Murakami, C., García‐Cardeña, G., Papapetropoulos, A., Sessa, W. C., Madge, L. A., Schechner, J. S., Schwabb, M. B., Polverini, P. J., et al. (1998) · Science · doi:10.1126/science.281.5383.1683 · Cited by 1,385
Adipose tissue mass can be regulated through the vasculature
Rupnick, M. A., Panigrahy, D., Zhang, C.-Y., Dallabrida, S. M., Lowell, B. B., Langer, R., & Folkman, M. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162349799 · Cited by 845
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- 10.1161/res.83.10.1059 · DOI
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Cornelius, P. K., Mayes, B. A., Dannenberg, A. J., Dufour, P. J., Little, S., Guzior, D. V., Petersen, J. S., Shanahan, J. M., & Carver, B. J. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1751681
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Caër, C. (2016) · theses.fr (ABES) · doi:10.70675/65eca5dczaa63z4e9az82dbzb223bfe8ef82 · Cited by 1
Magalon, J. (2018) · doi:10.70675/917579acze581z4bfbzb10czc6d5c3150e9d
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Morin, S. O. (2017) · theses.fr (ABES) · doi:10.70675/cb01635fz2f63z43e2zad0cz210485c4c5cf
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Casteras, S. (2012) · theses.fr (ABES) · doi:10.70675/7b0400e0z9e49z4df6za2c1z0c19ce63d0ca
An emerging role for eosinophils as pro-angiogenic drivers of adipose tissue beiging
Valentini, T. J., Spek, A. C., & Quinlan, K. G. R. (2026) · Clinical Science · doi:10.1042/cs20250051
Chaurasiya, V., Pham, D. D., & Olkkonen, V. M. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1957205
Is the Adipose Tissue Vascular System a Therapeutic Target in the Era of Precision Medicine?
Silva, D., Sousa, D., Magalhães, C. C., & Matafome, P. N. (2026) · Medicinal Research Reviews · doi:10.1002/med.70121
Quantitative Methods to Study Adipose Angiogenesis
Lim, S., Honek, J., Cao, Z., Seki, T., Xue, Y., & Cao, Y. (2012) · Springer eBooks · doi:10.1007/978-94-007-4581-0_5
Self-citationSirois‐Gagnon, D. (2011) · Constellation (Université du Québec à Chicoutimi) · doi:10.1522/030175066
Vascular Targeting of Adipose Tissue
Salameh, A., & Kolonin, M. G. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6819-6_15
Metadata
- Authors
- Bråkenhielm, E., Cao, R., Gao, B., Angelin, B., Cannon, B., Parini, P., & Cao, Y.
- Affiliations
- From the Microbiology and Tumor Biology Center (E.B., R.C., Y.C.), Karolinska Institutet, Stockholm, Sweden; The Wenner-Gren Institute (B.G., B.C.), The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden; and Metabolism Unit (B.A., P.P.), Center for Metabolism and Endocrinology, Department of Medicine and Molecular Nutrition, Center for Nutrition and Toxicology, Novum, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden.
- Stockholm University (SE)
- Venue
- Circulation Research
- Published
- 2004-06-25
- Volume
- 94
- Issue
- 12
- Pages
- 1579-1588
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2098387318
- Cited by
- 326
- References
- 38
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 12 · 2023: 13 · 2022: 10 · 2021: 7 · 2020: 10 · 2019: 16 · 2018: 18 · 2017: 22 · 2016: 12 · 2015: 11 · 2014: 22 · 2013: 35 · 2012: 20
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancerfonden
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- TNP-470, angiogenesis inhibitors, diet-induced obesity, genetic obesity, ob/ob mice, leptin deficiency, adipose tissue expansion, LDL cholesterol, insulin sensitivity, type 2 diabetes prevention
- MeSH terms
- O-(Chloroacetylcarbamoyl)fumagillol, Adipose Tissue, Animals, Body Composition, Cattle, Cornea, Cyclohexanes, Dietary Fats, Drug Evaluation, Preclinical, Endothelium, Vascular, Insulin Resistance, Lipids, Male, Mice, Inbred C57BL, Mice, Obese, Obesity, Oxygen Consumption, Sesquiterpenes, Neovascularization, Physiologic, Anti-Obesity Agents, Angiogenesis Inhibitors, 3T3-L1 Cells, Endothelial Cells, Carbohydrate Metabolism, Lipid Metabolism, Mice
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