The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Proinflammatory Activation of Macrophages by Basic Calcium Phosphate Crystals via Protein Kinase C and MAP Kinase Pathways: A Vicious Cycle of Inflammation and Arterial Calcification?
Open accessAbstract
Basic calcium phosphate (BCP) crystal deposition underlies the development of arterial calcification. Inflammatory macrophages colocalize with BCP deposits in developing atherosclerotic lesions and in vitro can promote calcification through the release of TNF alpha. Here we have investigated whether BCP crystals can elicit a proinflammatory response from monocyte-macrophages. BCP microcrystals were internalized into vacuoles of human monocyte-derived macrophages in vitro. This was associated with secretion of proinflammatory cytokines (TNFα, IL-1β and IL-8) capable of activating cultured endothelial cells and promoting capture of flowing leukocytes under shear flow. Critical roles for PKC, ERK1/2, JNK, but not p38 intracellular signaling pathways were identified in the secretion of TNF alpha, with activation of ERK1/2 but not JNK being dependent on upstream activation of PKC. Using confocal microscopy and adenoviral transfection approaches, we determined a specific role for the PKC-alpha isozyme. The response of macrophages to BCP crystals suggests that pathological calcification is not merely a passive consequence of chronic inflammatory disease but may lead to a positive feed-back loop of calcification and inflammation driving disease progression.
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
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Prediction of coronary events with electron beam computed tomography
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Philippidis, P., Mason, J. C., Evans, B. J., Nadra, I., Taylor, K. M., Haskard, D. O., & Landis, R. C. (2004) · Circulation Research · doi:10.1161/01.res.0000109414.78907.f9 · Cited by 476
Self-citationGreaves, D. R., & Gordon, S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.r400011-jlr200 · Cited by 211
Cited by
Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
Lacolley, P., Regnault, V., Segers, P., & Laurent, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00003.2017 · Cited by 734
Aikawa, E., Nahrendorf, M., Figueiredo, J.-L., Swirski, F. K., Shtatland, T., Kohler, R. H., Jaffer, F. A., Aikawa, M., & Weissleder, R. (2007) · Circulation · doi:10.1161/circulationaha.107.732867 · Cited by 698
Yahagi, K., Kolodgie, F. D., Lutter, C., Mori, H., Romero, M. E., Finn, A. V., & Virmani, R. (2017) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.306256 · Cited by 573
Calcification in Aortic Stenosis
Pawade, T. A., Newby, D. E., & Dweck, M. R. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.05.066 · Cited by 397
Motskin, M., Wright, D. M., Muller, K., Kyle, N., Gard, T. G., Porter, A. E., & Skepper, J. N. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.02.044 · Cited by 364
Metadata
- Authors
- Nadra, I., Mason, J. C., Philippidis, P., Florey, O., Smythe, C. D. W., McCarthy, G. M., Landis, R. C., & Haskard, D. O.
- Venue
- Circulation Research
- Published
- 2005-06-24
- Volume
- 96
- Issue
- 12
- Pages
- 1248-1256
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2122938990
- Cited by
- 360
- References
- 6
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nadra, I., Mason, J. C., Philippidis, P., Florey, O., Smythe, C. D. W., McCarthy, G. M., Landis, R. C., & Haskard, D. O. (2005). Proinflammatory Activation of Macrophages by Basic Calcium Phosphate Crystals via Protein Kinase C and MAP Kinase Pathways: A Vicious Cycle of Inflammation and Arterial Calcification? Circulation Research. https://doi.org/10.1161/01.res.0000171451.88616.c2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
