The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases
Open accessAbstract
Cardiac myocytes have provided a key paradigm for the concept of the compartmentalized cAMP generation sensed by AKAP-anchored PKA. Phosphodiesterases (PDEs) provide the sole route for degrading cAMP in cells and are thus poised to regulate intracellular cAMP gradients. PDE3 and PDE4 represent the major cAMP degrading activities in rat ventriculocytes. By performing real-time imaging of cAMP in situ, we establish the hierarchy of these PDEs in controlling cAMP levels in basal conditions and on stimulation with a β-adrenergic receptor agonist. PDE4, rather than PDE3, appears to be responsible for modulating the amplitude and duration of the cAMP response to beta-agonists. PDE3 and PDE4 localize to distinct compartments and this may underpin their different functional roles. Our findings indicate the importance of distinctly localized PDE isoenzymes in determining compartmentalized cAMP signaling.
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Baillie, G. S., Sood, A., McPhee, I., Gall, I., Perry, S. J., Lefkowitz, R. J., & Houslay, M. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262787199 · Cited by 360
Self-citationRetractedBradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,556
Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms
Beavo, J. A. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.4.725 · Cited by 1,767
Cyclic nucleotide research — still expanding after half a century
Beavo, J. A., & Brunton, L. L. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm911 · Cited by 903
Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes
Zaccolo, M., & Pozzan, T. (2002) · Science · doi:10.1126/science.1069982 · Cited by 855
Self-citationWhat Is the Role of β-Adrenergic Signaling in Heart Failure?
Lohse, M. J., Engelhardt, S., & Eschenhagen, T. (2003) · Circulation Research · doi:10.1161/01.res.0000102042.83024.ca · Cited by 764
Self-citationHOUSLAY, M. D., & ADAMS, D. R. (2003) · Biochemical Journal · doi:10.1042/bj20021698 · Cited by 763
Self-citationAKAPs: from structure to function
Colledge, M., & Scott, J. D. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01558-5 · Cited by 611
mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
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Cited by
Fluorescent Proteins and Their Applications in Imaging Living Cells and Tissues
Chudakov, D. M., Matz, M. V., Lukyanov, S., & Lukyanov, K. A. (2010) · Physiological Reviews · doi:10.1152/physrev.00038.2009 · Cited by 1,375
Lugnier, C. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.07.003 · Cited by 870
Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions
Francis, S. H., Blount, M. A., & Corbin, J. D. (2011) · Physiological Reviews · doi:10.1152/physrev.00030.2010 · Cited by 639
Lehnart, S. E., Wehrens, X. H. T., Reiken, S., Warrier, S., Belevych, A. E., Harvey, R. D., Richter, W., Jin, S.-L. C., Conti, M., & Marks, A. R. (2005) · Cell · doi:10.1016/j.cell.2005.07.030 · Cited by 517
Organization and Ca2+Regulation of Adenylyl Cyclases in cAMP Microdomains
Willoughby, D., & Cooper, D. M. F. (2007) · Physiological Reviews · doi:10.1152/physrev.00049.2006 · Cited by 451
Metadata
- Authors
- Mongillo, M., McSorley, T., Evellin, S., Sood, A., Lissandron, V., Terrin, A., Huston, E., Hannawacker, A., Lohse, M. J., Pozzan, T., Houslay, M. D., & Zaccolo, M.
- Venue
- Circulation Research
- Published
- 2004-07-09
- Volume
- 95
- Issue
- 1
- Pages
- 67-75
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2122001651
- Cited by
- 384
- References
- 40
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases. https://app.cochat.ai/papers/10.1161/01.res.0000134629.84732.11
- The paper
- Mongillo, M., McSorley, T., Evellin, S., Sood, A., Lissandron, V., Terrin, A., Huston, E., Hannawacker, A., Lohse, M. J., Pozzan, T., Houslay, M. D., & Zaccolo, M. (2004). Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases. Circulation Research. https://doi.org/10.1161/01.res.0000134629.84732.11
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
