Adipose tissue mass can be regulated through the vasculature
Open accessAbstract
Tumor growth is angiogenesis dependent. We hypothesized that nonneoplastic tissue growth also depends on neovascularization. We chose adipose tissue as an experimental system because of its remodeling capacity. Mice from different obesity models received anti-angiogenic agents. Treatment resulted in dose-dependent, reversible weight reduction and adipose tissue loss. Marked vascular remodeling was evident in adipose tissue sections, which revealed decreased endothelial proliferation and increased apoptosis in treated mice compared with controls. Continuous treatment maintained mice near normal body weights for age without adverse effects. Metabolic adaptations in food intake, metabolic rate, and energy substrate utilization were associated with anti-angiogenic weight loss. We conclude that adipose tissue mass is sensitive to angiogenesis inhibitors and can be regulated by its vasculature.
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Chemical angiogenic inhibitors such as angiostatin, endostatin, thalidomide, and VEGFR2-blocking antibody TNP-470 reduce body weight and fat pad mass in diet-induced obese or genetically obese ob/ob mice.
“Chemical angiogenic inhibitors such as angiostatin, endostatin, and thalidomide as well as the VEGFR2-blocking antibody TNP-470, have been tested in diet-induced obese mice or genetically obese ob/ob mice and shown to significantly reduce body weight and fat pad mass (88,89).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [88]
Effective development of the vascular supply through angiogenesis is a rate-limiting step in adipose tissue expansion.
“Effective development of the vascular supply through angiogenesis is therefore a rate-limiting step in AT expansion (67).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [67]
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- Authors
- Rupnick, M. A., Panigrahy, D., Zhang, C.-Y., Dallabrida, S. M., Lowell, B. B., Langer, R., & Folkman, M. J.
- Affiliations
- Brigham and Women's Hospital (US)
- Division of Cardiovascular Medicine, Brigham and Women's Hospital, Division of Surgical Research, Children's Hospital, and Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02115; and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-07-29
- Volume
- 99
- Issue
- 16
- Pages
- 10730-10735
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC125027
- OpenAlex
- W1999239339
- Cited by
- 845
- References
- 45
- Citations by year
- 2026: 13 · 2025: 5 · 2024: 21 · 2023: 22 · 2022: 27 · 2021: 19 · 2020: 29 · 2019: 27 · 2018: 35 · 2017: 39 · 2016: 31 · 2015: 34 · 2014: 49 · 2013: 65 · 2012: 47
- FWCI
- 16.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k08hl003698-05)
- National Heart, Lung, and Blood Institute (K08 HL03698)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- adipose tissue mass, angiogenesis, angiogenesis inhibitors, neovascularization, obesity, vascular remodeling, endothelial cell apoptosis, endothelial cell proliferation, weight loss, metabolic adaptation, dietary intake, energy substrate utilization
- MeSH terms
- O-(Chloroacetylcarbamoyl)fumagillol, Adipose Tissue, Animals, Antineoplastic Agents, Biphenyl Compounds, Body Composition, Body Weight, Collagen, Cyclohexanes, Disease Models, Animal, Energy Metabolism, Male, Mice, Inbred C57BL, Neovascularization, Pathologic, Obesity, Organic Chemicals, Peptide Fragments, Phenylbutyrates, Plasminogen, Sesquiterpenes, Thalidomide, Time Factors, Angiogenesis Inhibitors, Angiostatins, Endostatins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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