Cited by 845Adipose Tissue and MetabolismAngiogenesis and VEGF in CancerAdipokines, Inflammation, and Metabolic Diseases

Adipose tissue mass can be regulated through the vasculature

Open access
Rupnick, Maria A., Panigrahy, Dipak, Zhang, Chen-Yu, Dallabrida, Susan M., Lowell, Bradford B., Langer, Robert, Folkman, M. Judah·2002·Proceedings of the National Academy of Sciences

Abstract

Tumor growth is angiogenesis dependent. We hypothesized that nonneoplastic tissue growth also depends on neovascularization. We chose adipose tissue as an experimental system because of its remodeling capacity. Mice from different obesity models received anti-angiogenic agents. Treatment resulted in dose-dependent, reversible weight reduction and adipose tissue loss. Marked vascular remodeling was evident in adipose tissue sections, which revealed decreased endothelial proliferation and increased apoptosis in treated mice compared with controls. Continuous treatment maintained mice near normal body weights for age without adverse effects. Metabolic adaptations in food intake, metabolic rate, and energy substrate utilization were associated with anti-angiogenic weight loss. We conclude that adipose tissue mass is sensitive to angiogenesis inhibitors and can be regulated by its vasculature.

Integrity signals

Registry

Crossref · 10.1073/pnas.162349799

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Chemical angiogenic inhibitors such as angiostatin, endostatin, thalidomide, and VEGFR2-blocking antibody TNP-470 reduce body weight and fat pad mass in diet-induced obese or genetically obese ob/ob mice.

    “Chemical angiogenic inhibitors such as angiostatin, endostatin, and thalidomide as well as the VEGFR2-blocking antibody TNP-470, have been tested in diet-induced obese mice or genetically obese ob/ob mice and shown to significantly reduce body weight and fat pad mass (88,89).”
  • Effective development of the vascular supply through angiogenesis is a rate-limiting step in adipose tissue expansion.

    “Effective development of the vascular supply through angiogenesis is therefore a rate-limiting step in AT expansion (67).”

    From Adipose tissue remodeling and obesity (2011) · cites this paper as [67]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Rupnick, M. A., Panigrahy, D., Zhang, C.-Y., Dallabrida, S. M., Lowell, B. B., Langer, R., & Folkman, M. J.
Affiliations
  • Brigham and Women's Hospital (US)
  • Division of Cardiovascular Medicine, Brigham and Women's Hospital, Division of Surgical Research, Children's Hospital, and Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02115; and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
Venue
Proceedings of the National Academy of Sciences
Published
2002-07-29
Volume
99
Issue
16
Pages
10730-10735
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1999239339
Cited by
845
References
45
Citations by year
2026: 13 · 2025: 5 · 2024: 21 · 2023: 22 · 2022: 27 · 2021: 19 · 2020: 29 · 2019: 27 · 2018: 35 · 2017: 39 · 2016: 31 · 2015: 34 · 2014: 49 · 2013: 65 · 2012: 47
FWCI
16.35
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k08hl003698-05)
  • National Heart, Lung, and Blood Institute (K08 HL03698)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
adipose tissue mass, angiogenesis, angiogenesis inhibitors, neovascularization, obesity, vascular remodeling, endothelial cell apoptosis, endothelial cell proliferation, weight loss, metabolic adaptation, dietary intake, energy substrate utilization
MeSH terms
O-(Chloroacetylcarbamoyl)fumagillol, Adipose Tissue, Animals, Antineoplastic Agents, Biphenyl Compounds, Body Composition, Body Weight, Collagen, Cyclohexanes, Disease Models, Animal, Energy Metabolism, Male, Mice, Inbred C57BL, Neovascularization, Pathologic, Obesity, Organic Chemicals, Peptide Fragments, Phenylbutyrates, Plasminogen, Sesquiterpenes, Thalidomide, Time Factors, Angiogenesis Inhibitors, Angiostatins, Endostatins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review