The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Rho Kinases in Cardiovascular Physiology and Pathophysiology
Abstract
Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have been found to regulate a wide range of fundamental cell functions such as contraction, motility, proliferation, and apoptosis. Abnormal activation of the RhoA/ROCK pathway has been observed in major cardiovascular disorders such as atherosclerosis, restenosis, hypertension, pulmonary hypertension, and cardiac hypertrophy. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of ROCK signaling and its roles in cardiovascular physiology and pathophysiology.
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Cites
Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase
Laufs, U., & Liao, J. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.24266 · Cited by 1,035
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
Sebbagh, M., Renvoizé, C., Hamelin, J., Riché, N., Bertoglio, J., & Bréard, J. (2001) · Nature Cell Biology · doi:10.1038/35070019 · Cited by 915
Cited by
Apoptotic cell clearance: basic biology and therapeutic potential
Poon, I. K. H., Lucas, C. D., Rossi, A. G., & Ravichandran, K. S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3607 · Cited by 1,223
RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells
Li, B., Antonyak, M. A., Zhang, J., & Cerione, R. A. (2012) · Oncogene · doi:10.1038/onc.2011.636 · Cited by 377
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
Stockton, R. A., Shenkar, R., Awad, I. A., & Ginsberg, M. H. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091258 · Cited by 351
Regulation of the Pulmonary Circulation in the Fetus and Newborn
Gao, Y., & Raj, J. U. (2010) · Physiological Reviews · doi:10.1152/physrev.00032.2009 · Cited by 345
Guilluy, C., Brégeon, J., Toumaniantz, G., Rolli-Derkinderen, M., Retailleau, K., Loufrani, L., Henrion, D., Scalbert, E., Bril, A., Torres, R. M., et al. (2010) · Nature Medicine · doi:10.1038/nm.2079 · Cited by 256
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Metadata
- Authors
- Loirand, G., Guérin, P., & Pacaud, P.
- Venue
- Circulation Research
- Published
- 2006-02-17
- Volume
- 98
- Issue
- 3
- Pages
- 322-334
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2117968545
- Cited by
- 547
- References
- 2
- FWCI
- 13.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Loirand, G., Guérin, P., & Pacaud, P. (2006). Rho Kinases in Cardiovascular Physiology and Pathophysiology. Circulation Research. https://doi.org/10.1161/01.res.0000201960.04223.3c
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