Apoptotic cell clearance: basic biology and therapeutic potential
Open accessAbstract
The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and uptake, and the subsequent biological responses, are increasingly better defined. The detection and disposal of apoptotic cells generally promote an anti-inflammatory response at the tissue level, as well as immunological tolerance. Consequently, defects in apoptotic cell clearance have been linked with various inflammatory diseases and autoimmunity. Conversely, under certain conditions, such as the killing of tumour cells by specific cell-death inducers, the recognition of apoptotic tumour cells can promote an immunogenic response and antitumour immunity. Here, we review the current understanding of the complex process of apoptotic cell clearance in physiology and pathology, and discuss how this knowledge could be harnessed for new therapeutic strategies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Both signaling pathways governing apoptotic cell removal converge in activation of Rho GTPases such as Rac1 to promote actin polymerization, membrane ruffling, and phagocytosis.
“Both pathways finally converge in the activation of Rho GTPases such as Rac1 to promote actin polymerization, membrane ruffling, and phagocytosis (131, 132).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [132]
Apoptotic cells release 'find me' and expose 'eat me' signals such as PS, lysoPS, cardiolipin, calreticulin, CD31, fractalkine, and small amounts of nucleotides, which are recognized by phagocytes promoting efferocytosis.
“Apoptotic cells release ‘find me’ and expose ‘eat me’ signals such as PS, lysoPS, cardiolipin, calreticulin, and CD31, as well as the chemokine fractalkine (CX3CL1 as recognized by CX3CR1) and small amounts of nucleotides (ATP, UTP). These ligands are recognized by phagocytes promoting efferocytosis (131, 132).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [132]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268 · see citing works
Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,848 · see citing works
Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321 · see citing works
Immunogenic Cell Death in Cancer Therapy
Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303 · see citing works
Immunogenic cell death and DAMPs in cancer therapy
Krysko, D. V., Garg, A. D., Kaczmarek, A., Krysko, O., Agostinis, P., & Vandenabeele, P. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3380 · Cited by 3,223 · see citing works
Calreticulin exposure dictates the immunogenicity of cancer cell death
Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1523 · Cited by 3,216 · see citing works
Pyroptosis: host cell death and inflammation
Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,185 · see citing works
Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056 · see citing works
DAMPs, PAMPs and alarmins: all we need to know about danger
Bianchi, M. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306164 · Cited by 2,794 · see citing works
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
Condeelis, J. S., & Pollard, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.01.007 · Cited by 2,693 · see citing works
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529 · see citing works
Molecular mechanisms of necroptosis: an ordered cellular explosion
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382 · see citing works
Role of CD47 as a Marker of Self on Red Blood Cells
Oldenborg, P., Zheleznyak, A., Fang, Y., Lagenaur, C. F., Gresham, H. D., & Lindberg, F. P. (2000) · Science · doi:10.1126/science.288.5473.2051 · Cited by 1,975 · see citing works
How dying cells alert the immune system to danger
Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737 · see citing works
Willingham, S. B., Volkmer, J.-P., Gentles, A. J., Sahoo, D., Dalerba, P. D., Mitra, S. S., Wang, J., Contreras-Trujillo, H., Martin, R. K., Cohen, J. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121623109 · Cited by 1,667 · see citing works
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Elliott, M. R., Chekeni, F. B., Trampont, P. C., Lazarowski, E. R., Kadl, A., Walk, S. F., Park, D., Woodson, R. I., Ostankovich, M., Sharma, P., et al. (2009) · Nature · doi:10.1038/nature08296 · Cited by 1,654 · see citing works
Self-citationCD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
Jaiswal, S., Jamieson, C. H. M., Pang, W. W., Park, C. Y., Chao, M. P., Majeti, R., Traver, D. J., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.046 · Cited by 1,578 · see citing works
Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536 · see citing works
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
Casares, N., Pequignot, M. O., Tesniere, A., Ghiringhelli, F., Roux, S., Chaput, N., Schmitt, E., Hamai, A., Hervas-Stubbs, S., Obeid, M., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050915 · Cited by 1,512 · see citing works
Gardai, S. J., McPhillips, K. A., Frasch, S. C., Janssen, W. J., Starefeldt, A., Murphy-Ullrich, J. E., Bratton, D. L., Oldenborg, P.-A., Michalak, M., & Henson, P. M. (2005) · Cell · doi:10.1016/j.cell.2005.08.032 · Cited by 1,473 · see citing works
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
Botto, M., Dell' Agnola, C., Bygrave, A. E., Thompson, E. M., Cook, H. T., Petry, F., Loos, M., Pandolfi, P. P., & Walport, M. J. (1998) · Nature Genetics · doi:10.1038/ng0598-56 · Cited by 1,434 · see citing works
Identification of a factor that links apoptotic cells to phagocytes
Hanayama, R., Tanaka, M., Miwa, K., Shinohara, A., Iwamatsu, A., & Nagata, S. (2002) · Nature · doi:10.1038/417182a · Cited by 1,401 · see citing works
Tabas, I., Williams, K. J., & Borén, J. (2007) · Circulation · doi:10.1161/circulationaha.106.676890 · Cited by 1,399 · see citing works
Huynh, M.-L. N., Fadok, V., & Henson, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci11638 · Cited by 1,333 · see citing works
Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I
Coleman, M. L., Sahai, E. A., Yeo, M., Bosch, M., Dewar, A. L., & Olson, M. F. (2001) · Nature Cell Biology · doi:10.1038/35070009 · Cited by 1,313 · see citing works
Phagocytosis and clearance of apoptotic cells is mediated by MER
Scott, R. S., McMahon, E. J., Pop, S. M., Reap, E. A., Caricchio, R., Cohen, P. L., Earp, H. S., & Matsushima, G. K. (2001) · Nature · doi:10.1038/35075603 · Cited by 1,215 · see citing works
Identification of Tim4 as a phosphatidylserine receptor
Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T., & Nagata, S. (2007) · Nature · doi:10.1038/nature06307 · Cited by 1,180 · see citing works
Macrophage death and defective inflammation resolution in atherosclerosis
Tabas, I. (2010) · Nature Reviews Immunology · doi:10.1038/nri2675 · Cited by 1,120 · see citing works
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., Armstrong, A. J., Penuela, S., Laird, D. W., Salvesen, G. S., et al. (2010) · Nature · doi:10.1038/nature09413 · Cited by 1,120 · see citing works
Self-citationChao, M. P., Alizadeh, A. A., Tang, C. Z., Myklebust, J. H., Varghese, B., Gill, S. I., Jan, M., Cha, A. C., Chan, C. K. F., Tan, B. T., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.044 · Cited by 1,095 · see citing works
Resolution of in flammation: state of the art, definitions and terms
Serhan, C. N., Brain, S. D., Buckley, C. D., Gilroy, D. W., Haslett, C., O'Neill, L. A. J., Perretti, M., Rossi, A. G., & Wallace, J. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-7227rev · Cited by 1,045 · see citing works
Self-citationAutoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice
Hanayama, R., Tanaka, M., Miyasaka, K., Aozasa, K., Koike, M., Uchiyama, Y., & Nagata, S. (2004) · Science · doi:10.1126/science.1094359 · Cited by 992 · see citing works
Lauber, K., Bohn, E., Kröber, S. M., Xiao, Y.-J., Blumenthal, S. G., Lindemann, R. K., Marini, P., Wiedig, C., Zobywalski, A., Baksh, S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00422-7 · Cited by 967 · see citing works
Huynh, M.-L. N., Fadok, V. A., & Henson, P. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0211638 · Cited by 957 · see citing works
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
Sebbagh, M., Renvoizé, C., Hamelin, J., Riché, N., Bertoglio, J., & Bréard, J. (2001) · Nature Cell Biology · doi:10.1038/35070019 · Cited by 915 · see citing works
Nissen, S. E., Nicholls, S. J., Wolski, K., Nesto, R., Kupfer, S., Perez, A., Jure, H., De Larochellière, R., Staniloae, C. S., Mavromatis, K., et al. (2008) · JAMA · doi:10.1001/jama.299.13.1561 · Cited by 850 · see citing works
Mechanisms of pre‐apoptotic calreticulin exposure in immunogenic cell death
Panaretakis, T., Kepp, O., Brockmeier, U., Tesniere, A., Bjorklund, A., Chapman, D. C., Durchschlag, M., Joza, N., Pierron, G., van Endert, P., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.1 · Cited by 848 · see citing works
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module
Park, D., Tosello‐Trampont, A., Elliott, M. R., Lu, M., Haney, L. B., Ma, Z., Klibanov, A. L., Mandell, J. W., & Ravichandran, K. S. (2007) · Nature · doi:10.1038/nature06329 · Cited by 848 · see citing works
Self-citationA novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death
Garg, A. D., Krysko, D. V., Verfaillie, T., Kaczmarek, A., Ferreira, G. B., Marysael, T., Rubio, N., Firczuk, M., Mathieu, C., Roebroek, A. J. M., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.497 · Cited by 800 · see citing works
CD24 and Siglec-10 Selectively Repress Tissue Damage–Induced Immune Responses
Chen, G.-Y., Tang, J., Zheng, P., & Liu, Y. (2009) · Science · doi:10.1126/science.1168988 · Cited by 786 · see citing works
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
Sancho, D., Joffre, O. P., Keller, A. M., Rogers, N. C., Martínez, D., Hernanz-Falcón, P., Rosewell, I., & Sousa, C. R. E. (2009) · Nature · doi:10.1038/nature07750 · Cited by 750 · see citing works
The macrophage foam cell as a target for therapeutic intervention
Li, A. C., & Glass, C. K. (2002) · Nature Medicine · doi:10.1038/nm1102-1235 · Cited by 700 · see citing works
TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.
Kobayashi, N., Karisola, P., Peña-Cruz, V., Dorfman, D., Jinushi, M., Umetsu, S., Butte, M., Nagumo, H., Chernova, I., Zhu, B., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.11.011 · Cited by 688 · see citing works
A-González, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J. M., Ramírez, C. M., Díaz, M., Gallardo, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.018 · Cited by 674 · see citing works
Verhoven, B. M., Schlegel, R., & Williamson, P. R. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.5.1597 · Cited by 669 · see citing works
Infection regulates pro-resolving mediators that lower antibiotic requirements
Chiang, N., Fredman, G., Bäckhed, F., Oh, S. F., Vickery, T., Schmidt, B. A., & Serhan, C. N. (2012) · Nature · doi:10.1038/nature11042 · Cited by 664 · see citing works
Tseng, D., Volkmer, J.-P., Willingham, S. B., Contreras-Trujillo, H., Fathman, J. W., Fernhoff, N. B., Seita, J., Inlay, M. A., Weiskopf, K., Miyanishi, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305569110 · Cited by 656 · see citing works
Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis
Tabas, I. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000184783.04864.9f · Cited by 641 · see citing works
Acute Lung Injury and the Acute Respiratory Distress Syndrome
Matthay, M. A., & Zimmerman, G. A. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.f305 · Cited by 640 · see citing works
Meagher, L., Cousin, J. M., Seckl, J. R., & Haslett, C. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.11.4422 · Cited by 608 · see citing works
Rosenblatt, J., RAFF, M. C., & Cramer, L. P. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00587-5 · Cited by 602 · see citing works
Arita, M., Yoshida, M., Hong, S., Tjonahen, E., Glickman, J. N., Petasis, N. A., Blumberg, R. S., & Serhan, C. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409271102 · Cited by 590 · see citing works
Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells
Suzuki, J., Denning, D. P., Imanishi, E., Horvitz, H. R., & Nagata, S. (2013) · Science · doi:10.1126/science.1236758 · Cited by 573 · see citing works
Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production
Mevorach, D., Zhou, J. L., Song, X., & Elkon, K. B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.387 · Cited by 567 · see citing works
Dalli, J., & Serhan, C. N. (2012) · Blood · doi:10.1182/blood-2012-04-423525 · Cited by 556 · see citing works
Monocyte and Macrophage Dynamics During Atherogenesis
Ley, K. F., Miller, Y. I., & Hedrick, C. C. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.221127 · Cited by 553 · see citing works
Rho Kinases in Cardiovascular Physiology and Pathophysiology
Loirand, G., Guérin, P., & Pacaud, P. (2006) · Circulation Research · doi:10.1161/01.res.0000201960.04223.3c · Cited by 550 · see citing works
Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums
Ravichandran, K. S. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101157 · Cited by 547 · see citing works
Self-citationMacrophage Reverse Cholesterol Transport
Cuchel, M., & Rader, D. J. (2006) · Circulation · doi:10.1161/circulationaha.104.475715 · Cited by 529 · see citing works
Oram, J. F., & Heinecke, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00005.2005 · Cited by 521 · see citing works
Granulocyte Apoptosis and Its Role in the Resolution and Control of Lung Inflammation
Haslett, C. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.supplement_1.4 · Cited by 517 · see citing works
Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis
Schrijvers, D. M., De Meyer, G. R. Y., Kockx, M. M., Herman, A. G., & Martinet, W. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000166517.18801.a7 · Cited by 509 · see citing works
Rossi, A. G., Sawatzky, D. A., Walker, A., Ward, C., Sheldrake, T. A., Riley, N. A., Caldicott, A., Martínez‐Losa, M., Walker, T. R., Duffin, R., et al. (2006) · Nature Medicine · doi:10.1038/nm1468 · Cited by 506 · see citing works
Self-citationLi, F., Huang, Q., Jiang, C., Peng, Y., Roop, D. R., Bedford, J. S., & Li, C. (2010) · Science Signaling · doi:10.1126/scisignal.2000634 · Cited by 494 · see citing works
Engineered SIRPα Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies
Weiskopf, K., Ring, A. M., Ho, C. C. M., Volkmer, J.-P., Levin, A. M., Volkmer, A. K., Özkan, E., Fernhoff, N. B., van de Rijn, M., Weissman, I. L., et al. (2013) · Science · doi:10.1126/science.1238856 · Cited by 493 · see citing works
Bratton, D. L., Fadok, V. A., Richter, D., Kailey, J. M., Guthrie, L. A., & Henson, P. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.42.26159 · Cited by 485 · see citing works
CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis
Truman, L. A., Ford, C. A., Pasikowska, M., Pound, J. D., Wilkinson, S. J., Dumitriu, I. E., Melville, L., Melrose, L. A., Ogden, C. A., Nibbs, R., et al. (2008) · Blood · doi:10.1182/blood-2008-06-162404 · Cited by 473 · see citing works
Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor
Park, S.-Y., Jung, M.-Y., Kim, H.-J., Lee, S., Kim, S.-Y., Lee, B.-H., Kwon, T.-H., Park, R. W., & Kim, I. T. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402242 · Cited by 464 · see citing works
Hodge, S., Hodge, G., Scicchitano, R., Reynolds, P. N., & Holmes, M. (2003) · Immunology & Cell Biology · doi:10.1046/j.1440-1711.2003.t01-1-01170.x · Cited by 440 · see citing works
Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
NAKAYAMA, M., Akiba, H., Takeda, K., Kojima, Y., Hashiguchi, M., Azuma, M., Yagita∥, H., & Okumura, K. (2009) · Blood · doi:10.1182/blood-2008-10-185884 · Cited by 434 · see citing works
Annexin I Is an Endogenous Ligand that Mediates Apoptotic Cell Engulfment
Arur, S., Uche, U. E., Rezaul, K., Fong, M., Scranton, V., Cowan, A. E., Mohler, W., & Han, D. K. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00090-x · Cited by 434 · see citing works
A novel anti-inflammatory role for simvastatin in inflammatory arthritis.
Leung, B. P., Sattar, N., Crilly, A., Prach, M., McCarey, D. W., Payne, H., Madhok, R., Campbell, C., Gracie, J. A., Liew, F. Y., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1524 · Cited by 434 · see citing works
Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation
Serhan, C. N. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100322 · Cited by 421 · see citing works
The Alarmin Interleukin-33 Drives Protective Antiviral CD8 + T Cell Responses
Bonilla, W. V., Fröhlich, A., Senn, K., Kallert, S. M., Fernandez, M., Johnson, S., Kreutzfeldt, M., Hegazy, A. N., Schrick, C., Fallon, P. G., et al. (2012) · Science · doi:10.1126/science.1215418 · Cited by 417 · see citing works
Anderson, H. A., Maylock, C. A., Williams, J. A., Paweletz, C. P., Shu, H., & Shacter, E. B. (2002) · Nature Immunology · doi:10.1038/ni871 · Cited by 405 · see citing works
Seitz, H., Camenisch, T. D., Lemke, G., Earp, H. S., & Matsushima, G. K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5635 · Cited by 403 · see citing works
Miller, Y. I., Viriyakosol, S., Binder, C. J., Feramisco, J. R., Kirkland, T. N., & Witztum, J. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209634200 · Cited by 398 · see citing works
Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
Brown, S., Heinisch, I., Ross, E., Shaw, K., Buckley, C. D., & Savill, J. (2002) · Nature · doi:10.1038/nature00811 · Cited by 390 · see citing works
Increased Atherosclerosis in Hyperlipidemic Mice With Inactivation of ABCA1 in Macrophages
Aiello, R. J., Brees, D., Bourassa, P.-A., Royer, L., Lindsey, S., Coskran, T., Haghpassand, M., & Francone, O. L. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000014804.35824.da · Cited by 390 · see citing works
Spisek, R., Charalambous, A., Mazumder, A., Vesole, D. H., Jagannath, S., & Dhodapkar, M. V. (2007) · Blood · doi:10.1182/blood-2006-10-054221 · Cited by 388 · see citing works
Rumore, P. M., & Steinman, C. R. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114716 · Cited by 366 · see citing works
Gude, D., Alvarez, S. E., Paugh, S. W., Mitra, P., Yu, J., Griffiths, R., Barbour, S. E., Milstien, S., & Spiegel, S. (2008) · The FASEB Journal · doi:10.1096/fj.08-107169 · Cited by 364 · see citing works
Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair
Harel-Adar, T., Ben-Mordechai, T., Amsalem, Y., Feinberg, M. S., Leor, J., & Cohen, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015623108 · Cited by 363 · see citing works
Thorp, E., Cui, D., Schrijvers, D. M., Kuriakose, G., & Tabas, I. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.167197 · Cited by 357 · see citing works
Molecular mechanisms of late apoptotic/necrotic cell clearance
Poon, I. K. H., Hulett, M. D., & Parish, C. R. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.195 · Cited by 353 · see citing works
Self-citationMulti-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4
Levy, B. D., Sanctis, G. T. D., Devchand, P. R., Kim, E., Ackerman, K. G., Schmidt, B. A. R., Szczeklik, W., Drazen, J. M., & Serhan, C. N. (2002) · Nature Medicine · doi:10.1038/nm748 · Cited by 350 · see citing works
Modulation of Macrophage Efferocytosis in Inflammation
Johnson, D. K., Frasch, S. C., Fernandez-Boyanapalli, R. F., Henson, P. M., & Bratton, D. L. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00057 · Cited by 346 · see citing works
The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments
Zhang, J., Czabotar, P. E., Policheni, A. N., Caminschi, I., Wan, S. S., Kitsoulis, S., Tullett, K. M., Robin, A. Y., Brammananth, R., van Delft, M. F., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.009 · Cited by 342 · see citing works
Zhu, X., Owen, J. S., Wilson, M. D., Li, H., Griffiths, G. L., Thomas, M. J., Hiltbold, E. M., Fessler, M. B., & Parks, J. S. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m006486 · Cited by 331 · see citing works
Ueki, S., Melo, R. C. N., Ghiran, I. C., Spencer, L. A., Dvořàk, A. M., & Weller, P. F. (2013) · Blood · doi:10.1182/blood-2012-05-432088 · Cited by 329 · see citing works
Paleolog, E. M., Young, S., Stark, A. C., McCloskey, R. V., Feldmann, M., & Maini, R. N. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199807)41:7 · Cited by 318 · see citing works
Neutrophils undergo apoptosis following ingestion of Escherichia coli
Watson, R. W. G., Redmond, H. P., Wang, J. H., Condron, C. M., & Bouchier‐Hayes, D. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3986 · Cited by 303 · see citing works
Negative Regulation of Phagocytosis in Macrophages by the CD47-SHPS-1 System
Okazawa, H., Motegi, S., Ohyama, N., Ohnishi, H., Tomizawa, T., Kaneko, Y., Oldenborg, P., Ishikawa, O., & Matozaki, T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2004 · Cited by 303 · see citing works
Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes
Liu, Y., Cousin, J. M., Hughes, J., Van Damme, J., Seckl, J. R., Haslett, C., Dransfield, I., Savill, J., & Rossi, A. G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3639 · Cited by 299 · see citing works
Self-citationC1q, Autoimmunity and Apoptosis
Botto, M. (2002) · Immunobiology · doi:10.1078/0171-2985-00141 · Cited by 291 · see citing works
El Kebir, D., Gjorstrup, P., & Filep, J. G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206641109 · Cited by 289 · see citing works
Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation
Juncadella, I. J., Kadl, A., Sharma, A. K., Shim, Y. M., Hochreiter, A. E., Borish, L., & Ravichandran, K. S. (2012) · Nature · doi:10.1038/nature11714 · Cited by 287 · see citing works
Self-citationPhosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion
Hochreiter, A. E., Lee, C. S., Kinchen, J. M., Sokolowski, J. D., Arandjelovic, S., Call, J. A., Klibanov, A. L., Yan, Z., Mandell, J. W., & Ravichandran, K. S. (2013) · Nature · doi:10.1038/nature12135 · Cited by 286 · see citing works
Self-citationThe Macrophage Cholesterol Exporter ABCA1 Functions as an Anti-inflammatory Receptor
Tang, C., Liu, Y., Kessler, P. S., Vaughan, A. M., & Oram, J. F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.047472 · Cited by 284 · see citing works
Schrijvers, D. M., DEMEYER, G., HERMAN, A., & Martinet, W. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.09.005 · Cited by 278 · see citing works
Eosinophil Apoptosis and the Resolution of Airway Inflammation in Asthma
Woolley, K. L., Gibson, P. G., Carty, K., Wilson, A., Twaddell, S. H., & Woolley, M. J. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.1.8680686 · Cited by 257 · see citing works
Levkau, B., Herren, B., Koyama, H., Ross, R., & Raines, E. W. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.4.579 · Cited by 257 · see citing works
Lactadherin Deficiency Leads to Apoptotic Cell Accumulation and Accelerated Atherosclerosis in Mice
Ait-Oufella, H., Kinugawa, K., Zoll, J., Simon, T., Boddaert, J., Heeneman, S., Blanc-Brude, O., Barateau, V., Potteaux, S., Merval, R., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.662080 · Cited by 255 · see citing works
Ishimoto, Y., Ohashi, K., Mizuno, K., & Nakano, T. (2000) · Journal of Biochemistry (Tokyo) · doi:10.1093/oxfordjournals.jbchem.a022622 · Cited by 248 · see citing works
Brancolini, C., Lazarević, D., Rodriguez, J., & Schneider, C. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.3.759 · Cited by 236 · see citing works
12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance
Uderhardt, S., i, M. H., Oskolkova, O., Aschermann, S., Bicker, W., Ipseiz, N., Sarter, K., Frey, B., Rothe, T., Voll, R. E., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.010 · Cited by 235 · see citing works
He, M. T., Kubo, H., Morimoto, K., Fujino, N., Suzuki, T., Takahasi, T., Yamada, M., Yamaya, M., Maekawa, T., Yamamoto, Y., et al. (2011) · EMBO Reports · doi:10.1038/embor.2011.28 · Cited by 232 · see citing works
Michlewska, S., Dransfield, I., Megson, I. L., & Rossi, A. G. (2008) · The FASEB Journal · doi:10.1096/fj.08-121228 · Cited by 228 · see citing works
Self-citationCCR7 is involved in the migration of neutrophils to lymph nodes
Beauvillain, C., Cunin, P., Doni, A., Scotet, M., Jaillon, S., Loiry, M.-L., Magistrelli, G., Masternak, K., Chevailler, A., Delneste, Y., et al. (2010) · Blood · doi:10.1182/blood-2009-11-254490 · Cited by 227 · see citing works
Differences between the clearance of apoptotic cells by professional and non-professional phagocytes
Parnaik, R., RAFF, M. C., & Scholes, J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00598-4 · Cited by 216 · see citing works
Morimoto, K., Janssen, W. J., Fessler, M. B., McPhillips, K. A., Borges, V. M., Bowler, R. P., Xiao, Y., Kench, J. A., Henson, P. M., & Vandivier, R. W. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.12.7657 · Cited by 215 · see citing works
Gregory, C. D., & Pound, J. D. (2010) · The Journal of Pathology · doi:10.1002/path.2792 · Cited by 214 · see citing works
Perniok, A., Wedekind, F., i, M. H., Specker, C., & Schneider, M. (1998) · Lupus · doi:10.1191/096120398678919804 · Cited by 212 · see citing works
Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin
Bournazou, I., Pound, J. D., Duffin, R., Bournazos, S., Melville, L. A., Brown, S. B., Rossi, A. G., & Gregory, C. D. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36226 · Cited by 212 · see citing works
Self-citation15-Epi-lipoxin A4 Inhibits Myeloperoxidase Signaling and Enhances Resolution of Acute Lung Injury
Kebir, D. E., József, L., Pan, W., Wang, L., Petasis, N. A., Serhan, C. N., & Filep, J. G. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200810-1601oc · Cited by 206 · see citing works
Stuart, L. M., Takahashi, K., Shi, L., Savill, J., & Ezekowitz, R. A. B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3220 · Cited by 205 · see citing works
Constitutive exposure of phosphatidylserine on viable cells
Segawa, K., Suzuki, J., & Nagata, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114799108 · Cited by 203 · see citing works
Wood, W., Turmaine, M., Weber, R., Camp, V., Maki, R. A., McKercher, S. R., & Martin, P. B. (2000) · Development · doi:10.1242/dev.127.24.5245 · Cited by 201 · see citing works
Pharmacotherapy of Acute Lung Injury and the Acute Respiratory Distress Syndrome
Cepkova, M., & Matthay, M. A. (2006) · Journal of Intensive Care Medicine · doi:10.1177/0885066606287045 · Cited by 198 · see citing works
Vago, J. P., Nogueira, C. R. C., Tavares, L. P., Soriani, F. M., Lopes, F., Russo, R. C., Pinho, V., Teixeira, M. M., & Sousa, L. P. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0112008 · Cited by 192 · see citing works
Neutrophil transmigration triggers repair of the lung epithelium via β-catenin signaling
Zemans, R. L., Briones, N. J., Campbell, M., McClendon, J. D., Young, S. K., Suzuki, T., Yang, I. V., Langhe, S. D., Reynolds, S. D., Mason, R. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110144108 · Cited by 189 · see citing works
ATP-binding cassette transporter AI and its role in HDL formation
Lee, J., & Parks, J. S. (2005) · Current Opinion in Lipidology · doi:10.1097/00041433-200502000-00005 · Cited by 187 · see citing works
Macrophage Recognition of ICAM-3 on Apoptotic Leukocytes
Moffatt, O., Devitt, A., Bell, E. D., Simmons, D. L., & Gregory, C. D. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6800 · Cited by 185 · see citing works
Koedel, U., Frankenberg, T., Kirschnek, S., Obermaier, B., Häcker, H., Paul, R. H., & Häcker, G. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000461 · Cited by 179 · see citing works
Bondanza, A., Zimmermann, V. S., Rovere, P. Q., Turnay, J., Dumitriu, I. E., Stach, C. M., Voll, R. E., Gaipl, U. S., Bertling, W. M., Pöschl, E., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040327 · Cited by 176 · see citing works
Eck, M. V., Singaraja, R. R., Ye, D., Hildebrand, R. B., James, E. R., Hayden, M. R., & van Berkel, T. J. C. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000208364.22732.16 · Cited by 167 · see citing works
Complement C1q Reduces Early Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice
Bhatia, V. K., Yun, S., Leung, V. W. Y., Grimsditch, D. C., Benson, G. M., Botto, M., Boyle, J. J., & Haskard, D. O. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060406 · Cited by 166 · see citing works
Monks, J., Smith-Steinhart, C., Kruk, E. R., Fadok, V. A., & Henson, P. M. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.065045 · Cited by 158 · see citing works
Regulation of endothelial monocyte-activating polypeptide II release by apoptosis
Knies, U. E., Behrensdorf, H. A., Mitchell, C. A., Deutsch, U., Risau, W., Drexler, H. C. A., & Clauss, M. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12322 · Cited by 157 · see citing works
Opposite Effects of Rho Family GTPases on Engulfment of Apoptotic Cells by Macrophages
Nakaya, M., Tanaka, M., Okabe, Y., Hanayama, R., & Nagata, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510972200 · Cited by 155 · see citing works
Impaired Phagocytosis in Localized Aggressive Periodontitis: Rescue by Resolvin E1
Fredman, G., Oh, S. F., Ayilavarapu, S., Hastürk, H., Serhan, C. N., & Dyke, T. E. V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024422 · Cited by 154 · see citing works
Engulfment of Apoptotic Cells Is Negatively Regulated by Rho-mediated Signaling
Tosello‐Trampont, A., Nakada‐Tsukui, K., & Ravichandran, K. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306079200 · Cited by 153 · see citing works
Self-citationHuynh, M.-L. N., Malcolm, K. C., Kotaru, C., Tilstra, J. A., Westcott, J. Y., Fadok, V. A., & Wenzel, S. E. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200501-035oc · Cited by 151 · see citing works
Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma
Fitzpatrick, A. M., Holguín, F., Teague, W. G., & Brown, L. A. S. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.03.008 · Cited by 150 · see citing works
Shigella IpgB1 promotes bacterial entry through the ELMO–Dock180 machinery
Handa, Y., Suzuki, M., Ohya, K., Iwai, H., Ishijima, N., Koleske, A. J., Fukui, Y., & Sasakawa, C. (2006) · Nature Cell Biology · doi:10.1038/ncb1526 · Cited by 150 · see citing works
Apoptotic Cells Protect Mice against Lipopolysaccharide-Induced Shock
Ren, Y., Xie, Y., Jiang, G., B, J. F. A., Yeung, J. S. L., Li, W., Tam, P. K. H., & Savill, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4978 · Cited by 150 · see citing works
Emerging roles for lysophosphatidylserine in resolution of inflammation
Frasch, S. C., & Bratton, D. L. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.03.001 · Cited by 149 · see citing works
Intravenous apoptotic spleen cell infusion induces a TGF-β-dependent regulatory T-cell expansion
Kleinclauss, F., Perruche, S., Masson, E., Bittencourt, M. D. C., Biichlé, S., Remy-Martin, J.-P., Ferrand, C., Martin, M., Bittard, H., Chalopin, J. M., et al. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401699 · Cited by 146 · see citing works
Galectin-3 Reduces the Severity of Pneumococcal Pneumonia by Augmenting Neutrophil Function
Farnworth, S. L., Henderson, N. C., MacKinnon, A. C., Atkinson, K. M., Wilkinson, T., Dhaliwal, K., Hayashi, K., Simpson, A. J., Rossi, A. G., Haslett, C., et al. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070870 · Cited by 143 · see citing works
Self-citationCD46 Plays a Key Role in Tailoring Innate Immune Recognition of Apoptotic and Necrotic Cells
Elward, K., Griffiths, M., Mizuno, M., Harris, C. L., Neal, J. W., Morgan, B. P., & Gasque, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506579200 · Cited by 142 · see citing works
McGrath, E. E., Marriott, H. M., Lawrie, A., Francis, S., Sabroe, I., Renshaw, S. A., Dockrell, D. H., & Whyte, M. K. B. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0211062 · Cited by 138 · see citing works
Bittencourt, M. D. C., Perruche, S., Contassot, E., Fresnay, S., Baron, M.-H., Angonin, R., Aubin, F., Hervé, P., Tiberghien, P., & Saas, P. (2001) · Blood · doi:10.1182/blood.v98.1.224 · Cited by 137 · see citing works
Persistence of apoptotic cells without autoimmune disease or inflammation in CD14−/− mice
Devitt, A., Parker, K. G., Ogden, C. A., Oldreive, C., Clay, M. F., Melville, L. A., Bellamy, C. O. C., Lacy‐Hulbert, A., Gangloff, S. C., Goyert, S. M., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200410057 · Cited by 135 · see citing works
McColl, A., Bournazos, S., Franz, S., Perretti, M., Morgan, B. P., Haslett, C., & Dransfield, I. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803503 · Cited by 135 · see citing works
Fernandez-Boyanapalli, R. F., Frasch, S. C., McPhillips, K. A., Vandivier, R. W., Harry, B. L., Riches, D. W. H., Henson, P. M., & Bratton, D. L. (2008) · Blood · doi:10.1182/blood-2008-05-160564 · Cited by 133 · see citing works
HMGB1 inhibits macrophage activity in efferocytosis through binding to the αvβ3-integrin
Friggeri, A., Yang, Y., Banerjee, S., Park, Y.-J., Liu, G., & Abraham, E. H. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00152.2010 · Cited by 128 · see citing works
Borisenko, G. G., Matsura, T., Liu, S., Tyurin, V. A., Jiang, J., Serinkan, F. B., & Kagan, V. E. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(03)00083-3 · Cited by 125 · see citing works
Two-Step Engulfment of Apoptotic Cells
Toda, S., Hanayama, R., & Nagata, S. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05993-11 · Cited by 124 · see citing works
Apoptotic Cells Induce a Phosphatidylserine-Dependent Homeostatic Response from Phagocytes
Kiss, R. S., Elliott, M. R., Ma, Z., Marcel, Y. L., & Ravichandran, K. S. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.043 · Cited by 119 · see citing works
Self-citationWang, Z., Larregina, A. T., Shufesky, W. J., Perone, M. J., Montecalvo, A., Zahorchak, A. F., Thomson, A. W., & Morelli, A. E. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01308.x · Cited by 116 · see citing works
McPhillips, K. A., Janssen, W. J., Ghosh, M., Byrne, A. M., Gardai, S. J., Remigio, L. K., Bratton, D. L., Kang, J. L., & Henson, P. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.8117 · Cited by 106 · see citing works
Segundo, C., Medina, F., Rodriguez, C. S., Martı́nez-Palencia, R., Leyva‐Cobián, F., & Brieva, J. A. (1999) · Blood · doi:10.1182/blood.v94.3.1012.415k05_1012_1020 · Cited by 105 · see citing works
Requirement of Adaptor Protein GULP during Stabilin-2-mediated Cell Corpse Engulfment
Park, S., Kang, K.-B., Thapa, N., Kim, S.-Y., Lee, S.-J., & Kim, I. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709105200 · Cited by 105 · see citing works
Antigen presentation by macrophages is enhanced by the uptake of necrotic, but not apoptotic, cells
Barker, R. N., Erwig, L.-P., Hill, K., Devine, A., Pearce, W. P., & Rees, A. J. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01774.x · Cited by 104 · see citing works
Torr, E., Gardner, D. H., Thomas, L., Goodall, D. M., Bielemeier, A., Willetts, R. S., Griffiths, H. R., Marshall, L. J., & Devitt, A. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.167 · Cited by 103 · see citing works
Defective efferocytosis by alveolar macrophages in IPF patients
Morimoto, K., Janssen, W. J., & Terada, M. (2012) · Respiratory Medicine · doi:10.1016/j.rmed.2012.08.020 · Cited by 98 · see citing works
Fernandez-Boyanapalli, R., Frasch, S. C., Riches, D. W. H., Vandivier, R. W., Henson, P. M., & Bratton, D. L. (2010) · Blood · doi:10.1182/blood-2010-02-272005 · Cited by 98 · see citing works
Fasudil, a Rho-Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice
Jiang, C., Huang, H. F., Liu, J., Wang, Y., Lu, Z., & Xu, Z. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13078293 · Cited by 96 · see citing works
Cleavage of Annexin A1 by ADAM10 during Secondary Necrosis Generates a Monocytic “Find-Me” Signal
Blume, K., Soeroes, S., Keppeler, H., Stevanović, S., Kretschmer, D., Rautenberg, M., Wesselborg, S., & Lauber, K. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004073 · Cited by 92 · see citing works
Impaired Clearance of Apoptotic Cells From Cystic Fibrosis Airways
Vandivier, R. W., Fadok, V. A., Ogden, C. A., Hoffmann, P. R., Brain, J. D., Accurso, F. J., Fisher, J. H., Greene, K. E., & Henson, P. M. (2002) · CHEST Journal · doi:10.1378/chest.121.3_suppl.89s · Cited by 87 · see citing works
Hesse, K. (1994) · Cited by 87 · see citing works
Inhibition of eosinophil migration by lactoferrin
Bournazou, I., Mackenzie, K. J., Duffin, R., Rossi, A. G., & Gregory, C. D. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2009.86 · Cited by 84 · see citing works
Self-citationRupp, J., Pfleiderer, L., Jugert, C., Möller, S., Klinger, M. H. F., Dalhoff, K., Solbach, W., Stenger, S., Laskay, T., & van Zandbergen, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006020 · Cited by 78 · see citing works
Park, S., Kim, S., Jung, M.-Y., Bae, D.-J., & Kim, I. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01993-07 · Cited by 78 · see citing works
Regression of Inflammation in Atherosclerosis by the LXR Agonist R211945
Vucic, E., Calcagno, C., Dickson, S. D., Rudd, J. H. F., Hayashi, K., Bucerius, J. A., Moshier, E. L., Mounessa, J. S., Roytman, M., Moon, M. J., et al. (2012) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2011.11.025 · Cited by 78 · see citing works
Grommes, J., Vijayan, S., Drechsler, M. D., Hartwig, H., Mörgelin, M., Dembinski, R., Jacobs, M. J. H. M., Koeppel, T. A., Binnebösel, M., Weber, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038917 · Cited by 77 · see citing works
Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen‐induced arthritis
van den Brand, B. T., Abdollahi‐Roodsaz, S., Vermeij, E. A., Bennink, M. B., Arntz, O. J., Rothlin, C. V., van den Berg, W. B., & van de Loo, F. A. J. (2012) · Arthritis & Rheumatism · doi:10.1002/art.37786 · Cited by 77 · see citing works
Moon, C., Lee, Y.-J., Park, H.-J., Chong, Y. H., & Kang, J. L. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200907-1061oc · Cited by 74 · see citing works
Flavones induce neutrophil apoptosis by down‐regulation of Mcl‐1 via a proteasomal‐dependent pathway
Lucas, C. D., Allen, K. C., Dorward, D. A., Hoodless, L. J., Melrose, L. A., Marwick, J. A., Tucker, C. S., Haslett, C., Duffin, R., & Rossi, A. G. (2012) · The FASEB Journal · doi:10.1096/fj.12-218990 · Cited by 74 · see citing works
Self-citationCaspase-mediated Cleavage of p130cas in Etoposide-induced Apoptotic Rat-1 Cells
Kook, S., Shim, S. R., Choi, S. J., Ahnn, J., Kim, J. I., Eom, S. H., Jung, Y., Paik, S. G., & Song, W. K. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.3.929 · Cited by 73 · see citing works
Ramos, G. C., Fernandes, D., Charão, C. C. T., Souza, D. G., Teixeira, M. M., & Assreuy, J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707302 · Cited by 72 · see citing works
Allograft tolerance induced by donor apoptotic lymphocytes requires phagocytosis in the recipient
Sun, E., Gao, Y., Chen, J., Roberts, A. I., Wang, X., Chen, Z., & Shi, Y. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401500 · Cited by 71 · see citing works
Buckland, J. (2002) · Nature reviews. Immunology · doi:10.1038/nri963 · Cited by 71 · see citing works
Apoptotic cell-based therapies against transplant rejection: role of recipient’s dendritic cells
Morelli, A. E., & Larregina, A. T. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0469-9 · Cited by 70 · see citing works
Liver X receptor agonist prevents the evolution of collagen-induced arthritis in mice
Park, M., Kwon, Y. J., Chung, S. J., Park, Y., & Lee, S. K. (2010) · Lara D. Veeken · doi:10.1093/rheumatology/keq007 · Cited by 70 · see citing works
The fate of E- and P-cadherin during the early stages of apoptosis
Schmeiser, K., & Grand, R. J. A. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400504 · Cited by 61 · see citing works
Lee, Y.-J., Moon, C., Lee, S. H., Park, H.-J., Seoh, J.-Y., Cho, M.-S., & Kang, J. L. (2012) · European Respiratory Journal · doi:10.1183/09031936.00096711 · Cited by 60 · see citing works
Yamaguchi, H., Fujimoto, T., Nakamura, S., Ohmura, K., Mimori, T., Matsuda, F., & Nagata, S. (2010) · European Journal of Immunology · doi:10.1002/eji.200940096 · Cited by 55 · see citing works
Wu, D., Xu, J.-Z., Wu, Y., Lafarge, J.-C., Xiao, B., Gao, P., & Zhu, D. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.04.025 · Cited by 53 · see citing works
Extracellular Histones Inhibit Efferocytosis
Friggeri, A., Banerjee, S., Xie, N., Cui, H., de Freitas, A., Zerfaoui, M., Dupont, H., Abraham, E. H., & Liu, G. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00005 · Cited by 52 · see citing works
Frasch, S. C., Fernandez-Boyanapalli, R. F., Berry, K. A. Z., Murphy, R. C., Leslie, C. C., Nick, J. A., Henson, P. M., & Bratton, D. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.438507 · Cited by 50 · see citing works
Kenyon, K. D., Cole, C., Crawford, F., Kappler, J. W., Thurman, J. M., Bratton, D. L., Boackle, S. A., & Henson, P. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003468 · Cited by 49 · see citing works
Tomita, T., Kakiuchi, Y., & Tsao, P. S. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1856 · Cited by 48 · see citing works
Hu, C., Wu, C., Tsai, H., Chang, S., Tsai, W., & Hsu, P. (2009) · Lupus · doi:10.1177/0961203309103027 · Cited by 48 · see citing works
Thymosin β4 is involved in stabilin‐2‐mediated apoptotic cell engulfment
Lee, S.-J., So, I.-S., Park, S., & Kim, I. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.03.058 · Cited by 48 · see citing works
Phagocytosis of apoptotic eosinophils but not neutrophils by bronchial epithelial cells
Sexton, D. W., Al-Rabia, M. W., Blaylock, M. G., & Walsh, G. M. (2004) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2004.02054.x · Cited by 48 · see citing works
Perruche, S., Saas, P., & Chen, W. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2750 · Cited by 46 · see citing works
Wang, Z., Shufesky, W. J., Montecalvo, A., Divito, S. J., Larregina, A. T., & Morelli, A. E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004940 · Cited by 45 · see citing works
Szodoray, P., Papp, G., Nakken, B., Harangi, M., & Zeher, M. (2010) · Autoimmunity Reviews · doi:10.1016/j.autrev.2009.12.011 · Cited by 40 · see citing works
Marwick, J. A., Dorward, D. A., Lucas, C. D., Jones, K. O., Sheldrake, T. A., Fox, S., Ward, C., Murray, J., Brittan, M., Hirani, N., et al. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0912462 · Cited by 37 · see citing works
Self-citationNilsson, A., & Oldenborg, P.-A. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.06.121 · Cited by 37 · see citing works
Deftereos, S. G., Γιαννόπουλος, Γ., Kossyvakis, C., Kaoukis, A., Raisakis, K., Panagopoulou, V., Miliou, A., Theodorakis, A., Driva, M., Pyrgakis, V. N., et al. (2011) · Heart · doi:10.1136/heartjnl-2011-300339 · Cited by 25 · see citing works
Resolution of cell-mediated airways diseases
Persson, C. G. A., & Uller, L. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-75 · Cited by 21 · see citing works
Hurst, N. P., Nuki, G., & Wallington, T. B. (1983) · Annals of the Rheumatic Diseases · doi:10.1136/ard.42.5.487 · Cited by 10 · see citing works
Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus
Gergely, P., Grossman, C., Niland, B., Puskas, F., Neupane, H., Allam, F., Banki, K., Phillips, P. E., & Perl, A. (2002) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200201)46:1 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Immunogenic cell death in cancer and infectious disease
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119 · see citing works
Pyroptosis: Mechanisms and Diseases
Yu, P., Zhang, X., Liu, N., Tang, L., Peng, C., & Chen, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00507-5 · Cited by 2,353 · see citing works
Cell death: a review of the major forms of apoptosis, necrosis and autophagy
D'Arcy, M. (2019) · Cell Biology International · doi:10.1002/cbin.11137 · Cited by 2,328 · see citing works
Necroptosis and its role in inflammation
Pasparakis, M., & Vandenabeele, P. (2015) · Nature · doi:10.1038/nature14191 · Cited by 2,148 · see citing works
Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities
Galipeau, J., & Sensébé, L. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.05.004 · Cited by 1,819 · see citing works
Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz962 · Cited by 1,601 · see citing works
Detection of immunogenic cell death and its relevance for cancer therapy
Fucikova, J., Kepp, O., Kasikova, L., Petroni, G., Yamazaki, T., Liu, P., Zhao, L., Spisek, R., Kroemer, G., & Galluzzi, L. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-03221-2 · Cited by 1,138 · see citing works
Efferocytosis in health and disease
Doran, A. C., Yurdagul, A., & Tabas, I. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0240-6 · Cited by 1,066 · see citing works
Programmed cell death as a defence against infection
Jørgensen, I., Rayamajhi, M., & Miao, E. A. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2016.147 · Cited by 1,014 · see citing works
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.137 · Cited by 1,002 · see citing works
Self-citationMacrophage defense mechanisms against intracellular bacteria
Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989 · see citing works
Plasma membrane changes during programmed cell deaths
Zhang, Y., Chen, X., Gueydan, C., & Han, J. (2017) · Cell Research · doi:10.1038/cr.2017.133 · Cited by 981 · see citing works
Phagocytosis of apoptotic cells in homeostasis
Arandjelovic, S., & Ravichandran, K. S. (2015) · Nature Immunology · doi:10.1038/ni.3253 · Cited by 959 · see citing works
Self-citationResolution of inflammation: a new therapeutic frontier
Fullerton, J. N., & Gilroy, D. W. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.39 · Cited by 937 · see citing works
Apoptosis and apoptotic body: disease message and therapeutic target potentials
Xu, X., Lai, Y., & Hua, Z. (2018) · Bioscience Reports · doi:10.1042/bsr20180992 · Cited by 923 · see citing works
The clearance of dead cells by efferocytosis
Boada-Romero, E., Martinez, J., Heckmann, B. L., & Green, D. R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0232-1 · Cited by 893 · see citing works
Focus on Extracellular Vesicles: Introducing the Next Small Big Thing
Kalra, H., Drummen, G. P. C., & Mathivanan, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020170 · Cited by 865 · see citing works
Pattern Recognition Receptors and the Host Cell Death Molecular Machinery
Amarante-Mendes, G. P., Adjemian, S., Branco, L. M., Zanetti, L. C., Weinlich, R., & Bortoluci, K. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02379 · Cited by 759 · see citing works
Tissue-specific macrophages: how they develop and choreograph tissue biology
Mass, E., Nimmerjahn, F., Kierdorf, K., & Schlitzer, A. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00848-y · Cited by 621 · see citing works
Meng, W., He, C., Hao, Y., Wang, L., Li, L., & Zhu, G. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1748758 · Cited by 618 · see citing works
Neutrophils as protagonists and targets in chronic inflammation
Soehnlein, O., Steffens, S., Hidalgo, A., & Weber, C. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.10 · Cited by 606 · see citing works
Klebsiella pneumoniae infection biology: living to counteract host defences
Bengoechea, J. A., & Sá‐Pessoa, J. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy043 · Cited by 582 · see citing works
Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells
Bosurgi, L., Cao, Y. G., Cabeza-Cabrerizo, M., Tucci, A., Hughes, L. D., Kong, Y., Weinstein, J. S., Licona-Limon, P., Schmid, E. T., Pelorosso, F., et al. (2017) · Science · doi:10.1126/science.aai8132 · Cited by 560 · see citing works
Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris
Caruso, S., & Poon, I. K. H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01486 · Cited by 541 · see citing works
Self-citationRecognition of Endogenous Nucleic Acids by the Innate Immune System
Roers, A., Hiller, B., & Hornung, V. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.002 · Cited by 541 · see citing works
Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity
Efimova, I., Catanzaro, E., der Meeren, L. V., Turubanova, V. D., Hammad, H., Mishchenko, T. A., Vedunova, M. V., Fimognari, C., Bachert, C., Coppieters, F., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001369 · Cited by 537 · see citing works
Immune suppressive mechanisms in the tumor microenvironment
Munn, D. H., & Bronte, V. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.10.009 · Cited by 519 · see citing works
Extracellular membrane vesicles in the three domains of life and beyond
Gill, S., Catchpole, R. J., & Forterre, P. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy042 · Cited by 501 · see citing works
Metabolism of tissue macrophages in homeostasis and pathology
Wculek, S. K., Dunphy, G., Heras-Murillo, I., Mastrangelo, A., & Sancho, D. (2022) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00791-9 · Cited by 501 · see citing works
Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N. S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.004 · Cited by 485 · see citing works
Merchant, M. L., Rood, I. M., Deegens, J. K., & Klein, J. B. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.148 · Cited by 498 · see citing works
Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication
Battistelli, M., & Falcieri, E. (2020) · Biology · doi:10.3390/biology9010021 · Cited by 479 · see citing works
Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses
Garg, A. D., & Agostinis, P. (2017) · Immunological Reviews · doi:10.1111/imr.12574 · Cited by 448 · see citing works
Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses
Elliott, M. R., Koster, K. M., & Murphy, P. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601520 · Cited by 440 · see citing works
Adipose tissue macrophages: going off track during obesity
Boutens, L., & Stienstra, R. (2016) · Diabetologia · doi:10.1007/s00125-016-3904-9 · Cited by 430 · see citing works
Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death
Kambara, H., Liu, F., Zhang, X., Liu, P., Bajrami, B., Teng, Y., Zhao, L., Zhou, S., Yu, H., Zhou, W., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.067 · Cited by 418 · see citing works
Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease
Prame Kumar, K., Nicholls, A. J., & Wong, C. H. Y. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2753-2 · Cited by 417 · see citing works
Sugimoto, M. A., Vago, J. P., Teixeira, M. M., & Sousa, L. P. (2016) · Journal of Immunology Research · doi:10.1155/2016/8239258 · Cited by 410 · see citing works
Cell death in the gut epithelium and implications for chronic inflammation
Patankar, J. V., & Becker, C. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0326-4 · Cited by 421 · see citing works
Apoptosis, Pyroptosis, and Necroptosis—Oh My! The Many Ways a Cell Can Die
Ketelut-Carneiro, N., & Fitzgerald, K. A. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167378 · Cited by 416 · see citing works
Fucikova, J. P., Špíšek, R., Kroemer, G., & Galluzzi, L. (2020) · Cell Research · doi:10.1038/s41422-020-0383-9 · Cited by 408 · see citing works
An, Y., Zhang, H., Wang, C., Jiao, F., Xu, H., Wang, X., Luan, W., Ma, F., Ni, L., Tang, X., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802805rr · Cited by 409 · see citing works
Innate sensing of oxidation-specific epitopes in health and disease
Binder, C. J., Papac-Milicevic, N., & Witztum, J. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.63 · Cited by 403 · see citing works
Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology
Morioka, S., Maueröder, C., & Ravichandran, K. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.018 · Cited by 391 · see citing works
Self-citationAtkin‐Smith, G. K., Tixeira, R., Paone, S., Mathivanan, S., Collins, C., Liem, M. K., Goodall, K. J., Ravichandran, K. S., Hulett, M. D., & Poon, I. K. H. (2015) · Nature Communications · doi:10.1038/ncomms8439 · Cited by 401 · see citing works
Self-citationApoptotic cell-derived exosomes: messages from dying cells
Kakarla, R., Hur, J., Kim, Y. J., Kim, J., & Chwae, Y. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0362-8 · Cited by 353 · see citing works
Sendler, M., van den Brandt, C., Glaubitz, J., Wilden, A., Golchert, J., Weiß, F. U., Homuth, G., Chama, L. L. D. F., Mishra, N., Mahajan, U. M., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.09.040 · Cited by 352 · see citing works
Liu, D., Kou, X., Chen, C., Liu, S., Liu, Y., Yu, W., Yu, T., Yang, R., Wang, R., Zhou, Y., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0070-2 · Cited by 336 · see citing works
He, X., Li, Y., Deng, B., Lin, A., Zhang, G., Ma, M., Wang, Y., Yang, Y., & Kang, X. (2022) · Cell Proliferation · doi:10.1111/cpr.13275 · Cited by 329 · see citing works
The Dynamics of Apoptotic Cell Clearance
Elliott, M. R., & Ravichandran, K. S. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.06.029 · Cited by 314 · see citing works
Self-citationStem Cell Extracellular Vesicles: Extended Messages of Regeneration
Riazifar, M., Pone, E. J., Lötvall, J. O., & Zhao, W. (2016) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-061616-030146 · Cited by 326 · see citing works
The clearance of dying cells: table for two
Green, D. R., Oguin, T. H., & Martinez, J. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.172 · Cited by 314 · see citing works
Bella, M. A. D. (2022) · Biology · doi:10.3390/biology11060804 · Cited by 316 · see citing works
Macrophages: Their Emerging Roles in Bone
Sinder, B. P., Pettit, A. R., & McCauley, L. K. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2735 · Cited by 301 · see citing works
Phagocytosis of Apoptotic Cells in Resolution of Inflammation
Kourtzelis, I., Hajishengallis, G., & Chavakis, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00553 · Cited by 301 · see citing works
Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis
Yurdagul, A., Doran, A. C., Cai, B., Fredman, G., & Tabas, I. A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00086 · Cited by 300 · see citing works
The role of neutrophils in inflammation resolution
Jones, H. R., Robb, C. T., Perretti, M., & Rossi, A. G. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.03.007 · Cited by 298 · see citing works
Self-citationAmara, A., & Mercer, J. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3469 · Cited by 294 · see citing works
Flores, A. M., Hosseini-Nassab, N., Jarr, K.-U., Ye, J., Zhu, X., Wirka, R. C., Koh, A. L., Tsantilas, P., Wang, Y., Nanda, V., et al. (2020) · Nature Nanotechnology · doi:10.1038/s41565-019-0619-3 · Cited by 289 · see citing works
The immune response to secondary necrotic cells
Sachet, M., Liang, Y. Y., & Oehler, R. (2017) · Apoptosis · doi:10.1007/s10495-017-1413-z · Cited by 282 · see citing works
Tumor-Associated Macrophages in Osteosarcoma: From Mechanisms to Therapy
Cersosimo, F., Lonardi, S., Bernardini, G., Telfer, B., Mandelli, G. E., Santucci, A., Vermi, W., & Giurisato, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155207 · Cited by 280 · see citing works
Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy
Krampera, M., & Blanc, K. L. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.09.006 · Cited by 265 · see citing works
Key mechanisms governing resolution of lung inflammation
Robb, C. T., Regan, K., Dorward, D. A., & Rossi, A. G. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0560-6 · Cited by 263 · see citing works
Self-citationTranscriptome of Extracellular Vesicles: State-of-the-Art
Turchinovich, A. A., Drapkina, O. M., & Tonevitsky, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00202 · Cited by 254 · see citing works
Morrissey, M. A., Kern, N., & Vale, R. D. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.008 · Cited by 252 · see citing works
Potey, P. M., Rossi, A. G., Lucas, C. D., & Dorward, D. A. (2018) · The Journal of Pathology · doi:10.1002/path.5221 · Cited by 248 · see citing works
Self-citationFerrington, D. A., Sinha, D., & Kaarniranta, K. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.09.002 · Cited by 241 · see citing works
The role of Kupffer cells in hepatic diseases
Li, P., He, K., Li, J., Liu, Z., & Gong, J. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.02.018 · Cited by 232 · see citing works
Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance
Luo, B., Gan, W., Liu, Z., Shen, Z., Wang, J., Shi, R., Liu, Y., Liu, Y., Jiang, M., Zhang, Z., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.002 · Cited by 229 · see citing works
Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs
Cummings, R. J., Barbet, G., Bongers, G., Hartmann, B. M., Gettler, K., Muniz, L., Furtado, G. C., Cho, J., Lira, S. A., & Blander, J. M. (2016) · Nature · doi:10.1038/nature20138 · Cited by 228 · see citing works
Sansbury, B. E., & Spite, M. R. (2016) · Circulation Research · doi:10.1161/circresaha.116.307308 · Cited by 226 · see citing works
Dendritic cells in the regulation of immunity and inflammation
Qian, C., & Cao, X. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.12.002 · Cited by 227 · see citing works
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53
Yoon, K. W., Byun, S., Kwon, E., Hwang, S.-Y., Chu, K., Hiraki, M., Jo, S., Weins, A., Hakroush, S., Cebulla, A., et al. (2015) · Science · doi:10.1126/science.1261669 · Cited by 225 · see citing works
Atherosclerosis – A matter of unresolved inflammation
Viola, J. R., & Soehnlein, O. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.03.013 · Cited by 227 · see citing works
Pietkiewicz, S., Schmidt, J. H., & Lavrik, I. N. (2015) · Journal of Immunological Methods · doi:10.1016/j.jim.2015.04.025 · Cited by 223 · see citing works
Disassembly of the Dying: Mechanisms and Functions
Atkin‐Smith, G. K., & Poon, I. K. H. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.08.011 · Cited by 214 · see citing works
Self-citationSavitskaya, M. A., & Онищенко, Г. Е. (2015) · Biochemistry (Moscow) · doi:10.1134/s0006297915110012 · Cited by 214 · see citing works
The Unfolded Protein Response in Immunogenic Cell Death and Cancer Immunotherapy
Rufo, N., Garg, A. D., & Agostinis, P. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.07.002 · Cited by 211 · see citing works
Li, C., Yang, Z., Cheng, J., Guo, J., Zhang, Q., Zhang, X., Ren, J., Wang, F., Huang, J., Hu, H., et al. (2019) · Advanced Science · doi:10.1002/advs.201900610 · Cited by 209 · see citing works
Blame the signaling: Role of cAMP for the resolution of inflammation
Tavares, L. P., Negreiros-Lima, G. L., Lima, K. M., Silva, P., Pinho, V., Teixeira, M. M., & Sousa, L. P. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105030 · Cited by 205 · see citing works
Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites
Braig, D., Nero, T. L., Koch, H.-G., Kaiser, B., Wang, X., Thiele, J. R., Morton, C. J., Zeller, J., Kiefer, J., Potempa, L. A., et al. (2017) · Nature Communications · doi:10.1038/ncomms14188 · Cited by 206 · see citing works
Phagocytosis of Necrotic Debris at Sites of Injury and Inflammation
Westman, J., Grinstein, S., & Marques, P. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03030 · Cited by 206 · see citing works
Shinde, R. S., Hezaveh, K., Halaby, M. J., Kloetgen, A., Chakravarthy, A., Medina, T. D. S., Deol, R., Manion, K., Baglaenko, Y., Eldh, M., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0107-1 · Cited by 200 · see citing works
Deep insight into cytokine storm: from pathogenesis to treatment
Nie, J., Zhou, L., Tian, W., Liu, X., Yang, L., Yang, X., Zhang, Y., Wei, S., Wang, D. W., & Wei, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02178-y · Cited by 224 · see citing works
Dieudé, M., Bell, C., Turgeon, J., Beillevaire, D., Pomerleau, L., Yang, B., Hamelin, K., Qi, S., Pallet, N., Béland, C., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac9816 · Cited by 201 · see citing works
Apoptotic Bodies: Mechanism of Formation, Isolation and Functional Relevance
Santavanond, J. P., Rutter, S. F., Atkin‐Smith, G. K., & Poon, I. K. H. (2021) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-67171-6_4 · Cited by 201 · see citing works
Self-citationImmunogenic Cell Death and Immunotherapy of Multiple Myeloma
del Valle, A. S., Anel, A., Naval, J., & Marzo, I. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00050 · Cited by 196 · see citing works
Cell death, clearance and immunity in the skeletal muscle
Sciorati, C., Rigamonti, E., Manfredi, A. A., & Rovere, P. Q. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2015.171 · Cited by 194 · see citing works
Tur, J., Pereira‐Lopes, S., Vico, T., Marín, E., Muñoz, J. P., Hernández‐Álvarez, M. I., Cardona, P.-J., Antonio Zorzano, A., Lloberas, J., & Celada, A. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108079 · Cited by 192 · see citing works
Role of the immunosuppressive microenvironment in immunotherapy
Tormoen, G. W., Crittenden, M. R., & Gough, M. J. (2018) · Advances in Radiation Oncology · doi:10.1016/j.adro.2018.08.018 · Cited by 194 · see citing works
Yu, L., Zhu, G., Zhang, Z., Yu, Y., Zeng, L., Xu, Z., Weng, J., Xia, J., Li, J., & Pathak, J. L. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01969-1 · Cited by 196 · see citing works
Abiega, O., Beccari, S., Díaz‐Aparicio, I., Nadjar, A., Layé, S., Leyrolle, Q., Gómez‐Nicola, D., Domercq, M., Pérez‐Samartín, A., Sánchez-Zafra, V., et al. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002466 · Cited by 181 · see citing works
Engulfment signals and the phagocytic machinery for apoptotic cell clearance
Park, S., & Kim, I. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.52 · Cited by 189 · see citing works
Brock, C. K., Wallin, S. T., Ruiz, O. E., Samms, K. M., Mandal, A., Sumner, E. A., & Eisenhoffer, G. T. (2019) · Nature Communications · doi:10.1038/s41467-019-09010-6 · Cited by 185 · see citing works
Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications
Najafi, M., Motevaseli, E., Shirazi, A., Geraily, G., Rezaeyan, A., Norouzi, F., Rezapoor, S., & Abdollahi, H. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1440092 · Cited by 182 · see citing works
Liu, J., Qiu, X., Lv, Y., Zheng, C., Dong, Y., Dou, G., Zhu, B., Liu, A., Wang, W., Zhou, J., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02014-w · Cited by 182 · see citing works
Roles of neutrophil granule proteins in orchestrating inflammation and immunity
Othman, A., Sekheri, M., & Filep, J. G. (2021) · FEBS Journal · doi:10.1111/febs.15803 · Cited by 184 · see citing works
Apoptosis in Cancer Biology and Therapy
Moyer, A. F., Tanaka, K., & Cheng, E. H. Y. (2025) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-051222-115023 · Cited by 202 · see citing works
Immune Priming of the Tumor Microenvironment by Radiation
Jiang, W., Chan, C. K. F., Weissman, I. L., Kim, B. Y. S., & Hahn, S. M. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.09.007 · Cited by 179 · see citing works
Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets
Gutiérrez-Martínez, E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00363 · Cited by 177 · see citing works
- Authors
- Poon, I. K. H., Lucas, C. D., Rossi, A. G., & Ravichandran, K. S.
- Affiliations
- La Trobe University (AU)
- Centre for Inflammation Research (GB)
- University of Virginia (US)
- Corresponding author
- Rossi, Adriano G.
- Ravichandran, Kodi S.
- Venue
- Nature Reviews Immunology
- Published
- 2014-01-31
- Volume
- 14
- Issue
- 3
- Pages
- 166-180
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4040260
- OpenAlex
- W2150334056
- Cited by
- 1,223
- References
- 197
- Citations by year
- 2026: 69 · 2025: 87 · 2024: 100 · 2023: 97 · 2022: 112 · 2021: 120 · 2020: 115 · 2019: 97 · 2018: 106 · 2017: 106 · 2016: 101 · 2015: 87 · 2014: 23 · 2013: 2
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (WT094415)
- Medical Research Council (MR/K013386/1)
- National Institute of Mental Health (R01MH096484, MH096484)
- National Institute of General Medical Sciences (GM-64709, R01GM107848, R01GM064709, GM107848)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD074981, R01HD074981)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- efferocytosis, phagocytes, apoptotic cell recognition, tissue homeostasis, immune tolerance, inflammation, autoimmunity, immunogenic cell death, antitumor immunity
- MeSH terms
- Animals, Humans, Immune Tolerance, Inflammation, Lupus Erythematosus, Systemic, Macrophages, Neoplasms, Phagocytes, Phagocytosis, Autoimmunity, Apoptosis, Atherosclerosis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review