Thematic review series: the immune system and atherogenesis. Recent insights into the biology of macrophage scavenger receptors
Open accessAbstract
Scavenger receptors were originally defined by their ability to bind and internalize modified lipoproteins. Macrophages express at least six structurally different cell surface receptors for modified forms of LDL that contribute to foam cell formation in atherosclerosis. In addition to their role in the pathology of atherosclerosis, macrophage scavenger receptors, especially SR-A, play critical roles in innate immunity, apoptotic cell clearance, and tissue homeostasis. In this review, we highlight recent advances in understanding the biology of macrophage scavenger receptors as pattern recognition receptors for both infectious nonself (pathogens) and modified self (apoptotic cells and modified LDL). We critically evaluate the potential of scavenger receptors and their ligands as targets for therapeutic intervention in human disease.
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Associations between self-reported physical activity and TNFR1, TNFR2, IL-6, and CRP in healthy men and women became non-significant after adjusting for BMI and leptin.
“In contrast, the associations found between self-reported physical activity and TNFR1, TNFR2, IL-6 and CRP concentrations in a study including healthy men from the Men's Health Professionals' Follow-Up Study and healthy women from the Nurses' Health Study (243) were no longer significant when adjusting for BMI and leptin.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [243]
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References 131 · Cited by 211
- Authors
- Greaves, D. R., & Gordon, S.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Greaves, David R.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 46
- Issue
- 1
- Pages
- 11-20
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2049653248
- Cited by
- 211
- References
- 131
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 8 · 2014: 5 · 2013: 13 · 2012: 13
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- macrophage scavenger receptor, atherogenesis, atherosclerosis, modified lipoproteins, scavenger receptor A, foam cell formation, pattern recognition receptors, innate immunity, efferocytosis, modified LDL, therapeutic target
- MeSH terms
- Animals, Foam Cells, Humans, Immunity, Ligands, Lipoproteins, LDL, Macrophages, Receptors, Immunologic, Receptors, Scavenger, Scavenger Receptors, Class A
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