Protein Kinase G Transmits the Cardioprotective Signal From Cytosol to Mitochondria

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Using hydrogen sulfide to design and develop drugs

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Contribution of Delayed Intracellular pH Recovery to Ischemic Postconditioning Protection

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Protein kinase C-ε coimmunoprecipitates with cytochrome oxidase subunit IV and is associated with improved cytochrome-coxidase activity and cardioprotection

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Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G

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Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury

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Redox Control of Cardiac Excitability

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cGMP-Dependent Protein Kinases (cGK)

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Alteration in Erythropoietin-Induced Cardioprotective Signaling by Postinfarct Ventricular Remodeling

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Alterations in mitochondrial function as a harbinger of cardiomyopathy: Lessons from the dystrophic heart

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Myocardial protection against reperfusion injury: The cGMP pathway

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Redox signaling triggers protection during the reperfusion rather than the ischemic phase of preconditioning

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Infarct limitation by a protein kinase G activator at reperfusion in rabbit hearts is dependent on sensitizing the heart to A2b agonists by protein kinase C

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Interactions between nitric oxide, oxygen, reactive oxygen species and reactive nitrogen species

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Postconditioning leads to an increase in protein S-nitrosylation

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The divergent roles of protein kinase C epsilon and delta in simulated ischaemia–reperfusion injury in human myocardium

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Roles of the nitric oxide signaling pathway in cardiac ischemic preconditioning against myocardial ischemia-reperfusion injury

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Mitochondrial Permeability Transition in Cardiac Cell Injury and Death

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Cardioprotective PKG-independent NO signaling at reperfusion

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Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release

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Diazoxide postconditioning induces mitochondrial protein S-Nitrosylation and a redox-sensitive mitochondrial phosphorylation/translocation of RISK elements: no role for SAFE

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Pharmacological and physiological stimuli do not promote Ca2+-sensitive K+channel activity in isolated heart mitochondria

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Mechanisms of growth-promoting and tumor-protecting effects of epithelial nicotinic acetylcholine receptors

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Molecular aspects of ischaemic postconditioning

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Therapeutic Implications for PDE2 and cGMP/cAMP Mediated Crosstalk in Cardiovascular Diseases

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Orphan targets for reperfusion injury

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Structure-activity relationships study of isothiocyanates for H2S releasing properties: 3-Pyridyl-isothiocyanate as a new promising cardioprotective agent

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Diazoxide acts more as a PKC‐ɛ activator, and indirectly activates the mitochondrial KATP channel conferring cardioprotection against hypoxic injury

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Mitochondrial Therapeutics for Cardioprotection

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Evaluation of (4-[18F]Fluorophenyl)triphenylphosphonium Ion. A Potential Myocardial Blood Flow Agent for PET

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The dynamic interplay between cardiac mitochondrial health and myocardial structural remodeling in metabolic heart disease, aging, and heart failure

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Phosphodiesterase 5 inhibitors prevent 3,4‐methylenedioxymethamphetamine‐induced 5‐HT deficits in the rat

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Circadian influences on myocardial infarction

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BAY 58-2667, a nitric oxide-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts

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Infarct size limitation by adrenomedullin: protein kinase A but not PI3-kinase is linked to mitochondrial KCa channels

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Semaglutide inhibits ischemia/reperfusion-induced cardiomyocyte apoptosis through activating PKG/PKCε/ERK1/2 pathway

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Increasing cGMP-dependent protein kinase I activity attenuates cisplatin-induced kidney injury through protection of mitochondria function

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Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury

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A really radical observation

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Pharmacological targets revealed by myocardial postconditioning

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ATP Synthase K+- and H+-fluxes Drive ATP Synthesis and Enable Mitochondrial K+-“Uniporter” Function: II. Ion and ATP Synthase Flux Regulation

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Nrf2-regulated antioxidant response is activated by protein kinase C in postconditioned rat hearts

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MitoKATP activity in healthy and ischemic hearts

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Prospects for Creation of Cardioprotective Drugs Based on Cannabinoid Receptor Agonists

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The mitochondrial permeability transition pore as a target of cardioprotective signaling

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Cardiac mitochondrial ATP‐sensitive potassium channel is activated by nitric oxide in vitro

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Nitric oxide/cGMP signalling mediates the cardioprotective action of adrenomedullin in reperfused myocardium

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New properties of mitochondrial ATP-regulated potassium channels

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Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation

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Nicorandil opens mitochondrial KATP channels not only directly but also through a NO-PKG-dependent pathway

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Differential loss of cytochrome-coxidase subunits in ischemia-reperfusion injury: exacerbation of COI subunit loss by PKC-ε inhibition

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Sarcoplasmic ATP-sensitive potassium channel blocker HMR1098 protects the ischemic heart: Implication of calcium, complex I, reactive oxygen species and mitochondrial ATP-sensitive potassium channel

Pasdois, P., Beauvoit, B. P., Costa, A. D. T., Jaspard‐Vinassa, B., Tariosse, L., Bonoron‐Adèle, S., Garlid, K., & Santos, P. D. D. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.12.014 · Cited by 30

Focus on: The cardiovascular system: what did we learn from the French (Paradox)?

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Dual regulation of the ATP-sensitive potassium channel by activation of cGMP-dependent protein kinase

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New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles: Mitochondrial Ion Channels and Cardioprotection

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Isoflurane Activates Human Cardiac Mitochondrial Adenosine Triphosphate-Sensitive K+ Channels Reconstituted in Lipid Bilayers

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Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG

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Diosgenin-induced protection against myocardial ischaemia-reperfusion injury is mediated by mitochondrial K ATP channels in a rat model

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Current trends and future perspectives for heart failure treatment leveraging cGMP modifiers and the practical effector PKG

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Endothelial nitric oxide synthase is not necessary for the early phase of ischemic preconditioning in the mouse

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Effects of soluble guanylate cyclase activation on heart transplantation in a rat model

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Expression of amyloid beta peptide in human platelets: Pivotal role of the phospholipase Cγ2-protein kinase C pathway in platelet activation

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Isoflurane Inhaled at the Onset of Reperfusion Potentiates the Cardioprotective Effect of Ischemic Postconditioning Through a NO-dependent Mechanism

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Signaling Mechanisms in Ischemic Preconditioning

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Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC

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Increased protein S-nitrosylation in mitochondria: a key mechanism of exercise-induced cardioprotection

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Protective Effects of Shenfu Injection against Myocardial Ischemia–Reperfusion Injury via Activation of eNOS in Rats

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Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger

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Remote Ischemic Preconditioning Stimulus Decreases the Expression of Kinin Receptors in Human Neutrophils

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NO/cGMP/PKG signaling pathway induces magnesium release mediated by mitoKATP channel opening in rat hippocampal neurons

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Remote ischaemic pre‐conditioning for the prevention of acute kidney injury

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Stimulation of neuronal KATPchannels by cGMP-dependent protein kinase: involvement of ROS and 5-hydroxydecanoate-sensitive factors in signal transduction

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Minoxidil prevents 3,4‐methylenedioxymethamphetamine‐induced serotonin depletions: role of mitochondrial ATP‐sensitive potassium channels, Akt and ERK

Goñi‐Allo, B., Puerta, E., Ramos, M., Lasheras, B., Jordán, J., & Aguirre, N. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05042.x · Cited by 23

Cardioprotection by Regular Ethanol Consumption: Potential Mechanisms and Clinical Application

Miyamae, M., Kaneda, K., Domae, N., & Figueredo, V. M. (2010) · Current Drug Abuse Reviews · doi:10.2174/1874473711003010039 · Cited by 22

cGMP and mitochondrial K+ channels—Compartmentalized but closely connected in cardioprotection

Łukowski, R., Santos, M. C., Kuret, A., & Ruth, P. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15536 · Cited by 22

Myocardial ischemic protection in natural mammalian hibernation

Yan, L., Kudej, R. K., Vatner, D. E., & Vatner, S. F. (2015) · Basic Research in Cardiology · doi:10.1007/s00395-015-0462-0 · Cited by 22

Myocardial ischemic conditioning: Physiological aspects and clinical applications in cardiac surgery

Bousselmi, R., Lebbi, A., & Ferjani, M. (2013) · Journal of the Saudi Heart Association · doi:10.1016/j.jsha.2013.11.001 · Cited by 22

Targets of cGMP/cGKI in Cardiac Myocytes

Adler, J., Kuret, A., Längst, N., & Łukowski, R. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000817 · Cited by 21

Sildenafil Citrate Augments Myocardial Protection in Heart Transplantation

Botha, P., MacGowan, G. A., & Dark, J. H. (2010) · Transplantation · doi:10.1097/tp.0b013e3181c42b22 · Cited by 21

The Role of cGMP-Dependent Protein Kinase in Controlling Cardiomyocyte cGMP

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KATP channels are regulators of programmed cell death and targets for the creation of novel drugs against ischemia/reperfusion cardiac injury

Маслов, Л. Н., Popov, S. V., Naryzhnaya, N. V., Mukhomedzyanov, А. V., Kurbatov, B. K., Андреевич, Д. И., Boshchenko, A. A., Prasad, N. R., Ma, H., Zhang, Y., et al. (2023) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12924 · Cited by 21

Pathophysiologic role of ischemia reperfusion injury: A review

Vishwakarma, V. K., Upadhyay, P. K., Gupta, J. K., & Yadav, H. N. (2017) · Journal of Indian College of Cardiology · doi:10.1016/j.jicc.2017.06.017 · Cited by 20

Neuroprotective effects of nitric oxide donor NOC-18 against brain ischemia-induced mitochondrial damages: role of PKG and PKC

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Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons

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Cardioprotective effect of thyroid hormone is mediated by AT2 receptor and involves nitric oxide production via Akt activation in mice

da Silva, I. B., Gomes, D. A., Alenina, N. V., Bäder, M., Santos, R. A. S., & Barreto‐Chaves, M. L. M. (2017) · Heart and Vessels · doi:10.1007/s00380-017-1101-5 · Cited by 18

Pathological Responses of Cardiac Mitochondria to Burn Trauma

Wang, M., Scott, S. R., Koniaris, L. G., & Zimmers, T. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186655 · Cited by 17

A combination of ischemic preconditioning and allopurinol protects against ischemic injury through a nitric oxide-dependent mechanism

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Molecular Mechanisms of Ischemic Conditioning: Translation Into Patient Outcomes

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Morphine Postconditioning Protects Against Reperfusion Injury: the Role of Protein Kinase C-Epsilon, Extracellular Signal-Regulated Kinase 1/2 and Mitochondrial Permeability Transition Pores

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Evidence for an ATP-sensitive K+ channel in mitoplasts isolated from Trypanosoma cruzi and Crithidia fasciculata

Costa, A. D. T., & Krieger, M. A. (2009) · International Journal for Parasitology · doi:10.1016/j.ijpara.2009.01.002 · Cited by 17

Mitochondrial PKC and Mitochondrial ATP-Sensitive K Channel Copurify and Coreconstitute to Form a Functioning Signaling Module in Proteoliposomes

Costa, R. D. T., Burton, J. R., Costa, C. L., & Garlid, K. (2015)

cGMP signalling in pre- and post-conditioning: the role of mitochondria

Costa, A. D. T., Pierre, S. V., Cohen, M. V., Downey, J. M., & Garlid, K. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm050 · Cited by 141

Review cGMP signalling in pre- and post-conditioning: the role of mitochondria

Costa, R. D. T., Pierre, R. V., Cohen, M. V., Downey, J. M., & Garlid, K. (2014)

Cardioprotection: spotlight on PKG

Cohen, M. V., & Downey, J. M. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707453 · Cited by 39

MitoKATP, H2O2, and PKCε – completing the cycle

Costa, A. D. T., & Garlid, K. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.03.126